JP7462574B2 - ジオキセタン化合物及び微生物検出のためのそれらの使用 - Google Patents

ジオキセタン化合物及び微生物検出のためのそれらの使用 Download PDF

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JP7462574B2
JP7462574B2 JP2020567041A JP2020567041A JP7462574B2 JP 7462574 B2 JP7462574 B2 JP 7462574B2 JP 2020567041 A JP2020567041 A JP 2020567041A JP 2020567041 A JP2020567041 A JP 2020567041A JP 7462574 B2 JP7462574 B2 JP 7462574B2
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JP2021525273A (ja
JPWO2019224338A5 (https=
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シャバット，ドロン
エリ ロス－コンフォルティ，ミハル
ハナニヤ，ニール
グリーン，オリ
スピッツ，ウルス
ウィック，ルーカス
イーセン，ジュリアン
ヴォルベルグ，ラファエル
クリビウ，リカルド
バブジャコヴァ，ズザーナ
ヤオ，チュンヤン
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Ramot at Tel Aviv University Ltd
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JP2020567041A 2018-05-25 2019-05-24 ジオキセタン化合物及び微生物検出のためのそれらの使用 Active JP7462574B2 (ja)

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EP18174403 2018-05-25
EP18174403.8 2018-05-25
PCT/EP2019/063418 WO2019224338A1 (en) 2018-05-25 2019-05-24 Dioxetane compounds and their use for the detection of microorganisms

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JPWO2019224338A5 JPWO2019224338A5 (https=) 2023-08-18
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US (2) US11649475B2 (https=)
EP (1) EP3802511A1 (https=)
JP (1) JP7462574B2 (https=)
KR (2) KR20250052483A (https=)
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Publication number Priority date Publication date Assignee Title
CN110944985B (zh) * 2017-05-24 2022-12-13 特拉维夫大学拉玛特有限公司 用于蛋白酶的成像/检测的化学发光探针
US20230094870A1 (en) * 2020-02-19 2023-03-30 Ramot At Tel-Aviv University Ltd. Chemiluminescence probes for tuberculosis
WO2025079067A1 (en) * 2023-10-10 2025-04-17 Ramot At Tel-Aviv University Ltd. Chemiluminescent array-based assay for rapid identification of bacteria and method of use
WO2025191551A1 (en) * 2024-03-13 2025-09-18 Ramot At Tel-Aviv University Ltd. Phenoxy-dioxetanes-based chemiluminescence probes and uses thereof
CN119409748A (zh) * 2025-01-06 2025-02-11 四川省医学科学院·四川省人民医院 一种N-乙酰-β-D-氨基葡萄糖酶的化学发光探针、试剂盒及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139811A2 (en) 2008-05-15 2009-11-19 Tianxin Wang Chemiluminescent methods and reagents for analyte detection
CN102183512A (zh) 2011-02-15 2011-09-14 杭州师范大学 一种基于化学发光原理的活细胞检测方法
CN106279178A (zh) 2016-07-18 2017-01-04 华东理工大学 耐碳青霉烯类抗生素病菌的荧光探针及合成方法与应用
JP2017505612A (ja) 2014-01-17 2017-02-23 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ メタロ−β−ラクタマーゼを発現する細菌を検出するための６，７−トランスセファロスポリンに基づくプローブ
WO2017130191A1 (en) 2016-01-26 2017-08-03 Ramot At Tel-Aviv University Ltd. Chemiluminescent probes for diagnostics and in vivo imaging
JP2020520981A (ja) 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． プロテアーゼのイメージング／検出のための化学発光プローブ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223402A (en) 1990-08-30 1993-06-29 Difco Laboratories Method of detecting microbes utilizing chemiluminescent compound
EP1735621A4 (en) 2004-04-14 2012-12-12 Brij P Giri NEW ULTRA-SENSITIVE CHEMIELUMINESCENSE SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139811A2 (en) 2008-05-15 2009-11-19 Tianxin Wang Chemiluminescent methods and reagents for analyte detection
CN102183512A (zh) 2011-02-15 2011-09-14 杭州师范大学 一种基于化学发光原理的活细胞检测方法
JP2017505612A (ja) 2014-01-17 2017-02-23 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ メタロ−β−ラクタマーゼを発現する細菌を検出するための６，７−トランスセファロスポリンに基づくプローブ
WO2017130191A1 (en) 2016-01-26 2017-08-03 Ramot At Tel-Aviv University Ltd. Chemiluminescent probes for diagnostics and in vivo imaging
CN106279178A (zh) 2016-07-18 2017-01-04 华东理工大学 耐碳青霉烯类抗生素病菌的荧光探针及合成方法与应用
JP2020520981A (ja) 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． プロテアーゼのイメージング／検出のための化学発光プローブ

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Margret Ryan et al.，A chemiluminescent substrate for the detection of phosphatidylinositol-specific phospholipase C，Analytical Biochemistry ，1993年，214，548-56
Michal E. Roth-Konforti et al.，Unprecedented Sensitivity in a Probe for Monitoring Cathepsin B: Chemiluminescence Microscopy Cell-Imaging of a Natively Expressed Enzyme，Angewandte Chemie, International Edition ，2017年，56，15633-15638，DOI: 10.1002/anie.201709347
Nir Hananya et al.，A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes，Angewandte Chemie, International Edition ，2017年，56，16454-16463，DOI: 10.1002/anie.201706969
Tal Eilon-Shaffer et al.，ortho-Chlorination of phenoxy 1,2-dioxetane yields superior chemiluminescent probes for in vitro and in vivo imaging，Organic & Biomolecular Chemistry，2018年，16，1708-1712，DOI: 10.1039/c8ob00087e

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WO2019224338A1 (en) 2019-11-28
JP2021525273A (ja) 2021-09-24
CN112204020A (zh) 2021-01-08
KR20250052483A (ko) 2025-04-18
EP3802511A1 (en) 2021-04-14
US20230265480A1 (en) 2023-08-24
US11649475B2 (en) 2023-05-16
US20210214766A1 (en) 2021-07-15
CN112204020B (zh) 2023-11-14

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