JP7538040B2 - ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物 - Google Patents

ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物 Download PDF

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JP7538040B2
JP7538040B2 JP2020538573A JP2020538573A JP7538040B2 JP 7538040 B2 JP7538040 B2 JP 7538040B2 JP 2020538573 A JP2020538573 A JP 2020538573A JP 2020538573 A JP2020538573 A JP 2020538573A JP 7538040 B2 JP7538040 B2 JP 7538040B2
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pharma
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JP2021510695A (ja
JP2021510695A5 (https=
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アルバート ジーン ロビチャウド，
フランセスコ ジー． サリトゥロ，
マリア ヘスス ブランコ－ピヤド，
ダニエル ラ，
ボイド エル． ハリソン，
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Sage Therapeutics LLC
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Sage Therapeutics LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/006—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by sulfur as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2020538573A 2018-01-12 2019-01-11 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物 Active JP7538040B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023127398A JP7817214B2 (ja) 2018-01-12 2023-08-03 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物
JP2025061337A JP2025106370A (ja) 2018-01-12 2025-04-02 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862616768P 2018-01-12 2018-01-12
US201862617134P 2018-01-12 2018-01-12
US62/617,134 2018-01-12
US62/616,768 2018-01-12
US201862728514P 2018-09-07 2018-09-07
US62/728,514 2018-09-07
PCT/US2019/013315 WO2019140272A1 (en) 2018-01-12 2019-01-11 Aza-, oxa and thia-pregnan-20-one-3.alpha.-ol compounds for use in treating cns disorders

Related Child Applications (1)

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JP2023127398A Division JP7817214B2 (ja) 2018-01-12 2023-08-03 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物

Publications (3)

Publication Number Publication Date
JP2021510695A JP2021510695A (ja) 2021-04-30
JP2021510695A5 JP2021510695A5 (https=) 2022-01-18
JP7538040B2 true JP7538040B2 (ja) 2024-08-21

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JP2020538573A Active JP7538040B2 (ja) 2018-01-12 2019-01-11 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物
JP2023127398A Active JP7817214B2 (ja) 2018-01-12 2023-08-03 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物
JP2025061337A Pending JP2025106370A (ja) 2018-01-12 2025-04-02 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物

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JP2023127398A Active JP7817214B2 (ja) 2018-01-12 2023-08-03 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物
JP2025061337A Pending JP2025106370A (ja) 2018-01-12 2025-04-02 ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物

Country Status (6)

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US (3) US11718642B2 (https=)
EP (2) EP4706761A3 (https=)
JP (3) JP7538040B2 (https=)
MA (1) MA51568A (https=)
TW (1) TW201930269A (https=)
WO (1) WO2019140272A1 (https=)

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EP2806877B2 (en) 2012-01-23 2025-01-29 Sage Therapeutics, Inc. Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc
TW201930269A (zh) 2018-01-12 2019-08-01 美商賽吉醫療公司 用於治療cns病症之組合物及方法
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
KR20220112803A (ko) * 2019-12-05 2022-08-11 세이지 테라퓨틱스, 인크. 19-nor c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
CN111233815B (zh) * 2020-01-21 2022-10-14 上海应用技术大学 一种异阿根廷蚁素的制备方法
EP4125921A1 (en) 2020-03-25 2023-02-08 Sage Therapeutics, Inc. Use of agents for treatment of respiratory conditions
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs

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US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
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NZ298567A (en) * 1994-11-23 2000-01-28 Cocensys Inc Androstane and pregnane derivatives, pharmaceutical compositions and methods of treatment
ATE284895T1 (de) 1995-06-06 2005-01-15 Euro Celtique Sa Neuroaktive steroide der androstan- und pregnanreihe
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Also Published As

Publication number Publication date
US12421275B2 (en) 2025-09-23
TW201930269A (zh) 2019-08-01
JP2025106370A (ja) 2025-07-15
JP2021510695A (ja) 2021-04-30
US20240150393A1 (en) 2024-05-09
EP4706761A3 (en) 2026-05-06
US20200354399A1 (en) 2020-11-12
EP3737687A1 (en) 2020-11-18
US20260078143A1 (en) 2026-03-19
JP2023145726A (ja) 2023-10-11
EP4706761A2 (en) 2026-03-11
US11718642B2 (en) 2023-08-08
JP7817214B2 (ja) 2026-02-18
EP3737687B1 (en) 2025-10-22
MA51568A (fr) 2021-04-21
WO2019140272A1 (en) 2019-07-18

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