JP7620984B2 - ８，９－ジヒドロカンナビジオール化合物の使用 - Google Patents

８，９－ジヒドロカンナビジオール化合物の使用 Download PDF

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JP7620984B2
JP7620984B2 JP2021553059A JP2021553059A JP7620984B2 JP 7620984 B2 JP7620984 B2 JP 7620984B2 JP 2021553059 A JP2021553059 A JP 2021553059A JP 2021553059 A JP2021553059 A JP 2021553059A JP 7620984 B2 JP7620984 B2 JP 7620984B2
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alkyl
alkenyl
alkynyl
acid
h2cbd
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JP2022525038A (ja
JP2022525038A5 (https=
Inventor
マスカル マーク
シェブチェンコ ニコライ
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
JP2021553059A 2019-03-08 2020-03-09 ８，９－ジヒドロカンナビジオール化合物の使用 Active JP7620984B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962815735P 2019-03-08 2019-03-08
US62/815,735 2019-03-08
PCT/US2020/021670 WO2020185661A1 (en) 2019-03-08 2020-03-09 Use of 8,9-dihydrocannabidiol compounds

Publications (3)

Publication Number Publication Date
JP2022525038A JP2022525038A (ja) 2022-05-11
JP2022525038A5 JP2022525038A5 (https=) 2023-03-16
JP7620984B2 true JP7620984B2 (ja) 2025-01-24

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JP2021553059A Active JP7620984B2 (ja) 2019-03-08 2020-03-09 ８，９－ジヒドロカンナビジオール化合物の使用

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US (1) US20250152520A2 (https=)
EP (1) EP3935037A4 (https=)
JP (1) JP7620984B2 (https=)
CN (1) CN113874344B (https=)
AU (1) AU2020236953A1 (https=)
BR (1) BR112021017661A2 (https=)
CA (1) CA3132841A1 (https=)
WO (1) WO2020185661A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021150885A1 (en) * 2020-01-24 2021-07-29 Perkinelmer Health Sciences, Inc. Cannabinoid derivatives
CN114507153B (zh) * 2020-11-17 2025-06-24 中国科学院上海药物研究所 一类间苯二酚化合物及其制备方法以及在神经系统疾病中的应用
CN113372196B (zh) * 2021-07-02 2022-09-30 江南大学 8,9-二氢大麻二酚及其合成方法与应用
WO2024006896A1 (en) * 2022-06-29 2024-01-04 The Regents Of The University Of California Uses of hydrogenated cannabidiol (h4cbd) and advanced metabolic syndrome
AU2024359022A1 (en) * 2023-10-10 2026-04-09 Jazz Pharmaceuticals Research Uk Limited Cannabinoid compounds and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523708A (ja) 2010-03-30 2013-06-17 ジーダブリュー・ファーマ・リミテッド てんかんの治療におけるフィトカンナビノイドカンナビジバリン（ｃｂｄｖ）の使用
JP2017524672A (ja) 2014-06-17 2017-08-31 ジーダブリュー・ファーマ・リミテッドＧｗ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ てんかんの治療におけるカンナビノイドの使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018777A (en) * 1975-11-14 1977-04-19 Abbott Laboratories 2-Substituted-5-alkyl resorcinols
CN108024973A (zh) * 2015-07-16 2018-05-11 耶路撒冷希伯来大学伊森姆研究发展有限公司 氟化的cbd化合物、其组合物以及用途
CN108785298A (zh) * 2017-04-27 2018-11-13 汉义生物科技（北京）有限公司 一种用于治疗癫痫的药物组合物、其制备方法及用途
CN109106699A (zh) * 2017-06-23 2019-01-01 汉义生物科技（北京）有限公司 一种用于治疗癫痫的药物组合物、其制备方法及用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523708A (ja) 2010-03-30 2013-06-17 ジーダブリュー・ファーマ・リミテッド てんかんの治療におけるフィトカンナビノイドカンナビジバリン（ｃｂｄｖ）の使用
JP2017524672A (ja) 2014-06-17 2017-08-31 ジーダブリュー・ファーマ・リミテッドＧｗ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ てんかんの治療におけるカンナビノイドの使用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B. Cardillo et al.，ALKYLATION OF RESORCINOLS WITH MONOTERPENOID ALLYLIC ALCOHOLS IN AQUEOUS ACID: SYNTHESIS OF NEW CANNABINOID DERIVATIVES，Tetrahedron Letters，Elsevier，1972年，no.10，945-948
Megan N. Huizenga et al.，Preclinical safety and efficacyof cannabidivarin for early life seizures，Neuropharmacology，Elsevier，2019年01月10日，vol.148，189-198
Noriyuki Usami et al.，Formation of Carbon Monoxide during Mouse Hepatic Microsomal Oxidative Metabolism of Cannabidiol; Identification and Determination，Biological and Pharmaceutical Bulletin，日本，日本薬学会，1995年，vol.18, no.4，529-535
Orrin Devinsky et al.，Trial of Cannabidiol fpr Drug-Resistant Seizures in Dravet Syndrome，The New England Journal of Medicine，Massachusetts Medical Society，2017年05月25日，vol.376, no.21，2011-2020
Shimon Ben-Shabat et al.，New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity，Journal of Medicinal Chemistry，American Chemical Society，2006年，vol.49, no.3，1113-1117

Also Published As

Publication number Publication date
US20250152520A2 (en) 2025-05-15
EP3935037A4 (en) 2023-03-22
BR112021017661A2 (pt) 2021-11-16
CN113874344B (zh) 2025-05-27
JP2022525038A (ja) 2022-05-11
US20220183998A1 (en) 2022-06-16
AU2020236953A1 (en) 2021-09-30
WO2020185661A1 (en) 2020-09-17
EP3935037A1 (en) 2022-01-12
CA3132841A1 (en) 2020-09-17
CN113874344A (zh) 2021-12-31

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