JP7539374B2 - ボロン酸ポリマーおよび使用方法 - Google Patents

ボロン酸ポリマーおよび使用方法 Download PDF

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JP7539374B2
JP7539374B2 JP2021516652A JP2021516652A JP7539374B2 JP 7539374 B2 JP7539374 B2 JP 7539374B2 JP 2021516652 A JP2021516652 A JP 2021516652A JP 2021516652 A JP2021516652 A JP 2021516652A JP 7539374 B2 JP7539374 B2 JP 7539374B2
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polymer
pharmaceutical composition
cationic polymer
solution
polymers
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Japanese (ja)
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JP2022501483A (ja
JP2022501483A5 (enExample
Inventor
トーマス ヘンリー ジョゼフィアック，
アシシュ ニムガオンカー，
スティーブン シー． ポロモスカニク，
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グライセンド， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L43/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metal; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
    • C08F230/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing boron

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2021516652A 2018-09-20 2019-09-20 ボロン酸ポリマーおよび使用方法 Active JP7539374B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024073800A JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862734054P 2018-09-20 2018-09-20
US62/734,054 2018-09-20
PCT/US2019/052110 WO2020061430A1 (en) 2018-09-20 2019-09-20 Boronic acid polymers and methods of use

Related Child Applications (1)

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JP2024073800A Division JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

Publications (3)

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JP2022501483A JP2022501483A (ja) 2022-01-06
JP2022501483A5 JP2022501483A5 (enExample) 2024-05-15
JP7539374B2 true JP7539374B2 (ja) 2024-08-23

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JP2021516652A Active JP7539374B2 (ja) 2018-09-20 2019-09-20 ボロン酸ポリマーおよび使用方法
JP2024073800A Pending JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

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US (1) US20210403625A1 (enExample)
EP (1) EP3852768A4 (enExample)
JP (2) JP7539374B2 (enExample)
WO (1) WO2020061430A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020244556A1 (zh) * 2019-06-06 2020-12-10 上海交通大学 一种治疗或预防糖类物质相关疾病或病症的方法
EP4031553A4 (en) 2019-09-20 2023-11-01 Glyscend, Inc. POLYMERS WITH SUBSTITUTED PHENYLBORONIC ACID AND METHOD OF USE
CN116333197A (zh) * 2023-04-12 2023-06-27 厦门君德医药科技有限公司 胃肠道粘膜性聚合物、组合物及制备方法和应用
WO2026053928A1 (ja) * 2024-09-03 2026-03-12 株式会社シード 重合性ボロン酸化合物及び重合性カチオン性化合物を構成単位として含む高分子化合物及びその利用
CN120005104B (zh) * 2025-01-23 2025-10-31 武汉理工大学 一种pH响应型聚氨酯纳米材料、药物递送系统及制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134062A1 (en) 2002-11-19 2006-06-22 Huval Chad C Polymeric boronic acid derivatives as lipase inhibitors
WO2009066746A1 (ja) 2007-11-22 2009-05-28 The University Of Tokyo 組織癒着防止材および関節拘縮防止材
JP2016209372A (ja) 2015-05-11 2016-12-15 国立大学法人 東京医科歯科大学 インスリン送達用デバイス

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05310844A (ja) * 1992-05-08 1993-11-22 Nippon Oil & Fats Co Ltd フェニルボロン酸基含有重合体
JPH07304971A (ja) * 1994-05-09 1995-11-21 Nippon Oil & Fats Co Ltd 糖応答性高分子材料
JP3867400B2 (ja) * 1998-05-08 2007-01-10 日本油脂株式会社 ボロン酸基含有単量体およびその重合体
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
ATE450274T1 (de) * 2002-07-22 2009-12-15 Psimei Pharmaceuticals Plc Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen
CN105017481B (zh) * 2010-02-24 2018-10-02 瑞立普萨公司 用作胆汁酸螯合剂的交联聚乙烯胺、聚烯丙胺和乙烯亚胺
WO2013028548A2 (en) * 2011-08-19 2013-02-28 The Regents Of The University Of California Compositions and devices for the detection of biomarkers in the gastrointestinal tract and methods for making and using them
EP3331499A4 (en) * 2015-08-06 2019-04-10 The Johns Hopkins University COMPOSITION AND METHOD FOR THE TREATMENT OF METABOLISM DISEASES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134062A1 (en) 2002-11-19 2006-06-22 Huval Chad C Polymeric boronic acid derivatives as lipase inhibitors
WO2009066746A1 (ja) 2007-11-22 2009-05-28 The University Of Tokyo 組織癒着防止材および関節拘縮防止材
JP2016209372A (ja) 2015-05-11 2016-12-15 国立大学法人 東京医科歯科大学 インスリン送達用デバイス

Also Published As

Publication number Publication date
WO2020061430A1 (en) 2020-03-26
JP2022501483A (ja) 2022-01-06
US20210403625A1 (en) 2021-12-30
EP3852768A1 (en) 2021-07-28
EP3852768A4 (en) 2022-09-14
JP2024096280A (ja) 2024-07-12

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