JP7464526B2 - 4-ヒドロキシピペリジン誘導体およびユビキチン特異的プロテアーゼ19(usp19)の阻害剤としてのその使用 - Google Patents

4-ヒドロキシピペリジン誘導体およびユビキチン特異的プロテアーゼ19(usp19)の阻害剤としてのその使用 Download PDF

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JP7464526B2
JP7464526B2 JP2020541791A JP2020541791A JP7464526B2 JP 7464526 B2 JP7464526 B2 JP 7464526B2 JP 2020541791 A JP2020541791 A JP 2020541791A JP 2020541791 A JP2020541791 A JP 2020541791A JP 7464526 B2 JP7464526 B2 JP 7464526B2
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methyl
hydroxy
azaspiro
decan
carbonyl
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JPWO2019150119A5 (https=
JP2021525220A5 (https=
JP2021525220A (ja
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ジェイムズ・サミュエル・シェイン・ラウントゥリー
スティーブン・クリストファー・ホワイトヘッド
アダム・ピョートル・トリーダー
ローレン・エマ・プロクター
スティーブン・デイビッド・シェパード
フランク・バーカンプ
ホアナ・リタ・カストロ・コスタ
コリン・オダウド
ティモシー・ハリソン
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Almac Discovery Ltd
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/47Quinolines; Isoquinolines
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JP2020541791A 2018-01-31 2019-01-31 4-ヒドロキシピペリジン誘導体およびユビキチン特異的プロテアーゼ19(usp19)の阻害剤としてのその使用 Active JP7464526B2 (ja)

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Application Number Priority Date Filing Date Title
GBGB1801562.8A GB201801562D0 (en) 2018-01-31 2018-01-31 Pharmaceutical compounds
GB1801562.8 2018-01-31
PCT/GB2019/050271 WO2019150119A1 (en) 2018-01-31 2019-01-31 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (usp19)

Publications (4)

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MX2021006542A (es) 2018-12-06 2021-07-07 Almac Discovery Ltd Inhibidores de la usp19 para usarse en terapia.
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