CA3152168A1 - Cannabinoid prodrug compounds - Google Patents
Cannabinoid prodrug compounds Download PDFInfo
- Publication number
- CA3152168A1 CA3152168A1 CA3152168A CA3152168A CA3152168A1 CA 3152168 A1 CA3152168 A1 CA 3152168A1 CA 3152168 A CA3152168 A CA 3152168A CA 3152168 A CA3152168 A CA 3152168A CA 3152168 A1 CA3152168 A1 CA 3152168A1
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- Prior art keywords
- alkyl
- compound
- aryl
- heteroaryl
- cancer
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/50—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962906228P | 2019-09-26 | 2019-09-26 | |
| US62/906,228 | 2019-09-26 | ||
| PCT/US2020/052829 WO2021062231A2 (en) | 2019-09-26 | 2020-09-25 | Cannabinoid prodrug compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3152168A1 true CA3152168A1 (en) | 2021-04-01 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3152168A Pending CA3152168A1 (en) | 2019-09-26 | 2020-09-25 | Cannabinoid prodrug compounds |
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|---|---|
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| EP (1) | EP4034100A4 (enExample) |
| JP (2) | JP7475731B2 (enExample) |
| CA (1) | CA3152168A1 (enExample) |
| WO (1) | WO2021062231A2 (enExample) |
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| WO2022111587A1 (zh) * | 2020-11-25 | 2022-06-02 | 成都百裕制药股份有限公司 | 大麻素类化合物的制备方法 |
| CN115315418B (zh) * | 2021-04-06 | 2023-03-21 | 山东绿叶制药有限公司 | 大麻二酚前药及其药物组合物和应用 |
| CN116253671B (zh) * | 2021-12-10 | 2025-07-04 | 德义制药有限公司 | 一种大麻二酚衍生物及其制备方法和应用 |
| EP4531836A1 (en) * | 2022-05-31 | 2025-04-09 | Trait Biosciences, Inc. | Water-soluble cannabinoid prodrugs compositions and methods of synthesizing the same |
| CN120531715A (zh) * | 2025-05-28 | 2025-08-26 | 中国人民解放军军事科学院军事医学研究院 | 大麻二酚在寡肽转运体抑制剂中的应用 |
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| WO2008107879A1 (en) | 2007-03-05 | 2008-09-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Novel cannabidiol derivatives and their use as anti-inflammatory agents |
| ES2534900T3 (es) * | 2007-07-30 | 2015-04-30 | Zynerba Pharmaceuticals, Inc. | Profármacos de cannabidiol, composiciones que comprenden los profármacos de cannabidiol y métodos de uso de los mismos |
| NZ745595A (en) * | 2016-01-29 | 2019-12-20 | Univ Mississippi | Biologically active cannabidiol analogs |
| EP3442953A1 (en) * | 2016-04-15 | 2019-02-20 | Teewinot Technologies Limited | Biosynthesis of cannabinoid prodrugs |
| EP3541772A1 (en) * | 2016-11-15 | 2019-09-25 | Teewinot Technologies Limited | Bio-stable cannabinoid compounds and methods for enhancing their physiological concentration |
| US11610925B2 (en) | 2019-06-06 | 2023-03-21 | Applied Materials, Inc. | Imaging system and method of creating composite images |
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2020
- 2020-09-25 CA CA3152168A patent/CA3152168A1/en active Pending
- 2020-09-25 JP JP2022519475A patent/JP7475731B2/ja active Active
- 2020-09-25 EP EP20867541.3A patent/EP4034100A4/en active Pending
- 2020-09-25 WO PCT/US2020/052829 patent/WO2021062231A2/en not_active Ceased
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2022
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2024
- 2024-04-10 JP JP2024063204A patent/JP2024088768A/ja active Pending
- 2024-05-13 US US18/662,582 patent/US20240408046A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021062231A3 (en) | 2021-05-06 |
| US11980602B2 (en) | 2024-05-14 |
| JP2024088768A (ja) | 2024-07-02 |
| US20220211656A1 (en) | 2022-07-07 |
| JP2022549502A (ja) | 2022-11-25 |
| JP7475731B2 (ja) | 2024-04-30 |
| US20240408046A1 (en) | 2024-12-12 |
| WO2021062231A2 (en) | 2021-04-01 |
| EP4034100A4 (en) | 2023-10-11 |
| EP4034100A2 (en) | 2022-08-03 |
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