JP7546552B2 - ポリマーベースの高分子プロドラッグ - Google Patents
ポリマーベースの高分子プロドラッグ Download PDFInfo
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- JP7546552B2 JP7546552B2 JP2021514531A JP2021514531A JP7546552B2 JP 7546552 B2 JP7546552 B2 JP 7546552B2 JP 2021514531 A JP2021514531 A JP 2021514531A JP 2021514531 A JP2021514531 A JP 2021514531A JP 7546552 B2 JP7546552 B2 JP 7546552B2
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- 239000000243 solution Substances 0.000 description 1
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- GOQZIPJCBUYLIR-UHFFFAOYSA-N tert-butyl n-[n-[(2-methylpropan-2-yl)oxycarbonyl]-n'-(trifluoromethylsulfonyl)carbamimidoyl]carbamate Chemical compound CC(C)(C)OC(=O)NC(=NS(=O)(=O)C(F)(F)F)NC(=O)OC(C)(C)C GOQZIPJCBUYLIR-UHFFFAOYSA-N 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
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| US62/732,199 | 2018-09-17 | ||
| PCT/US2019/051457 WO2020061007A1 (en) | 2018-09-17 | 2019-09-17 | Polymer-based macromolecular prodrugs |
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| JP2022501341A JP2022501341A (ja) | 2022-01-06 |
| JPWO2020061007A5 JPWO2020061007A5 (enExample) | 2022-09-26 |
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| CN112996533B (zh) * | 2018-09-17 | 2025-01-10 | 费城儿童医院 | 基于聚合物的大分子前药 |
| CN115443947B (zh) * | 2022-10-12 | 2023-11-21 | 江苏省人民医院（南京医科大学第一附属医院） | 高血压动物模型的制备方法 |
| WO2025101904A1 (en) * | 2023-11-08 | 2025-05-15 | The Children's Hospital Of Philadelphia | Norepinephrine transporter-targeted prodrugs for cancer therapy |
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| JP2016531895A (ja) | 2013-10-04 | 2016-10-13 | プロリンクス エルエルシー | Ｓｎ−３８の徐放性コンジュゲート |
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-
2019
- 2019-09-17 CN CN201980060783.3A patent/CN112996533B/zh active Active
- 2019-09-17 WO PCT/US2019/051457 patent/WO2020061007A1/en not_active Ceased
- 2019-09-17 MX MX2021003116A patent/MX2021003116A/es unknown
- 2019-09-17 EP EP19863240.8A patent/EP3852793B1/en active Active
- 2019-09-17 JP JP2021514531A patent/JP7546552B2/ja active Active
- 2019-09-17 AU AU2019344783A patent/AU2019344783B2/en active Active
- 2019-09-17 CA CA3112778A patent/CA3112778A1/en active Pending
- 2019-09-17 CN CN202510008384.XA patent/CN119950749A/zh active Pending
- 2019-09-17 KR KR1020217011264A patent/KR20210072002A/ko active Pending
- 2019-09-17 US US16/969,790 patent/US11253603B2/en active Active
- 2019-09-17 EA EA202190799A patent/EA202190799A1/ru unknown
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2023
- 2023-04-27 US US18/140,289 patent/US12311028B2/en active Active
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2025
- 2025-05-13 US US19/206,574 patent/US20250387496A1/en active Pending
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| WO1999052861A1 (de) | 1998-04-09 | 1999-10-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik |
| JP2002255821A (ja) | 2001-03-06 | 2002-09-11 | Yakult Honsha Co Ltd | 抗癌剤耐性癌に対する治療剤 |
| JP2012503602A (ja) | 2008-09-23 | 2012-02-09 | ネクター セラピューティックス | 対象において持続的治療薬濃度を実現するための組成物及び方法 |
| JP2012506380A (ja) | 2008-10-21 | 2012-03-15 | エンゾン ファーマシューティカルズ，インコーポレーテッド | ７−エチル−１０−ヒドロキシカンプトテシンのマルチアーム型ポリマーコンジュゲートによる神経芽腫の治療 |
| JP2013511539A (ja) | 2009-11-18 | 2013-04-04 | ネクター セラピューティックス | ポリマー−薬物コンジュゲートの酸性塩形態及びアルコキシル化方法 |
| JP2016531895A (ja) | 2013-10-04 | 2016-10-13 | プロリンクス エルエルシー | Ｓｎ−３８の徐放性コンジュゲート |
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| EA202190799A1 (ru) | 2021-06-22 |
| WO2020061007A1 (en) | 2020-03-26 |
| MX2021003116A (es) | 2021-05-14 |
| CA3112778A1 (en) | 2020-03-26 |
| KR20210072002A (ko) | 2021-06-16 |
| US11253603B2 (en) | 2022-02-22 |
| CN119950749A (zh) | 2025-05-09 |
| US20210000967A1 (en) | 2021-01-07 |
| US12311028B2 (en) | 2025-05-27 |
| US20250387496A1 (en) | 2025-12-25 |
| US20220160886A1 (en) | 2022-05-26 |
| JP2022501341A (ja) | 2022-01-06 |
| AU2019344783A1 (en) | 2021-04-08 |
| AU2019344783B2 (en) | 2025-10-23 |
| US11642414B2 (en) | 2023-05-09 |
| EP3852793A1 (en) | 2021-07-28 |
| NZ773863A (en) | 2024-10-25 |
| EP3852793B1 (en) | 2025-11-19 |
| CN112996533A (zh) | 2021-06-18 |
| CN112996533B (zh) | 2025-01-10 |
| US20230414766A1 (en) | 2023-12-28 |
| EP3852793A4 (en) | 2022-07-13 |
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