JP7542644B2 - チアミンの類似体及び誘導体と結合するアプタマー - Google Patents

チアミンの類似体及び誘導体と結合するアプタマー Download PDF

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JP7542644B2
JP7542644B2 JP2022557797A JP2022557797A JP7542644B2 JP 7542644 B2 JP7542644 B2 JP 7542644B2 JP 2022557797 A JP2022557797 A JP 2022557797A JP 2022557797 A JP2022557797 A JP 2022557797A JP 7542644 B2 JP7542644 B2 JP 7542644B2
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aryl
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aptamer
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cycloalkyl
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クオ シュエツイ
フォーブズ アレクサンドリア
ジー．リウ ケビン
キム チ－イン
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メイラグティーエックス ユーケー アイアイ リミティド
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  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022557797A 2020-03-24 2021-03-24 チアミンの類似体及び誘導体と結合するアプタマー Active JP7542644B2 (ja)

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Application Number Priority Date Filing Date Title
US202062994135P 2020-03-24 2020-03-24
US62/994,135 2020-03-24
PCT/IB2021/000163 WO2021191680A1 (en) 2020-03-24 2021-03-24 Aptamers that bind thiamine analogs and derivatives

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JP2023519266A JP2023519266A (ja) 2023-05-10
JP2023519266A5 JP2023519266A5 (https=) 2024-04-03
JP7542644B2 true JP7542644B2 (ja) 2024-08-30

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US (1) US12570988B2 (https=)
EP (1) EP4127176A1 (https=)
JP (1) JP7542644B2 (https=)
KR (1) KR102879552B1 (https=)
CN (1) CN115698292A (https=)
AU (1) AU2021243743B2 (https=)
BR (1) BR112022019284A2 (https=)
CA (1) CA3172864A1 (https=)
IL (1) IL296711B2 (https=)
MX (1) MX2022011940A (https=)
PH (1) PH12022552557A1 (https=)
WO (1) WO2021191680A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3239306A1 (en) * 2021-12-15 2023-06-22 Xuecui GUO Aptamers and small molecule ligands
CN117417301A (zh) * 2022-01-26 2024-01-19 上海日馨医药科技股份有限公司 含硫类化合物、其药物组合物及应用
EP4599064A1 (en) * 2022-10-07 2025-08-13 Okinawa Institute of Science and Technology School Corporation An rna aptamer that binds to asp7967 or an analogue thereof

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
EP2614150A1 (en) 2010-09-07 2013-07-17 Yeda Research and Development Co. Ltd. Thiamine pyrophosphate (tpp) riboswitch mutants producing vitamin b1 enriched food and feed crops
KR102699584B1 (ko) 2015-02-02 2024-08-28 메이라지티엑스 유케이 Ii 리미티드 대안적 스플라이싱의 압타머 매개 조절에 의한 유전자 발현 제어
ES2954929T3 (es) 2016-02-02 2023-11-27 Meiragtx Uk Ii Ltd Regulación de expresión génica mediante control mediado por aptámeros de ribozimas de autocorte
AU2017213835C1 (en) 2016-02-02 2024-04-18 MeiraGTx Gene Regulation Limited Regulation of gene expression through aptamer-modulated polyadenylation
ES3024480T3 (en) 2017-02-21 2025-06-04 Meiragtx Uk Ii Ltd Regulation of gene expression by aptamer-mediated accessibility of polyadenylation signals
SG11201908043UA (en) 2017-03-02 2019-09-27 Meiragtx Uk Ii Limited Regulation of gene expression by aptamer-modulated rnase p cleavage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EDWARDS, T. et al，Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition，Structure，2006年，Vol.14，pp.1459-1468

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US20230265441A1 (en) 2023-08-24
BR112022019284A2 (pt) 2023-02-14
MX2022011940A (es) 2023-01-05
PH12022552557A1 (en) 2024-04-22
JP2023519266A (ja) 2023-05-10
WO2021191680A1 (en) 2021-09-30
IL296711B2 (en) 2025-09-01
US12570988B2 (en) 2026-03-10
CN115698292A (zh) 2023-02-03
IL296711B1 (en) 2025-05-01
AU2021243743B2 (en) 2025-08-07
EP4127176A1 (en) 2023-02-08
IL296711A (en) 2022-11-01
KR102879552B1 (ko) 2025-11-10
KR20230019816A (ko) 2023-02-09
AU2021243743A1 (en) 2022-11-24
CA3172864A1 (en) 2021-09-30

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