CA3152168A1 - Cannabinoid prodrug compounds - Google Patents

Cannabinoid prodrug compounds Download PDF

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Publication number
CA3152168A1
CA3152168A1 CA3152168A CA3152168A CA3152168A1 CA 3152168 A1 CA3152168 A1 CA 3152168A1 CA 3152168 A CA3152168 A CA 3152168A CA 3152168 A CA3152168 A CA 3152168A CA 3152168 A1 CA3152168 A1 CA 3152168A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
aryl
heteroaryl
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3152168A
Other languages
English (en)
French (fr)
Inventor
Kieran John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firstlight Pharmaceuticals LLC
Original Assignee
Firstlight Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firstlight Pharmaceuticals LLC filed Critical Firstlight Pharmaceuticals LLC
Publication of CA3152168A1 publication Critical patent/CA3152168A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/50Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3152168A 2019-09-26 2020-09-25 Cannabinoid prodrug compounds Pending CA3152168A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962906228P 2019-09-26 2019-09-26
US62/906,228 2019-09-26
PCT/US2020/052829 WO2021062231A2 (en) 2019-09-26 2020-09-25 Cannabinoid prodrug compounds

Publications (1)

Publication Number Publication Date
CA3152168A1 true CA3152168A1 (en) 2021-04-01

Family

ID=75166839

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3152168A Pending CA3152168A1 (en) 2019-09-26 2020-09-25 Cannabinoid prodrug compounds

Country Status (5)

Country Link
US (2) US11980602B2 (enExample)
EP (1) EP4034100A4 (enExample)
JP (2) JP7475731B2 (enExample)
CA (1) CA3152168A1 (enExample)
WO (1) WO2021062231A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022111587A1 (zh) * 2020-11-25 2022-06-02 成都百裕制药股份有限公司 大麻素类化合物的制备方法
CN115315418B (zh) * 2021-04-06 2023-03-21 山东绿叶制药有限公司 大麻二酚前药及其药物组合物和应用
CN116253671B (zh) * 2021-12-10 2025-07-04 德义制药有限公司 一种大麻二酚衍生物及其制备方法和应用
EP4531836A1 (en) * 2022-05-31 2025-04-09 Trait Biosciences, Inc. Water-soluble cannabinoid prodrugs compositions and methods of synthesizing the same
CN120531715A (zh) * 2025-05-28 2025-08-26 中国人民解放军军事科学院军事医学研究院 大麻二酚在寡肽转运体抑制剂中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008107879A1 (en) 2007-03-05 2008-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel cannabidiol derivatives and their use as anti-inflammatory agents
ES2534900T3 (es) * 2007-07-30 2015-04-30 Zynerba Pharmaceuticals, Inc. Profármacos de cannabidiol, composiciones que comprenden los profármacos de cannabidiol y métodos de uso de los mismos
NZ745595A (en) * 2016-01-29 2019-12-20 Univ Mississippi Biologically active cannabidiol analogs
EP3442953A1 (en) * 2016-04-15 2019-02-20 Teewinot Technologies Limited Biosynthesis of cannabinoid prodrugs
EP3541772A1 (en) * 2016-11-15 2019-09-25 Teewinot Technologies Limited Bio-stable cannabinoid compounds and methods for enhancing their physiological concentration
US11610925B2 (en) 2019-06-06 2023-03-21 Applied Materials, Inc. Imaging system and method of creating composite images

Also Published As

Publication number Publication date
WO2021062231A3 (en) 2021-05-06
US11980602B2 (en) 2024-05-14
JP2024088768A (ja) 2024-07-02
US20220211656A1 (en) 2022-07-07
JP2022549502A (ja) 2022-11-25
JP7475731B2 (ja) 2024-04-30
US20240408046A1 (en) 2024-12-12
WO2021062231A2 (en) 2021-04-01
EP4034100A4 (en) 2023-10-11
EP4034100A2 (en) 2022-08-03

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