JP7475731B2 - カンナビノイドプロドラッグ化合物 - Google Patents

カンナビノイドプロドラッグ化合物 Download PDF

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JP7475731B2
JP7475731B2 JP2022519475A JP2022519475A JP7475731B2 JP 7475731 B2 JP7475731 B2 JP 7475731B2 JP 2022519475 A JP2022519475 A JP 2022519475A JP 2022519475 A JP2022519475 A JP 2022519475A JP 7475731 B2 JP7475731 B2 JP 7475731B2
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alkyl
compound
cancer
group
inhibitors
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Japanese (ja)
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JP2022549502A (ja
Inventor
ジョン，キーラン
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ファーストライト ファーマシューティカルズ，エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/50—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2022519475A 2019-09-26 2020-09-25 カンナビノイドプロドラッグ化合物 Active JP7475731B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024063204A JP7868869B2 (ja) 2019-09-26 2024-04-10 カンナビノイドプロドラッグ化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962906228P 2019-09-26 2019-09-26
US62/906,228 2019-09-26
PCT/US2020/052829 WO2021062231A2 (en) 2019-09-26 2020-09-25 Cannabinoid prodrug compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024063204A Division JP7868869B2 (ja) 2019-09-26 2024-04-10 カンナビノイドプロドラッグ化合物

Publications (2)

Publication Number Publication Date
JP2022549502A JP2022549502A (ja) 2022-11-25
JP7475731B2 true JP7475731B2 (ja) 2024-04-30

Family

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JP2022519475A Active JP7475731B2 (ja) 2019-09-26 2020-09-25 カンナビノイドプロドラッグ化合物
JP2024063204A Active JP7868869B2 (ja) 2019-09-26 2024-04-10 カンナビノイドプロドラッグ化合物

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JP2024063204A Active JP7868869B2 (ja) 2019-09-26 2024-04-10 カンナビノイドプロドラッグ化合物

Country Status (5)

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US (2) US11980602B2 (enExample)
EP (1) EP4034100A4 (enExample)
JP (2) JP7475731B2 (enExample)
CA (1) CA3152168A1 (enExample)
WO (1) WO2021062231A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116234812A (zh) * 2020-11-25 2023-06-06 成都百裕制药股份有限公司 大麻素类化合物的制备方法
CN115315418B (zh) * 2021-04-06 2023-03-21 山东绿叶制药有限公司 大麻二酚前药及其药物组合物和应用
CN116253671B (zh) * 2021-12-10 2025-07-04 德义制药有限公司 一种大麻二酚衍生物及其制备方法和应用
CA3257730A1 (en) * 2022-05-31 2023-12-07 Trait Biosciences, Inc. Compositions of water-soluble cannabinoid prodrugs and their synthesis processes
CN120531715B (zh) * 2025-05-28 2026-03-17 中国人民解放军军事科学院军事医学研究院 大麻二酚在寡肽转运体抑制剂中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008107879A1 (en) 2007-03-05 2008-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel cannabidiol derivatives and their use as anti-inflammatory agents
WO2009018389A1 (en) 2007-07-30 2009-02-05 Alltranz Inc. Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same
WO2018091551A1 (en) 2016-11-15 2018-05-24 Full Spectrum Laboratories Ltd Bio-stable cannabinoid compounds and methods for enhancing their physiological concentration
JP2022535238A (ja) 2019-06-06 2022-08-05 アプライド マテリアルズ インコーポレイテッド 撮像システム及び合成画像を生成する方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6676176B2 (ja) * 2016-01-29 2020-04-08 ユニヴァーシティー オブ ミシシッピ 生物学的に活性なカンナビジオール類似体
CN109311838A (zh) * 2016-04-15 2019-02-05 蒂温诺特技术有限公司 大麻素前药的生物合成

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008107879A1 (en) 2007-03-05 2008-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel cannabidiol derivatives and their use as anti-inflammatory agents
WO2009018389A1 (en) 2007-07-30 2009-02-05 Alltranz Inc. Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same
WO2018091551A1 (en) 2016-11-15 2018-05-24 Full Spectrum Laboratories Ltd Bio-stable cannabinoid compounds and methods for enhancing their physiological concentration
JP2022535238A (ja) 2019-06-06 2022-08-05 アプライド マテリアルズ インコーポレイテッド 撮像システム及び合成画像を生成する方法

Also Published As

Publication number Publication date
EP4034100A4 (en) 2023-10-11
WO2021062231A3 (en) 2021-05-06
WO2021062231A2 (en) 2021-04-01
JP2024088768A (ja) 2024-07-02
JP2022549502A (ja) 2022-11-25
US20240408046A1 (en) 2024-12-12
CA3152168A1 (en) 2021-04-01
EP4034100A2 (en) 2022-08-03
JP7868869B2 (ja) 2026-06-02
US20220211656A1 (en) 2022-07-07
US11980602B2 (en) 2024-05-14

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