JP2021525220A5 - - Google Patents
Info
- Publication number
- JP2021525220A5 JP2021525220A5 JP2020541791A JP2020541791A JP2021525220A5 JP 2021525220 A5 JP2021525220 A5 JP 2021525220A5 JP 2020541791 A JP2020541791 A JP 2020541791A JP 2020541791 A JP2020541791 A JP 2020541791A JP 2021525220 A5 JP2021525220 A5 JP 2021525220A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- hydroxy
- azaspiro
- decane
- carbonyl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1801562.8A GB201801562D0 (en) | 2018-01-31 | 2018-01-31 | Pharmaceutical compounds |
| GB1801562.8 | 2018-01-31 | ||
| PCT/GB2019/050271 WO2019150119A1 (en) | 2018-01-31 | 2019-01-31 | 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (usp19) |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021525220A JP2021525220A (ja) | 2021-09-24 |
| JPWO2019150119A5 JPWO2019150119A5 (https=) | 2022-02-02 |
| JP2021525220A5 true JP2021525220A5 (https=) | 2022-02-02 |
| JP7464526B2 JP7464526B2 (ja) | 2024-04-09 |
Family
ID=61558043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020541791A Active JP7464526B2 (ja) | 2018-01-31 | 2019-01-31 | ４－ヒドロキシピペリジン誘導体およびユビキチン特異的プロテアーゼ１９（ｕｓｐ１９）の阻害剤としてのその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11807646B2 (https=) |
| EP (1) | EP3746432B1 (https=) |
| JP (1) | JP7464526B2 (https=) |
| KR (1) | KR20200115623A (https=) |
| CN (1) | CN112135818A (https=) |
| AU (1) | AU2019213562A1 (https=) |
| BR (1) | BR112020015449A2 (https=) |
| CA (1) | CA3089538A1 (https=) |
| ES (1) | ES2934958T3 (https=) |
| GB (1) | GB201801562D0 (https=) |
| IL (1) | IL276324A (https=) |
| MX (1) | MX2020008091A (https=) |
| RU (1) | RU2020127848A (https=) |
| SG (1) | SG11202007179SA (https=) |
| WO (1) | WO2019150119A1 (https=) |
| ZA (1) | ZA202004909B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113365696A (zh) * | 2018-12-06 | 2021-09-07 | 阿尔麦克探索有限公司 | 药物化合物和其作为泛素特异性蛋白酶19(usp19)抑制剂的用途 |
| MX2021006542A (es) | 2018-12-06 | 2021-07-07 | Almac Discovery Ltd | Inhibidores de la usp19 para usarse en terapia. |
| EP3965749A4 (en) * | 2019-05-06 | 2023-06-21 | Valo Health, Inc. | ESCAPEMENT OF USP19 |
| GB202104097D0 (en) | 2021-03-24 | 2021-05-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB202311227D0 (en) | 2023-07-21 | 2023-09-06 | Almac Discovery Ltd | Pharmaceutical compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO111096A0 (en) | 1996-07-18 | 1996-08-08 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| ES2309206T3 (es) | 2001-10-02 | 2008-12-16 | Smithkline Beecham Corporation | Compuestos quimicos. |
| FR2873691B1 (fr) | 2004-07-29 | 2006-10-06 | Sanofi Synthelabo | Derives d'amino-piperidine, leur preparation et leur application en therapeutique |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| MA41291A (fr) * | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| AR103297A1 (es) * | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| HK1248220A1 (zh) * | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 喹唑啉酮和偶氮喹唑啉作为泛特丁胺蛋白酶7抑制剂 |
| US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| EP3253765A1 (en) * | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| FR3052452B1 (fr) * | 2016-06-10 | 2018-06-22 | Les Laboratoires Servier | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA3027008C (en) * | 2016-06-10 | 2021-02-09 | Les Laboratoires Servier | (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| GB201612938D0 (en) | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| CN113365696A (zh) * | 2018-12-06 | 2021-09-07 | 阿尔麦克探索有限公司 | 药物化合物和其作为泛素特异性蛋白酶19(usp19)抑制剂的用途 |
-
2018
- 2018-01-31 GB GBGB1801562.8A patent/GB201801562D0/en not_active Ceased
-
2019
- 2019-01-31 RU RU2020127848A patent/RU2020127848A/ru unknown
- 2019-01-31 US US16/965,403 patent/US11807646B2/en active Active
- 2019-01-31 CN CN201980023817.1A patent/CN112135818A/zh active Pending
- 2019-01-31 SG SG11202007179SA patent/SG11202007179SA/en unknown
- 2019-01-31 AU AU2019213562A patent/AU2019213562A1/en not_active Abandoned
- 2019-01-31 JP JP2020541791A patent/JP7464526B2/ja active Active
- 2019-01-31 ES ES19704415T patent/ES2934958T3/es active Active
- 2019-01-31 KR KR1020207025095A patent/KR20200115623A/ko not_active Withdrawn
- 2019-01-31 MX MX2020008091A patent/MX2020008091A/es unknown
- 2019-01-31 BR BR112020015449-0A patent/BR112020015449A2/pt not_active Application Discontinuation
- 2019-01-31 EP EP19704415.9A patent/EP3746432B1/en active Active
- 2019-01-31 CA CA3089538A patent/CA3089538A1/en active Pending
- 2019-01-31 WO PCT/GB2019/050271 patent/WO2019150119A1/en not_active Ceased
-
2020
- 2020-07-27 IL IL276324A patent/IL276324A/en unknown
- 2020-08-07 ZA ZA2020/04909A patent/ZA202004909B/en unknown
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