JP7565214B2 - 溶解に耐える組織接着性キトサン材料 - Google Patents
溶解に耐える組織接着性キトサン材料 Download PDFInfo
- Publication number
- JP7565214B2 JP7565214B2 JP2020535507A JP2020535507A JP7565214B2 JP 7565214 B2 JP7565214 B2 JP 7565214B2 JP 2020535507 A JP2020535507 A JP 2020535507A JP 2020535507 A JP2020535507 A JP 2020535507A JP 7565214 B2 JP7565214 B2 JP 7565214B2
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- dressing
- chitosan material
- catechol
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920001661 Chitosan Polymers 0.000 title claims description 515
- 239000000463 material Substances 0.000 title claims description 259
- 238000004090 dissolution Methods 0.000 title claims description 56
- 239000003106 tissue adhesive Substances 0.000 title description 13
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims description 156
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 112
- 208000027418 Wounds and injury Diseases 0.000 claims description 79
- 208000014674 injury Diseases 0.000 claims description 75
- 229910001868 water Inorganic materials 0.000 claims description 73
- 210000001519 tissue Anatomy 0.000 claims description 67
- 230000002496 gastric effect Effects 0.000 claims description 63
- 230000006378 damage Effects 0.000 claims description 62
- 230000001070 adhesive effect Effects 0.000 claims description 54
- 239000000853 adhesive Substances 0.000 claims description 53
- 239000008280 blood Substances 0.000 claims description 46
- 210000004369 blood Anatomy 0.000 claims description 46
- 210000002700 urine Anatomy 0.000 claims description 35
- 239000012530 fluid Substances 0.000 claims description 32
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
- 210000004877 mucosa Anatomy 0.000 claims description 30
- 239000007787 solid Substances 0.000 claims description 27
- CFFZDZCDUFSOFZ-UHFFFAOYSA-N 3,4-Dihydroxy-phenylacetic acid Chemical compound OC(=O)CC1=CC=C(O)C(O)=C1 CFFZDZCDUFSOFZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000835 fiber Substances 0.000 claims description 20
- 239000013060 biological fluid Substances 0.000 claims description 19
- 208000035475 disorder Diseases 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 14
- 230000008733 trauma Effects 0.000 claims description 14
- 230000002209 hydrophobic effect Effects 0.000 claims description 12
- 238000005336 cracking Methods 0.000 claims description 10
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 8
- 229960002442 glucosamine Drugs 0.000 claims description 8
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 7
- WOAHJDHKFWSLKE-UHFFFAOYSA-N 1,2-benzoquinone Chemical compound O=C1C=CC=CC1=O WOAHJDHKFWSLKE-UHFFFAOYSA-N 0.000 claims description 6
- XZHWAGZSWOAEPI-UHFFFAOYSA-N C(C=CC1=CC(O)=C(O)C=C1)(=O)O.OC=1C=C(C=CC(=O)O)C=CC1O Chemical compound C(C=CC1=CC(O)=C(O)C=C1)(=O)O.OC=1C=C(C=CC(=O)O)C=CC1O XZHWAGZSWOAEPI-UHFFFAOYSA-N 0.000 claims description 6
- 238000013467 fragmentation Methods 0.000 claims description 6
- 238000006062 fragmentation reaction Methods 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 239000002250 absorbent Substances 0.000 claims description 5
- 230000002745 absorbent Effects 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 230000003628 erosive effect Effects 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- FCRAWHRICODQTR-UHFFFAOYSA-N 3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound OC(=O)CCC1=CC=C(O)C(O)=C1.OC(=O)CCC1=CC=C(O)C(O)=C1 FCRAWHRICODQTR-UHFFFAOYSA-N 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000011243 crosslinked material Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 204
- 238000000576 coating method Methods 0.000 description 126
- 208000032843 Hemorrhage Diseases 0.000 description 118
- 208000034158 bleeding Diseases 0.000 description 117
- 230000000740 bleeding effect Effects 0.000 description 117
- 239000011248 coating agent Substances 0.000 description 99
- 238000000034 method Methods 0.000 description 76
- 238000012360 testing method Methods 0.000 description 75
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 56
- 238000007906 compression Methods 0.000 description 55
- 230000006835 compression Effects 0.000 description 50
- 239000000203 mixture Substances 0.000 description 43
- BPRJTLAULHNDLP-UHFFFAOYSA-N Chloropanaxydiol Chemical compound CCCCCCCC1OC1CC#CC#CC(O)C(O)CCl BPRJTLAULHNDLP-UHFFFAOYSA-N 0.000 description 40
- DZAUWHJDUNRCTF-UHFFFAOYSA-N 3-(3,4-dihydroxyphenyl)propanoic acid Chemical group OC(=O)CCC1=CC=C(O)C(O)=C1 DZAUWHJDUNRCTF-UHFFFAOYSA-N 0.000 description 36
- 239000010410 layer Substances 0.000 description 32
- 229920001477 hydrophilic polymer Polymers 0.000 description 31
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 29
- 230000002439 hemostatic effect Effects 0.000 description 29
- 238000006243 chemical reaction Methods 0.000 description 27
- 238000005191 phase separation Methods 0.000 description 27
- 239000008367 deionised water Substances 0.000 description 26
- 229910021641 deionized water Inorganic materials 0.000 description 26
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 24
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 24
- 241001465754 Metazoa Species 0.000 description 23
- 238000000502 dialysis Methods 0.000 description 22
- 238000001035 drying Methods 0.000 description 21
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 description 20
- 238000013459 approach Methods 0.000 description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 19
- 230000023597 hemostasis Effects 0.000 description 19
- 210000002784 stomach Anatomy 0.000 description 19
- 206010052428 Wound Diseases 0.000 description 18
- 230000008014 freezing Effects 0.000 description 18
- 238000007710 freezing Methods 0.000 description 18
- 238000002835 absorbance Methods 0.000 description 17
- 239000007864 aqueous solution Substances 0.000 description 17
- 238000009472 formulation Methods 0.000 description 17
- 230000015572 biosynthetic process Effects 0.000 description 16
- 210000002307 prostate Anatomy 0.000 description 16
- 238000011471 prostatectomy Methods 0.000 description 16
- 239000011541 reaction mixture Substances 0.000 description 16
- 239000000523 sample Substances 0.000 description 16
- 238000006467 substitution reaction Methods 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 15
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 14
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 14
- 238000002271 resection Methods 0.000 description 14
- 238000001356 surgical procedure Methods 0.000 description 14
- 230000001154 acute effect Effects 0.000 description 13
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 13
- 229920000642 polymer Polymers 0.000 description 13
- 238000002560 therapeutic procedure Methods 0.000 description 13
- 238000006731 degradation reaction Methods 0.000 description 12
- 238000004108 freeze drying Methods 0.000 description 12
- 238000000338 in vitro Methods 0.000 description 12
- 238000001727 in vivo Methods 0.000 description 12
- 239000011159 matrix material Substances 0.000 description 12
- 230000003014 reinforcing effect Effects 0.000 description 12
- 210000003708 urethra Anatomy 0.000 description 12
- 238000001574 biopsy Methods 0.000 description 11
- 230000015556 catabolic process Effects 0.000 description 11
- 210000001035 gastrointestinal tract Anatomy 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 239000011148 porous material Substances 0.000 description 11
- 239000000376 reactant Substances 0.000 description 11
- 229940127219 anticoagulant drug Drugs 0.000 description 10
- 238000001816 cooling Methods 0.000 description 10
- 238000003786 synthesis reaction Methods 0.000 description 10
- 229920001651 Cyanoacrylate Polymers 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 9
- -1 gastric juice Substances 0.000 description 9
- 230000003647 oxidation Effects 0.000 description 9
- 238000007254 oxidation reaction Methods 0.000 description 9
- 238000007789 sealing Methods 0.000 description 9
- 208000007536 Thrombosis Diseases 0.000 description 8
- 208000031737 Tissue Adhesions Diseases 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 210000001156 gastric mucosa Anatomy 0.000 description 8
- 238000009434 installation Methods 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 8
- 241000283690 Bos taurus Species 0.000 description 7
- 229960000583 acetic acid Drugs 0.000 description 7
- 239000010408 film Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000004806 packaging method and process Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000009467 reduction Effects 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 238000000859 sublimation Methods 0.000 description 7
- 230000008022 sublimation Effects 0.000 description 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
- 206010053567 Coagulopathies Diseases 0.000 description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 6
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 6
- 241000282887 Suidae Species 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 238000007726 management method Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 5
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 5
- 230000032798 delamination Effects 0.000 description 5
- 230000001079 digestive effect Effects 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 239000003292 glue Substances 0.000 description 5
- 230000035876 healing Effects 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000009736 wetting Methods 0.000 description 5
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 208000000624 Esophageal and Gastric Varices Diseases 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 4
- 230000006181 N-acylation Effects 0.000 description 4
- 102000057297 Pepsin A Human genes 0.000 description 4
- 108090000284 Pepsin A Proteins 0.000 description 4
- 239000004809 Teflon Substances 0.000 description 4
- 229920006362 Teflon® Polymers 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 206010056091 Varices oesophageal Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000001464 adherent effect Effects 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000000975 bioactive effect Effects 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 206010061592 cardiac fibrillation Diseases 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000015271 coagulation Effects 0.000 description 4
- 238000005345 coagulation Methods 0.000 description 4
- 230000006196 deacetylation Effects 0.000 description 4
- 238000003381 deacetylation reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000002600 fibrillogenic effect Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 235000011167 hydrochloric acid Nutrition 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 238000002324 minimally invasive surgery Methods 0.000 description 4
- 239000005022 packaging material Substances 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 229940111202 pepsin Drugs 0.000 description 4
- 230000002035 prolonged effect Effects 0.000 description 4
- 230000000541 pulsatile effect Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000005096 rolling process Methods 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 210000004876 tela submucosa Anatomy 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 206010060964 Arterial haemorrhage Diseases 0.000 description 3
- 206010003162 Arterial injury Diseases 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 3
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 3
- 206010050953 Lower gastrointestinal haemorrhage Diseases 0.000 description 3
- 229920002274 Nalgene Polymers 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 208000009443 Vascular Malformations Diseases 0.000 description 3
- 206010065441 Venous haemorrhage Diseases 0.000 description 3
- 210000003815 abdominal wall Anatomy 0.000 description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 238000000137 annealing Methods 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 208000015294 blood coagulation disease Diseases 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000035602 clotting Effects 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 238000012505 colouration Methods 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000001066 destructive effect Effects 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 238000007922 dissolution test Methods 0.000 description 3
- 238000009297 electrocoagulation Methods 0.000 description 3
- 238000001839 endoscopy Methods 0.000 description 3
- 208000024170 esophageal varices Diseases 0.000 description 3
- 201000010120 esophageal varix Diseases 0.000 description 3
- 229960002897 heparin Drugs 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000002262 irrigation Effects 0.000 description 3
- 238000003973 irrigation Methods 0.000 description 3
- 229960002725 isoflurane Drugs 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 229920001684 low density polyethylene Polymers 0.000 description 3
- 239000004702 low-density polyethylene Substances 0.000 description 3
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000007493 shaping process Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000002344 surface layer Substances 0.000 description 3
- 238000011477 surgical intervention Methods 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical group OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 2
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 2
- 206010017788 Gastric haemorrhage Diseases 0.000 description 2
- 206010061459 Gastrointestinal ulcer Diseases 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 208000028373 Neck injury Diseases 0.000 description 2
- 206010028851 Necrosis Diseases 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 206010051077 Post procedural haemorrhage Diseases 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 206010071229 Procedural haemorrhage Diseases 0.000 description 2
- 239000002262 Schiff base Substances 0.000 description 2
- 150000004753 Schiff bases Chemical class 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 208000024248 Vascular System injury Diseases 0.000 description 2
- 208000012339 Vascular injury Diseases 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 231100000899 acute systemic toxicity Toxicity 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 230000003872 anastomosis Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000010100 anticoagulation Effects 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000005068 bladder tissue Anatomy 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000009799 cystectomy Methods 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000010102 embolization Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 210000004300 gastroepiploic artery Anatomy 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 230000009477 glass transition Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 208000031169 hemorrhagic disease Diseases 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000004310 lactic acid Chemical class 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 238000002350 laparotomy Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000010907 mechanical stirring Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012978 minimally invasive surgical procedure Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920009441 perflouroethylene propylene Polymers 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000013310 pig model Methods 0.000 description 2
- 238000011020 pilot scale process Methods 0.000 description 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229920001992 poloxamer 407 Polymers 0.000 description 2
- 229940044476 poloxamer 407 Drugs 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000012798 spherical particle Substances 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 230000003393 splenic effect Effects 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 2
- 201000011531 vascular cancer Diseases 0.000 description 2
- 206010055031 vascular neoplasm Diseases 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Chemical group OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- ZUYKJZQOPXDNOK-UHFFFAOYSA-N 2-(ethylamino)-2-thiophen-2-ylcyclohexan-1-one;hydrochloride Chemical compound Cl.C=1C=CSC=1C1(NCC)CCCCC1=O ZUYKJZQOPXDNOK-UHFFFAOYSA-N 0.000 description 1
- 238000010146 3D printing Methods 0.000 description 1
- NJERAXSSDSHLGE-UHFFFAOYSA-N 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride Chemical compound Cl.N=1CC(=O)N(C)C(N(N=C2C)C)=C2C=1C1=CC=CC=C1F NJERAXSSDSHLGE-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 description 1
- 208000031872 Body Remains Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 208000004652 Cardiovascular Abnormalities Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 206010051012 Gastric varices Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 238000006845 Michael addition reaction Methods 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical class CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010053159 Organ failure Diseases 0.000 description 1
- 206010033372 Pain and discomfort Diseases 0.000 description 1
- 229920001363 Polidocanol Polymers 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010036960 Prostatic haemorrhage Diseases 0.000 description 1
- 239000008156 Ringer's lactate solution Substances 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000004830 Super Glue Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000012931 Urologic disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical class O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 1
- 229940052299 calcium chloride dihydrate Drugs 0.000 description 1
- ZEWYCNBZMPELPF-UHFFFAOYSA-J calcium;potassium;sodium;2-hydroxypropanoic acid;sodium;tetrachloride Chemical compound [Na].[Na+].[Cl-].[Cl-].[Cl-].[Cl-].[K+].[Ca+2].CC(O)C(O)=O ZEWYCNBZMPELPF-UHFFFAOYSA-J 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- SRZNHPXWXCNNDU-RHBCBLIFSA-N cefotetan Chemical compound N([C@]1(OC)C(N2C(=C(CSC=3N(N=NN=3)C)CS[C@@H]21)C(O)=O)=O)C(=O)C1SC(=C(C(N)=O)C(O)=O)S1 SRZNHPXWXCNNDU-RHBCBLIFSA-N 0.000 description 1
- 229960005495 cefotetan Drugs 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- PBAYDYUZOSNJGU-UHFFFAOYSA-N chelidonic acid Natural products OC(=O)C1=CC(=O)C=C(C(O)=O)O1 PBAYDYUZOSNJGU-UHFFFAOYSA-N 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Chemical group OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000009502 compressed coating Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229940072645 coumadin Drugs 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 238000001861 endoscopic biopsy Methods 0.000 description 1
- 238000011846 endoscopic investigation Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 150000002302 glucosamines Chemical class 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 229940015042 glycopyrrolate Drugs 0.000 description 1
- 238000000892 gravimetry Methods 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 208000011316 hemodynamic instability Diseases 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 239000004620 low density foam Substances 0.000 description 1
- 229940050906 magnesium chloride hexahydrate Drugs 0.000 description 1
- DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 208000011309 nasal bleeding Diseases 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229940020573 plavix Drugs 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229960002226 polidocanol Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000003229 sclerosing agent Substances 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 description 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
- 229940039790 sodium oxalate Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000007655 standard test method Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940052907 telazol Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- 229940075469 tissue adhesives Drugs 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 206010051250 ureteritis Diseases 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01012—Non-adhesive bandages or dressings characterised by the material being made of natural material, e.g. cellulose-, protein-, collagen-based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762612013P | 2017-12-29 | 2017-12-29 | |
| US62/612,013 | 2017-12-29 | ||
| US201862631290P | 2018-02-15 | 2018-02-15 | |
| US62/631,290 | 2018-02-15 | ||
| PCT/US2018/068064 WO2019133936A1 (en) | 2017-12-29 | 2018-12-28 | Tissue adherent chitosan material that resists dissolution |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021508751A JP2021508751A (ja) | 2021-03-11 |
| JP2021508751A5 JP2021508751A5 (https=) | 2023-08-09 |
| JP7565214B2 true JP7565214B2 (ja) | 2024-10-10 |
Family
ID=65139278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020535507A Active JP7565214B2 (ja) | 2017-12-29 | 2018-12-28 | 溶解に耐える組織接着性キトサン材料 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3731791B1 (https=) |
| JP (1) | JP7565214B2 (https=) |
| CN (1) | CN111787892B (https=) |
| WO (1) | WO2019133936A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021025617A1 (en) * | 2019-08-02 | 2021-02-11 | Nanyang Technological University | Self-curing redox donor/acceptor adhesive composition |
| CN112121238A (zh) * | 2020-03-18 | 2020-12-25 | 武汉大学 | 一种多功能复合抗粘连材料及其制备方法 |
| WO2022020518A1 (en) * | 2020-07-21 | 2022-01-27 | Molecular Surface Technologies, Llc | Antimicrobial surfaces via multicomponent chitosan conjugates |
| CN113398310B (zh) * | 2021-06-28 | 2022-05-17 | 福建师范大学 | 壳聚糖儿茶酚止血纱布及其制备方法 |
| US12453348B2 (en) | 2021-07-20 | 2025-10-28 | Quatssant, Llc | Antimicrobial with modified-chitosan functionalization via dopamine linkage |
| CN118846202A (zh) * | 2024-06-28 | 2024-10-29 | 广东适配生物科技有限公司 | 一种用于感染创面止血和治疗的伤口敷料及其制备方法 |
| CN119454623B (zh) * | 2025-01-16 | 2025-04-11 | 宁波科瑞特动物药业有限公司 | 一种烯丙孕素缓释药剂及其制备方法 |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005503197A (ja) | 2001-06-14 | 2005-02-03 | プロビデンス ヘルス システム−オレゴン | 創傷被覆材、および重篤で生命にかかわる出血を制御する方法 |
| JP2007516051A (ja) | 2003-12-23 | 2007-06-21 | ヘムコン, インコーポレイテッド | キトサンのような親水性ポリマースポンジ構造体から形成される、組織被覆用のアセンブリ、システムおよび方法 |
| JP2008525112A (ja) | 2004-12-23 | 2008-07-17 | ヘムコン, インコーポレイテッド | キトサンのような親水性ポリマー構造から形成された抗微生物バリア、系及び方法 |
| CN101289477A (zh) | 2007-04-20 | 2008-10-22 | 中国科学院大连化学物理研究所 | 一种n-苯丙烯酰基壳寡糖及其制备 |
| JP2009502749A (ja) | 2005-07-13 | 2009-01-29 | ヘムコン, インコーポレイテッド | キトサンから形成された粒子状止血剤を使用し、ポリ−4−ヒドロキシブチレートのポリマーメッシュ材料を含む、止血組成物、アセンブリ、システムおよび方法 |
| JP2009513239A (ja) | 2005-10-28 | 2009-04-02 | ヘムコン, インコーポレイテッド | 親水性のポリマー歯科用スポンジ |
| WO2013180458A1 (ko) | 2012-05-29 | 2013-12-05 | 한국교통대학교 산학협력단 | 약물전달용 가교물 하이드로 젤 및 그 하이드로 젤의 제조방법 |
| JP2016138166A (ja) | 2015-01-26 | 2016-08-04 | 国立大学法人鳥取大学 | 表面に微細構造を有するキトサンフィルムの製造方法およびそれを用いて製造されたキトサンフィルム |
| WO2016159734A1 (ko) | 2015-04-03 | 2016-10-06 | 주식회사 이노테라피 | 카테콜 기 및 산화된 카테콜 기가 도입되어 가교된 키토산으로 코팅된 무출혈 주사바늘 |
| CN111632026A (zh) | 2020-04-20 | 2020-09-08 | 杭州鹿扬科技有限公司 | 一种自组装短肽水凝胶及其用途 |
| CN113209363A (zh) | 2021-04-30 | 2021-08-06 | 暨南大学 | 一种粘附止血可注射壳聚糖凝胶及其制备方法与应用 |
| CN115895440A (zh) | 2022-10-28 | 2023-04-04 | 上谷新材料(苏州)有限公司 | 一种易返工橡胶表面处理剂及其制备方法 |
| JP2023516335A (ja) | 2020-03-02 | 2023-04-19 | イノセラピー インコーポレイテッド | 止血被覆材及びその製造方法 |
| CN116540072A (zh) | 2023-04-28 | 2023-08-04 | 江苏富联通讯技术股份有限公司 | 一种5g通讯模组检测装置及其使用方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
| US8269058B2 (en) | 2002-06-14 | 2012-09-18 | Hemcon Medical Technologies, Inc. | Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| US20050137512A1 (en) | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
| EP1799228B1 (en) * | 2004-09-14 | 2010-04-14 | Ajinomoto Omnichem S.A. | Topical compositions containing phosphorylated polyphenols |
| US9204957B2 (en) | 2005-03-17 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Systems and methods for hemorrhage control and or tissue repair |
| JP2009538192A (ja) * | 2006-05-23 | 2009-11-05 | プロビデンス ヘルス システム−オレゴン ディー/ビー/エー プロビデンス セント ビンセント メディカル センター | 体の内腔または体の中空器官内に包帯構造を導入および適用するシステムおよび方法 |
| GB0622970D0 (en) * | 2006-11-17 | 2006-12-27 | Medtrade Products Ltd | Medical device |
| US20090214712A1 (en) * | 2008-02-21 | 2009-08-27 | The Coca Cola Company | Milk-Based Beverage and Method for Preventing Off-Flavors in a Milk-Based Beverage |
| US9061087B2 (en) * | 2008-03-04 | 2015-06-23 | Hemostasis, Llc | Method of making a hemostatic sponge wound dressing comprising subjecting the sponge to water vapor |
| AU2009241687A1 (en) | 2008-05-02 | 2009-11-05 | Providence Health System-Oregon D/B/A Providence St. Vincent Medical Center | Wound dressing devices and methods |
| EP2340002B1 (en) | 2008-10-06 | 2015-03-25 | Providence Health System - Oregon | Foam medical devices and methods |
| EA024569B1 (ru) * | 2010-08-27 | 2016-09-30 | Олиго Медик Инк. | Высокобиосовместимые композиции хитозана/солей глюкозамина с двусторонним термогелеобразованием |
| EP2778179A4 (en) * | 2011-09-27 | 2015-03-04 | Postech Acad Ind Found | CHITOSAN AND / OR CHITIN COMPOSITE WITH IMPROVED PHYSICAL PROPERTIES AND USE THEREOF |
| CN104245004A (zh) * | 2012-02-09 | 2014-12-24 | 高丽大学校产学协力团 | 具有用于改进骨融合的抗菌功能的抗生素、释放骨形成促进材料的植入物或支架及其制造方法 |
| US9485953B2 (en) * | 2012-07-19 | 2016-11-08 | R.J. Reynolds Tobacco Company | Method for treating tobacco plants with enzymes |
| GB2514592A (en) * | 2013-05-30 | 2014-12-03 | Medtrade Products Ltd | Degradable haemostat composition |
| KR101791241B1 (ko) * | 2014-06-17 | 2017-10-30 | 한국과학기술원 | 카테콜 아민 기반의 다기능성 필름 및 이의 제조 방법 |
| CN104013990A (zh) * | 2014-06-18 | 2014-09-03 | 海南建科药业有限公司 | 具有儿茶酚基改性的壳聚糖及其制成的生物医学材料 |
| EP3463277A4 (en) * | 2016-06-06 | 2020-01-01 | GDD Therapeutics, LLC | FORMULATIONS FOR SUBSTITUTED 3-PYRROLIDINES, COMPOSITIONS THEREFOR AND USES THEREOF |
| CN107118357B (zh) * | 2017-05-15 | 2019-07-02 | 哈尔滨工业大学 | 一种儿茶酚壳聚糖自愈合水凝胶材料及其制备方法 |
| CN107375196B (zh) * | 2017-07-26 | 2020-02-07 | 暨南大学 | 一种含儿茶酚基天然多糖复合水凝胶载体及其制备方法 |
| KR20220161796A (ko) * | 2021-05-31 | 2022-12-07 | 한국과학기술원 | 하이드로젤 기반의 마찰전기 나노 발전기 및 이를 포함하는 웨어러블 센서 |
-
2018
- 2018-12-28 CN CN201880090516.6A patent/CN111787892B/zh active Active
- 2018-12-28 WO PCT/US2018/068064 patent/WO2019133936A1/en not_active Ceased
- 2018-12-28 EP EP18837137.1A patent/EP3731791B1/en active Active
- 2018-12-28 JP JP2020535507A patent/JP7565214B2/ja active Active
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005503197A (ja) | 2001-06-14 | 2005-02-03 | プロビデンス ヘルス システム−オレゴン | 創傷被覆材、および重篤で生命にかかわる出血を制御する方法 |
| JP2007516051A (ja) | 2003-12-23 | 2007-06-21 | ヘムコン, インコーポレイテッド | キトサンのような親水性ポリマースポンジ構造体から形成される、組織被覆用のアセンブリ、システムおよび方法 |
| JP2008525112A (ja) | 2004-12-23 | 2008-07-17 | ヘムコン, インコーポレイテッド | キトサンのような親水性ポリマー構造から形成された抗微生物バリア、系及び方法 |
| JP2009502749A (ja) | 2005-07-13 | 2009-01-29 | ヘムコン, インコーポレイテッド | キトサンから形成された粒子状止血剤を使用し、ポリ−4−ヒドロキシブチレートのポリマーメッシュ材料を含む、止血組成物、アセンブリ、システムおよび方法 |
| JP2009513239A (ja) | 2005-10-28 | 2009-04-02 | ヘムコン, インコーポレイテッド | 親水性のポリマー歯科用スポンジ |
| CN101289477A (zh) | 2007-04-20 | 2008-10-22 | 中国科学院大连化学物理研究所 | 一种n-苯丙烯酰基壳寡糖及其制备 |
| WO2013180458A1 (ko) | 2012-05-29 | 2013-12-05 | 한국교통대학교 산학협력단 | 약물전달용 가교물 하이드로 젤 및 그 하이드로 젤의 제조방법 |
| JP2016138166A (ja) | 2015-01-26 | 2016-08-04 | 国立大学法人鳥取大学 | 表面に微細構造を有するキトサンフィルムの製造方法およびそれを用いて製造されたキトサンフィルム |
| WO2016159734A1 (ko) | 2015-04-03 | 2016-10-06 | 주식회사 이노테라피 | 카테콜 기 및 산화된 카테콜 기가 도입되어 가교된 키토산으로 코팅된 무출혈 주사바늘 |
| JP2023516335A (ja) | 2020-03-02 | 2023-04-19 | イノセラピー インコーポレイテッド | 止血被覆材及びその製造方法 |
| CN111632026A (zh) | 2020-04-20 | 2020-09-08 | 杭州鹿扬科技有限公司 | 一种自组装短肽水凝胶及其用途 |
| CN113209363A (zh) | 2021-04-30 | 2021-08-06 | 暨南大学 | 一种粘附止血可注射壳聚糖凝胶及其制备方法与应用 |
| CN115895440A (zh) | 2022-10-28 | 2023-04-04 | 上谷新材料(苏州)有限公司 | 一种易返工橡胶表面处理剂及其制备方法 |
| CN116540072A (zh) | 2023-04-28 | 2023-08-04 | 江苏富联通讯技术股份有限公司 | 一种5g通讯模组检测装置及其使用方法 |
Non-Patent Citations (4)
| Title |
|---|
| Ji Hyun Ryu et al.,Bio-Inspired, Water-Soluble to Insoluble Self-Conversion for Flexible, Biocompatible, Transparent, Catecholamine Polysaccharide Thin Films,Advanced Functional Materials,2014年10月06日,Volume 24, Issue 48,pp. 7709-7716 |
| Jinke Xu et al.,Mollusk Glue Inspired Mucoadhesives for Biomedical Applications,Langmuir,2012年09月05日,Volume 28, Issue 39,pp. 14010-14017 |
| Kyuri Kim et al.,Chitosan-catechol: A polymer with long-lasting mucoadhesive properties,Biomaterials,Volume 52,pp. 161-170 |
| Zhiwen Zeng et al.,Rapid in situ cross-linking of hydrogel adhesives based on thiol-grafted bio-inspired catechol-conjugated chitosan,Journal of Biomaterials Applications,2017年11月07日,Volume 32, Issue 5,pp. 612-621 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3731791A1 (en) | 2020-11-04 |
| US20210060203A1 (en) | 2021-03-04 |
| WO2019133936A1 (en) | 2019-07-04 |
| CN111787892A (zh) | 2020-10-16 |
| CN111787892B (zh) | 2025-02-18 |
| JP2021508751A (ja) | 2021-03-11 |
| EP3731791B1 (en) | 2024-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7565214B2 (ja) | 溶解に耐える組織接着性キトサン材料 | |
| US20230355224A1 (en) | Delivery systems for control of gastrointestinal bleeding | |
| US20210052766A1 (en) | Chitosan dressing for control of gastrointestinal bleeding | |
| US12156791B2 (en) | Chitosan dressing for control of bleeding in transurethral prostatectomy | |
| US12508171B2 (en) | Delivery systems for control of bleeding in transurethral prostatectomy | |
| JP5931339B2 (ja) | 生物相容性の止血、癒着防止、癒合促進、外科密封可能な変性澱粉材料 | |
| US10195312B2 (en) | Modified starch material of biocompatible hemostasis | |
| JP6552115B2 (ja) | 消化管病変を治療するための接着性医療製品及び方法 | |
| JP2011509932A5 (https=) | ||
| JPH1066723A (ja) | 酸化多糖類から形成される生体吸収性医療具 | |
| CN101472620A (zh) | 用于影响污染物、机体流体或其它实体移动和/或影响其它生理状况的组合物和方法 | |
| JP2021508751A5 (https=) | ||
| US20240269339A1 (en) | Dissolution resistant tissue adherent dressing application and its delivery | |
| US12616771B2 (en) | Tissue adherent chitosan material that resists dissolution | |
| CN111936175A (zh) | 防粘连用组合物 | |
| JP2025541136A (ja) | 溶解に耐える流動性キトサン生体接着性止血組成物 | |
| KR20250008770A (ko) | 물 활성화 하이드로겔 기반 의료용 패치, 유연한 기재 및 이러한 패치의 제조 및 사용 방법 | |
| BRPI0706906A2 (pt) | folha multilamelar aderente a tecido, método de manufatura de uma folha, dispositivo apropriado para o implante no corpo humano ou animal e método de união de uma superfìcie do tecido a um outro tecido, ou de vedação de uma superfìcie do tecido |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211221 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20211221 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230201 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20230428 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20230630 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20230801 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20231102 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20240110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240502 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20240814 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20240903 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20240930 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7565214 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |