JP7581264B2 - 細胞および組織への薬剤の送達のための新規ペプチド、組成物および方法 - Google Patents

細胞および組織への薬剤の送達のための新規ペプチド、組成物および方法 Download PDF

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JP7581264B2
JP7581264B2 JP2021578241A JP2021578241A JP7581264B2 JP 7581264 B2 JP7581264 B2 JP 7581264B2 JP 2021578241 A JP2021578241 A JP 2021578241A JP 2021578241 A JP2021578241 A JP 2021578241A JP 7581264 B2 JP7581264 B2 JP 7581264B2
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ラジェンドラ クマール-シン
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Tufts University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/49Platelet-derived growth factor [PDGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2021578241A 2019-07-02 2020-07-02 細胞および組織への薬剤の送達のための新規ペプチド、組成物および方法 Active JP7581264B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962869831P 2019-07-02 2019-07-02
US62/869,831 2019-07-02
PCT/US2020/040720 WO2021034418A2 (en) 2019-07-02 2020-07-02 Novel peptide, compositions and method for delivery of agents into cells and tissues

Publications (4)

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JP2022538903A JP2022538903A (ja) 2022-09-06
JP2022538903A5 JP2022538903A5 (https=) 2023-07-11
JPWO2021034418A5 JPWO2021034418A5 (https=) 2023-07-11
JP7581264B2 true JP7581264B2 (ja) 2024-11-12

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JP2021578241A Active JP7581264B2 (ja) 2019-07-02 2020-07-02 細胞および組織への薬剤の送達のための新規ペプチド、組成物および方法

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US (2) US11713337B2 (https=)
EP (1) EP3994151A4 (https=)
JP (1) JP7581264B2 (https=)
KR (1) KR20220039725A (https=)
CN (1) CN114555625B (https=)
AU (1) AU2020332268B2 (https=)
CA (1) CA3144963A1 (https=)
IL (1) IL289516A (https=)
WO (1) WO2021034418A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3100276A1 (en) 2018-06-06 2019-12-12 Massachusetts Institute Of Technology Circular rna for translation in eukaryotic cells
WO2026005189A1 (ko) * 2024-06-27 2026-01-02 이엔셀 주식회사 안구 세포 또는 조직을 표적하는 펩타이드 및 이를 포함하는 바이러스 캡시드 단백질 및 바이러스 벡터

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002518050A (ja) 1998-06-19 2002-06-25 メディジーン・アクチェンゲゼルシャフト Aavの構造タンパク質、その製造及び用途
JP2007531691A (ja) 2003-05-19 2007-11-08 デルマゲン アクティエボラーグ ヘパリン結合活性を有する新規な抗微生物ペプチド
JP2012530787A (ja) 2009-06-22 2012-12-06 バーナム インスティテュート フォー メディカル リサーチ C末端エレメントを有するペプチドおよびタンパク質を使用する方法および組成物
US20130158103A1 (en) 2011-11-23 2013-06-20 The Curators Of The University Of Missouri Method of Tissue-Selective Targeted Gene Transfer
WO2016143828A1 (ja) 2015-03-12 2016-09-15 三洋化成工業株式会社 タンパク質組成物の製造方法及びタンパク質組成物
US20170349628A1 (en) 2014-10-02 2017-12-07 Temple University-Of The Commonwealth System Of Higher Education Synthesis of Cell Penetrating Peptides for Drug Delivery and Stem Cell Applications

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211657A (en) * 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
JP3635462B2 (ja) * 2000-05-31 2005-04-06 国立医薬品食品衛生研究所長 アデノウイルスベクター
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
AU2008295509A1 (en) * 2007-08-29 2009-03-12 Tufts University Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits
EP2187907A2 (en) * 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Use of tyr-w-mif-1 and urocortin 2 as therapeutic agents
EP3076792B1 (en) * 2013-12-04 2020-11-11 Newleaf Symbiotics, Inc. Compositions and methods for improving lettuce production
US9738687B2 (en) * 2015-04-10 2017-08-22 Feldan Bio Inc. Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002518050A (ja) 1998-06-19 2002-06-25 メディジーン・アクチェンゲゼルシャフト Aavの構造タンパク質、その製造及び用途
JP2007531691A (ja) 2003-05-19 2007-11-08 デルマゲン アクティエボラーグ ヘパリン結合活性を有する新規な抗微生物ペプチド
JP2012530787A (ja) 2009-06-22 2012-12-06 バーナム インスティテュート フォー メディカル リサーチ C末端エレメントを有するペプチドおよびタンパク質を使用する方法および組成物
US20130158103A1 (en) 2011-11-23 2013-06-20 The Curators Of The University Of Missouri Method of Tissue-Selective Targeted Gene Transfer
US20170349628A1 (en) 2014-10-02 2017-12-07 Temple University-Of The Commonwealth System Of Higher Education Synthesis of Cell Penetrating Peptides for Drug Delivery and Stem Cell Applications
WO2016143828A1 (ja) 2015-03-12 2016-09-15 三洋化成工業株式会社 タンパク質組成物の製造方法及びタンパク質組成物

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Publication number Publication date
US20230340024A1 (en) 2023-10-26
AU2020332268A1 (en) 2022-02-24
KR20220039725A (ko) 2022-03-29
CN114555625A (zh) 2022-05-27
WO2021034418A2 (en) 2021-02-25
CN114555625B (zh) 2025-02-25
JP2022538903A (ja) 2022-09-06
WO2021034418A3 (en) 2021-04-01
AU2020332268B2 (en) 2025-04-24
US11713337B2 (en) 2023-08-01
EP3994151A2 (en) 2022-05-11
IL289516A (en) 2022-03-01
EP3994151A4 (en) 2023-07-19
US20220204562A1 (en) 2022-06-30
CA3144963A1 (en) 2021-02-25

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