JP7489323B2 - Ｃｄ７３阻害剤 - Google Patents

Ｃｄ７３阻害剤 Download PDF

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Publication number
JP7489323B2
JP7489323B2 JP2020560361A JP2020560361A JP7489323B2 JP 7489323 B2 JP7489323 B2 JP 7489323B2 JP 2020560361 A JP2020560361 A JP 2020560361A JP 2020560361 A JP2020560361 A JP 2020560361A JP 7489323 B2 JP7489323 B2 JP 7489323B2
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alkyl
heterocycloalkyl
cycloalkyl
heteroaryl
aryl
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JP2021522280A (ja
JP2021522280A5 (enExample
Inventor
ドュ，シャオフイ
エクステロウィッツ，ジョン
ファンティン，ヴァレリア，アール．
サン，ダチン
イェ，チョウピン
ムーア，ジャレド
ザヴォロティンスカヤ，タチアナ
ブランク，ブライアン，アール．
リュウ，ヨサップ
ウー，ケジア
ズー，リュウシェン
ファム，ジョニー
カワイ，ヒロユキ
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オリック ファーマシューティカルズ，インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2020560361A 2018-04-30 2019-04-30 Ｃｄ７３阻害剤 Active JP7489323B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024078186A JP2024112864A (ja) 2018-04-30 2024-05-13 Ｃｄ７３阻害剤

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862664841P 2018-04-30 2018-04-30
US62/664,841 2018-04-30
US201862737647P 2018-09-27 2018-09-27
US62/737,647 2018-09-27
US201862757714P 2018-11-08 2018-11-08
US62/757,714 2018-11-08
US201862777697P 2018-12-10 2018-12-10
US62/777,697 2018-12-10
US201962810790P 2019-02-26 2019-02-26
US62/810,790 2019-02-26
PCT/US2019/030068 WO2019213174A1 (en) 2018-04-30 2019-04-30 Cd73 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024078186A Division JP2024112864A (ja) 2018-04-30 2024-05-13 Ｃｄ７３阻害剤

Publications (3)

Publication Number Publication Date
JP2021522280A JP2021522280A (ja) 2021-08-30
JP2021522280A5 JP2021522280A5 (enExample) 2022-04-26
JP7489323B2 true JP7489323B2 (ja) 2024-05-23

Family

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Family Applications (2)

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JP2020560361A Active JP7489323B2 (ja) 2018-04-30 2019-04-30 Ｃｄ７３阻害剤
JP2024078186A Pending JP2024112864A (ja) 2018-04-30 2024-05-13 Ｃｄ７３阻害剤

Family Applications After (1)

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JP2024078186A Pending JP2024112864A (ja) 2018-04-30 2024-05-13 Ｃｄ７３阻害剤

Country Status (13)

Country Link
US (4) US11325938B2 (enExample)
EP (2) EP4674481A3 (enExample)
JP (2) JP7489323B2 (enExample)
KR (1) KR20210018255A (enExample)
CN (2) CN120699076A (enExample)
AU (1) AU2019261976B2 (enExample)
BR (1) BR112020022068A2 (enExample)
CA (1) CA3098493A1 (enExample)
IL (1) IL304348B2 (enExample)
MX (2) MX2020011542A (enExample)
SG (1) SG11202010790XA (enExample)
TW (1) TW202014182A (enExample)
WO (1) WO2019213174A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024164093A (ja) * 2019-10-30 2024-11-26 オリック ファーマシューティカルズ，インク． Ｃｄ７３阻害剤

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Publication number Priority date Publication date Assignee Title
WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) * 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
IL304348B2 (en) 2018-04-30 2024-08-01 Oric Pharmaceuticals Inc CD73 inhibitors
WO2019232319A1 (en) * 2018-05-31 2019-12-05 Peloton Therapeutics, Inc. Compositions and methods for inhibiting cd73
SG11202012001YA (en) 2018-06-21 2021-01-28 Calithera Biosciences Inc Ectonucleotidase inhibitors and methods of use thereof
MA55556A (fr) 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5
JP7557522B2 (ja) 2019-07-16 2024-09-27 オリック ファーマシューティカルズ，インク． Ｃｄ７３阻害剤
AU2021389685A1 (en) * 2020-11-25 2023-07-06 Risen (Suzhou) Pharma Tech Co., Ltd. Cd73 inhibitors and pharmaceutical uses thereof
EP4353732A1 (en) 2021-05-11 2024-04-17 Xizang Haisco Pharmaceutical Co., Ltd. Small molecular cd73 antagonist and use thereof
WO2024076873A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024076872A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
CN116217644B (zh) * 2023-04-24 2023-08-08 南京颐媛生物医学研究院有限公司 抗冠状病毒核糖核苷类化合物及其制备方法和应用
WO2025162964A1 (en) 2024-01-30 2025-08-07 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of endometriosis
WO2025233264A1 (en) 2024-05-07 2025-11-13 Innate Pharma Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers

Citations (5)

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US20090274686A1 (en) 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
JP2017513955A (ja) 2014-04-25 2017-06-01 ビテ・ファーマシューティカルズ・インコーポレイテッドＶｉｔａｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌治療用のｃｄ７３阻害剤としてのプリン誘導体
WO2018049145A1 (en) 2016-09-09 2018-03-15 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
WO2018067424A1 (en) 2016-10-03 2018-04-12 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
JP2020515559A (ja) 2017-03-31 2020-05-28 ぺロトン セラピューティクス，インク． Ｃｄ７３阻害剤とその使用

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WO2002048165A2 (en) 2000-12-15 2002-06-20 Pharmasset Ltd. Antiviral agents for treatment of flaviviridae infections
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CN104530166B (zh) 2014-12-04 2016-08-24 陕西汉江药业集团股份有限公司 选择性还原4,6-共轭双烯-3-酮甾体化合物的方法
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US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
IL304348B2 (en) 2018-04-30 2024-08-01 Oric Pharmaceuticals Inc CD73 inhibitors
WO2019232319A1 (en) 2018-05-31 2019-12-05 Peloton Therapeutics, Inc. Compositions and methods for inhibiting cd73
SG11202012001YA (en) 2018-06-21 2021-01-28 Calithera Biosciences Inc Ectonucleotidase inhibitors and methods of use thereof
WO2020046813A1 (en) 2018-08-27 2020-03-05 Arcus Biosciences, Inc. Cd73 inhibitors
WO2020257429A1 (en) 2019-06-20 2020-12-24 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
JP7557522B2 (ja) 2019-07-16 2024-09-27 オリック ファーマシューティカルズ，インク． Ｃｄ７３阻害剤
PL4051688T3 (pl) 2019-10-30 2025-09-22 Oric Pharmaceuticals, Inc. Inhibitory cd73

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Publication number Priority date Publication date Assignee Title
US20090274686A1 (en) 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
JP2017513955A (ja) 2014-04-25 2017-06-01 ビテ・ファーマシューティカルズ・インコーポレイテッドＶｉｔａｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌治療用のｃｄ７３阻害剤としてのプリン誘導体
WO2018049145A1 (en) 2016-09-09 2018-03-15 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
WO2018067424A1 (en) 2016-10-03 2018-04-12 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
JP2020515559A (ja) 2017-03-31 2020-05-28 ぺロトン セラピューティクス，インク． Ｃｄ７３阻害剤とその使用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024164093A (ja) * 2019-10-30 2024-11-26 オリック ファーマシューティカルズ，インク． Ｃｄ７３阻害剤
JP7688769B2 (ja) 2019-10-30 2025-06-04 オリック ファーマシューティカルズ，インク． Ｃｄ７３阻害剤

Also Published As

Publication number Publication date
JP2021522280A (ja) 2021-08-30
TW202014182A (zh) 2020-04-16
BR112020022068A2 (pt) 2021-04-20
AU2019261976B2 (en) 2025-01-23
SG11202010790XA (en) 2020-11-27
IL304348B1 (en) 2024-04-01
AU2019261976A1 (en) 2020-12-03
EP3787635A1 (en) 2021-03-10
IL304348B2 (en) 2024-08-01
EP3787635A4 (en) 2022-03-02
CN120699076A (zh) 2025-09-26
US20210047359A1 (en) 2021-02-18
MX2020011542A (es) 2020-11-24
US11807658B2 (en) 2023-11-07
WO2019213174A1 (en) 2019-11-07
CN112423764A (zh) 2021-02-26
JP2024112864A (ja) 2024-08-21
US20220220147A1 (en) 2022-07-14
EP4674481A2 (en) 2026-01-07
MX2023002507A (es) 2023-03-13
CA3098493A1 (en) 2019-11-07
US20240124512A1 (en) 2024-04-18
US11325938B2 (en) 2022-05-10
IL304348A (en) 2023-09-01
EP4674481A3 (en) 2026-03-04
US20250368677A1 (en) 2025-12-04
KR20210018255A (ko) 2021-02-17
EP3787635B1 (en) 2025-09-17

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