JP7581225B2 - Ｃｔｌａ－４遮断剤とｐｄ－１遮断剤とを含む抗癌併用療法 - Google Patents

Ｃｔｌａ－４遮断剤とｐｄ－１遮断剤とを含む抗癌併用療法 Download PDF

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JP7581225B2
JP7581225B2 JP2021553837A JP2021553837A JP7581225B2 JP 7581225 B2 JP7581225 B2 JP 7581225B2 JP 2021553837 A JP2021553837 A JP 2021553837A JP 2021553837 A JP2021553837 A JP 2021553837A JP 7581225 B2 JP7581225 B2 JP 7581225B2
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ctla
cancer
amino acid
antibody
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JP2022525071A5 (https=
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ラフェイス，ドレイク
プノネン，ユハ
ボーマン，エドワード
バウシュ，デイビッド
チャッカリアン，アリッサ
グライン，ジェフリー
モーゼ，スミタ
サワント，アナンディ
アンナマライ，ラクシュマナン
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メルク・シャープ・アンド・ドーム・エルエルシー
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021553837A 2019-03-13 2020-03-10 Ｃｔｌａ－４遮断剤とｐｄ－１遮断剤とを含む抗癌併用療法 Active JP7581225B2 (ja)

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US201962817749P 2019-03-13 2019-03-13
US62/817,749 2019-03-13
PCT/US2020/021783 WO2020185722A2 (en) 2019-03-13 2020-03-10 Anti-cancer combination therapies comprising ctla-4 and pd-1 blocking agents

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JP2022525071A JP2022525071A (ja) 2022-05-11
JP2022525071A5 JP2022525071A5 (https=) 2023-03-24
JP7581225B2 true JP7581225B2 (ja) 2024-11-12

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US (2) US12358986B2 (https=)
EP (1) EP3937979A4 (https=)
JP (1) JP7581225B2 (https=)
KR (1) KR20210141539A (https=)
CN (1) CN113631189A (https=)
AU (1) AU2020234785A1 (https=)
BR (1) BR112021017892A8 (https=)
CA (1) CA3132198A1 (https=)
MA (1) MA55316A (https=)
MX (1) MX2021010997A (https=)
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EP4324854A4 (en) * 2021-04-14 2025-04-23 Akeso Pharmaceuticals, Inc. USE OF ANTIBODIES IN ANTITUMOR TREATMENT
CN117203235A (zh) * 2021-04-21 2023-12-08 和铂医药(上海)有限责任公司 结合ctla-4的抗体及其用途
KR20230110141A (ko) 2022-01-14 2023-07-21 영남대학교 산학협력단 PD-L1 단백질에 특이적으로 결합하는 Fab 단편 및 이의 용도
EP4522654A1 (en) * 2022-05-12 2025-03-19 BioNTech SE Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
CN121816195A (zh) * 2023-08-21 2026-04-07 艾吉纳斯公司 使用ctla-4抑制剂和pd-1抑制剂的组合治疗结直肠癌的方法
WO2025211692A1 (ko) * 2024-04-02 2025-10-09 (주)에트노바테라퓨틱스 암 예방 또는 치료를 위한 병용 투여용 약학 조성물 세트
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JP2017515859A (ja) 2014-05-15 2017-06-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｐｄ−１抗体と他の抗癌剤の組み合わせを使用する肺癌の処置

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EP3937979A2 (en) 2022-01-19
KR20210141539A (ko) 2021-11-23
JP2022525071A (ja) 2022-05-11
US20250289890A1 (en) 2025-09-18
MA55316A (fr) 2022-01-19
WO2020185722A3 (en) 2020-11-12
US20220411507A1 (en) 2022-12-29
EP3937979A4 (en) 2023-03-08
BR112021017892A8 (pt) 2023-01-31
CA3132198A1 (en) 2020-09-17
BR112021017892A2 (https=) 2021-12-07
MX2021010997A (es) 2021-10-01
WO2020185722A2 (en) 2020-09-17
AU2020234785A1 (en) 2021-08-19
US12358986B2 (en) 2025-07-15
CN113631189A (zh) 2021-11-09

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