JP7594329B2 - 抗菌活性を有する新規メラノイジンの製造方法とその応用 - Google Patents

抗菌活性を有する新規メラノイジンの製造方法とその応用 Download PDF

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JP7594329B2
JP7594329B2 JP2023554537A JP2023554537A JP7594329B2 JP 7594329 B2 JP7594329 B2 JP 7594329B2 JP 2023554537 A JP2023554537 A JP 2023554537A JP 2023554537 A JP2023554537 A JP 2023554537A JP 7594329 B2 JP7594329 B2 JP 7594329B2
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Prior art keywords
melanoidin
xylose
group
antibacterial activity
phenylalanine
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JPWO2023068112A5 (https=
JPWO2023068112A1 (https=
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成樹 小関
直樹 北岡
英幸 松浦
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Hokkaido University NUC
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Hokkaido University NUC
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/762—Organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/771—Organic compounds containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Agronomy & Crop Science (AREA)
  • Food Science & Technology (AREA)
  • Dentistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2023554537A 2021-10-19 2022-10-11 抗菌活性を有する新規メラノイジンの製造方法とその応用 Active JP7594329B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021170957 2021-10-19
JP2021170957 2021-10-19
PCT/JP2022/037898 WO2023068112A1 (ja) 2021-10-19 2022-10-11 抗菌活性を有する新規メラノイジンの製造方法とその応用

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JPWO2023068112A5 JPWO2023068112A5 (https=) 2024-06-28
JP7594329B2 true JP7594329B2 (ja) 2024-12-04

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117530992A (zh) * 2023-11-28 2024-02-09 中国农业科学院深圳农业基因组研究所(岭南现代农业科学与技术广东省实验室深圳分中心) 植物基组合物及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
JPS5618170B1 (https=) * 1970-09-25 1981-04-27
JP2009171890A (ja) * 2008-01-24 2009-08-06 Tsukishima Foods Industry Co Ltd 抗酸化パン及び菓子

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ALAVEZ-ROSAS, D. et al.，Synthesis of 1,3- and 1,2,3-functionalized pyrroles via Ir(I)-catalyzed vinylation of allyl alcohols，Chemistry of Heterocyclic Compounds，2017年，Vol.53, No.5，pp.526-531，DOI 10.1007/s10593-017-2087-8
ALBRECHT, Uwe et al.，Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents，Bioorganic & Medicinal Chemistry，2005年，Vol.13，pp.1531-1536，DOI:10.1016/j.bmc.2004.12.031
ANDEREGG, P. and NEUKOM, H.，Formation of dehydration products from pentoses and purine ribosides by heating in buffer at pH2-7，Lebensmitt.-Wiss. u. Technol.，1974年，Vol.7, No.4，pp.239-241
BADRAN, Al-Shimaa et al.，Reactivity of some 3-substituted-6,8-dimethylchromones toward some nucleophilic reagents，J Heterocyclic Chem.，2020年，Vol.57，pp.2570-2585，DOI: 10.1002/jhet.3975
CHANDRASEKHAR, M. V. et al.，Studies on chromones，Acta Ciencia Indica，1985年，Vol.16c, No.4，pp.247-251
HOEGBERG, Thomas et al.，Structure-Activity Relationships among DNA-Gyrase Inhibitors. Synthesis and Antimicrobial Evaluation，Acta Chemica Scandinavica B，1984年，Vol.38，pp.359-366
LINDGREN, G. et al.，A high performance preparative procedure for the isolation of degradation products from D-xylose，Journal of liquid chromatography，1980年，Vol.3, No.11，pp.1737-1742
中島智恭，アミノカルボニル反応物の抗菌性，食品の包装，1988年，Vol.20, No.1，pp.33-40
大下克典，醤油の機能性について，日本醸造協会誌，1990年，Vol.85, No.11，pp.762-770，DOI：10.6013/jbrewsocjapan1988.85.762
小関成樹，糖とアミノ酸で食品有害細菌を抑制：食品加工中に生じるメイラード反応物質の抗菌活性，飯島藤十郎記念食品科学振興財団年報，Vol.37，2022年08月，pp.120-128
文部科学省，日本食品標準成分表２０１５年版（七訂）アミノ酸成分表編，１７調味料及び香辛料類，2015年12月，p.1，インターネット＜URL：https://www.mext.go.jp/component/a_menu/science/detail/__icsFiles/afieldfile/2015/12/24/1365347_2-0217-1.pdf＞
清水利貞ほか，調味料中における数種病原および食中毒菌の生存期間について，日本食品工業学会誌，1962年，Vol.9, No.5，pp.198-200，DOI:10.3136/nskkk1962.9.198
続・糖類の検出法，INTERNET ARCHIVE Wayback Machine [online]，2016年07月13日，pp.1-2，[検索日：2022年12月13日]，インターネット：<URL:https://web.archive.org/web/20160713031205/http://www.an.shimadzu.co.jp/hplc/support/lib/lctalk/51/51intro.htm>

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WO2023068112A1 (ja) 2023-04-27
WO2023067825A1 (ja) 2023-04-27
JPWO2023068112A1 (https=) 2023-04-27

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