JP7473472B2 - アシアロ糖タンパク質受容体１の発現を阻害するためのＲＮＡｉ剤および組成物 - Google Patents
アシアロ糖タンパク質受容体１の発現を阻害するためのＲＮＡｉ剤および組成物 Download PDFInfo
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- JP7473472B2 JP7473472B2 JP2020521451A JP2020521451A JP7473472B2 JP 7473472 B2 JP7473472 B2 JP 7473472B2 JP 2020521451 A JP2020521451 A JP 2020521451A JP 2020521451 A JP2020521451 A JP 2020521451A JP 7473472 B2 JP7473472 B2 JP 7473472B2
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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| CN116617390A (zh) * | 2022-02-11 | 2023-08-22 | 武汉大学 | Asgr1抑制剂在促进胆固醇外排和治疗非酒精性脂肪性肝病中的应用 |
| CN117645995A (zh) * | 2022-09-02 | 2024-03-05 | 北京福元医药股份有限公司 | 抑制去唾液酸糖蛋白受体基因表达的siRNA、其缀合物和药物组合物及用途 |
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| JP2019524151A (ja) | 2016-08-26 | 2019-09-05 | アムジェン インコーポレイテッド | ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法 |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| EP1159441B8 (en) | 1999-03-10 | 2008-10-29 | Marie Curie Cancer Care | Delivery of nucleic acids and proteins to cells |
| CN1300312C (zh) * | 2004-08-23 | 2007-02-14 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 靶向去唾液酸糖蛋白受体的抗乙型肝炎病毒反义寡核苷酸的结构和用途 |
| BRPI0715375A2 (pt) | 2006-08-18 | 2013-06-18 | Hoffmann La Roche | policonjugados para distribuiÇço in vivo de polinucleotÍdeos |
| WO2008043561A2 (en) * | 2006-10-11 | 2008-04-17 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Influenza targets |
| EP2295543A1 (en) * | 2009-09-11 | 2011-03-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the preparation of an influenza virus |
| ES2562817T3 (es) | 2010-02-24 | 2016-03-08 | Arrowhead Research Corporation | Composiciones para el suministro dirigido de ARNip |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| MX2014001971A (es) | 2011-08-26 | 2014-03-31 | Arrowhead Res Corp | Polimeros de poli(vinilester) para suministro de acido nucleico in vivo. |
| MX2014001965A (es) | 2012-04-18 | 2014-03-31 | Arrowhead Res Corp | Polimeros de poli(acrilato) para suministro de acido nucleico in vivo. |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| CN109069529B (zh) | 2016-03-07 | 2021-08-20 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
| CN109462981B (zh) * | 2016-09-02 | 2023-07-07 | 箭头药业股份有限公司 | 靶向配体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017058944A1 (en) | 2015-09-29 | 2017-04-06 | Amgen Inc. | Asgr inhibitors |
| JP2019524151A (ja) | 2016-08-26 | 2019-09-05 | アムジェン インコーポレイテッド | ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法 |
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| JP2020537653A (ja) | 2020-12-24 |
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| AU2018352379A1 (en) | 2020-06-04 |
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