JP7461054B2 - 菌類病原体を予防及び防除するための殺真菌剤 - Google Patents
菌類病原体を予防及び防除するための殺真菌剤 Download PDFInfo
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- JP7461054B2 JP7461054B2 JP2020572855A JP2020572855A JP7461054B2 JP 7461054 B2 JP7461054 B2 JP 7461054B2 JP 2020572855 A JP2020572855 A JP 2020572855A JP 2020572855 A JP2020572855 A JP 2020572855A JP 7461054 B2 JP7461054 B2 JP 7461054B2
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- isothiocyanato
- methylsulfinyl
- octane
- methylsulfonyl
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
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- 239000005416 organic matter Substances 0.000 description 1
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000004934 phenanthridinyl group Chemical group C1(=CC=CC2=NC=C3C=CC=CC3=C12)* 0.000 description 1
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- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 description 1
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
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- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
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- MRWGDPZZBCERIT-DHPXDJSUSA-M potassium;[(e)-[5-methylsulfonyl-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylpentylidene]amino] sulfate Chemical compound [K+].CS(=O)(=O)CCCC\C(=N/OS([O-])(=O)=O)S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O MRWGDPZZBCERIT-DHPXDJSUSA-M 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
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- 235000015136 pumpkin Nutrition 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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- 125000003003 spiro group Chemical group 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- ROZUQUDEWZIBHV-UHFFFAOYSA-N tecloftalam Chemical compound OC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C(=O)NC1=CC=CC(Cl)=C1Cl ROZUQUDEWZIBHV-UHFFFAOYSA-N 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
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- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
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- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 108010058651 thioglucosidase Proteins 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
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- ZTWIEIFKPFJRLV-UHFFFAOYSA-K trichlororuthenium;trihydrate Chemical compound O.O.O.Cl[Ru](Cl)Cl ZTWIEIFKPFJRLV-UHFFFAOYSA-K 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- KBMBVTRWEAAZEY-UHFFFAOYSA-N trisulfane Chemical compound SSS KBMBVTRWEAAZEY-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/46—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=C=S groups
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- A61K31/33—Heterocyclic compounds
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
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- A61K31/33—Heterocyclic compounds
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- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Description
Zは、ニトリル(-CN)、チオシアネート(-SCN)又はイソチオシアネート(-N=C=S)を表し、
X、Yは、互いに独立に、孤立電子対又はOを表すが、ただしこの2つのX又はYのうちの少なくとも1つはOであり、
R1、R2は、互いに独立に、H、飽和の直鎖状、環状又は分枝状の(C1~C6)アルキルを表し、
A、Cは、互いに独立に、共有結合、飽和又は不飽和の直鎖状、環状、スピロ環式、二環式、多環式若しくは分枝状の(C1~C8)アルキル、C6-アリールを表し、
Bは、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表すが、
ただし、A、B又はCのうちの少なくとも1つは共有結合とは異なり、かつ上記少なくとも2種の組み合わされた化合物は、
1)イソチオシアネートを表す少なくとも1つのZ基、及び/又は
2)上記硫黄原子の少なくとも2つの異なる酸化のレベル、及び/又は
3)少なくとも上記炭素鎖残基-A-B-C-における異なる長さ
を含むことを特徴とする組成物の使用を提供することである。
Zは、ニトリル(-CN)、チオシアネート(-SCN)又はイソチオシアネート(-N=C=S)を表し、
X、Yは、互いに独立に、孤立電子対又はOを表すが、ただしこの2つのX又はYのうちの少なくとも1つはOであり、
R1、R2は、互いに独立に、H、飽和の直鎖状、環状又は分枝状の(C1~C6)アルキルを表し、
A、Cは、互いに独立に、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表し、
Bは、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表すが、
ただし、A、B又はCのうちの少なくとも1つは共有結合とは異なり、かつ上記少なくとも2種の組み合わされた化合物は、
1)イソチオシアネートを表す少なくとも1つのZ基、及び/又は
2)上記硫黄原子の少なくとも2つの異なる酸化のレベル、及び/又は
3)少なくとも上記炭素鎖残基-A-B-C-における異なる長さ
を含むことを特徴とする使用。
シクロアルキル環は、種々の位置、及びその環に対してシス(cis)又はトランス(trans)の位置で置換されていてもよく、
脂肪族及び芳香族は、H、ハロゲン又はOMe基で置換されていてもよい。
式(I)中、
Zは、イソチオシアネート(-N=C=S)を表し、
X、Yは、互いに独立にOを表し、
R1、R2は、互いに独立に、H、飽和の直鎖状又は環状の(C1~C6)アルキルを表し、
A、Cは、互いに独立に、共有結合、飽和若しくは不飽和の直鎖状又は環状の(C1~C8)アルキルを表すが、ただしA又はCのうちの少なくとも1つは共有結合とは異なり、
Bは、共有結合を表し、
炭素鎖残基-A-B-C-における長さはC3~C9である
使用を提供する。
1)イソチオシアネートを表す少なくとも1つのZ基、及び/又は
2)上記硫黄原子の少なくとも2つの異なる酸化のレベル、及び/又は
3)少なくとも上記炭素鎖残基-A-B-C-における異なる長さ
を含み、
4)上記炭素鎖残基-A-B-C-における長さはC3~C9である
使用を提供する。
Zは、ニトリル(-CN)、チオシアネート(-SCN)又はイソチオシアネート(-N=C=S)を表し、
X、Yは、互いに独立に、孤立電子対又はOを表すが、ただしこの2つのX又はYのうちの少なくとも1つはOであり、
R1、R2は、互いに独立に、H、飽和の直鎖状、環状又は分枝状の(C1~C6)アルキルを表し、
A、Cは、互いに独立に、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表し、
Bは、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表すが、
ただし、A、B又はCのうちの少なくとも1つは共有結合とは異なり、
上記少なくとも2種の組み合わされた化合物は、
1)イソチオシアネートを表す少なくとも1つのZ基、及び/又は
2)上記硫黄原子の少なくとも2つの異なる酸化のレベル、及び/又は
3)少なくとも上記炭素鎖残基-A-B-C-における異なる長さ
を含むことを特徴とする組成物を提供することが本発明の別の目的である。
Zは、ニトリル(-CN)、チオシアネート(-SCN)又はイソチオシアネート(-N=C=S)を表し、
X、Yは、互いに独立に、孤立電子対又はOを表すが、ただしこの2つのX又はYのうちの少なくとも1つはOであり、
R1、R2は、互いに独立に、H、飽和の直鎖状、環状又は分枝状の(C1~C6)アルキルを表し、
A、Cは、互いに独立に、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表し、
Bは、共有結合、飽和若しくは不飽和の直鎖状、環状、スピロ環式、二環式、多環式又は分枝状の(C1~C8)アルキル、C6-アリールを表すが、
ただし、A、B又はCのうちの少なくとも1つは共有結合とは異なり、
上記少なくとも2種の組み合わされた化合物は、
1)イソチオシアネートを表す少なくとも1つのZ基、及び/又は
2)上記硫黄原子の少なくとも2つの異なる酸化のレベル、及び/又は
3)少なくとも上記炭素鎖残基-A-B-C-における異なる長さ
を含むことを特徴とする組成物を提供することが本発明のさらに別の目的である。
Zは、イソチオシアネート(-N=C=S)を表し、
X、Yは、互いに独立にOを表し、
R1、R2は、互いに独立に、H、飽和の直鎖状又は環状の(C1~C6)アルキルを表し、
A、Cは、互いに独立に、共有結合、飽和若しくは不飽和の直鎖状又は環状の(C1~C8)アルキルを表すが、ただしA又はCのうちの少なくとも1つは共有結合とは異なり、
Bは、共有結合を表し、
上記炭素鎖残基-A-B-C-における長さはC3~C9である
一般式Iから選択される少なくとも2種の化合物の組み合わせを含む。
1)イソチオシアネートを表す少なくとも1つのZ基、及び/又は
2)上記硫黄原子の少なくとも2つの異なる酸化のレベル、及び/又は
3)少なくとも上記炭素鎖残基-A-B-C-における異なる長さ
を含み、
上記炭素鎖残基-A-B-C-における長さはC3~C9である。
野生型(WT)植物として、シロイヌナズナ系統Columbia-0(Col-0)を用いた。Col-0バックグラウンドにおける以下の対立遺伝子をArabidopsis Biological Resource Centre(ABRC)から受け取った:fad2-1(CS8041)、fad2-3(SK18137)、fad2-1 fad6及びfad2-3 fad6をこの研究における単一変異体の交配により得た。二重変異体gpat4 gpat8は、Frederic Beissonによって好意により提供され、fad3-2 fad7-2 fad8種子は、John Browseによって提供され、cyp77 dcr及びgpat6 pec1二重変異体は、Christiane Nawrath博士によって好意により提供された。植える前に、種子を40℃で2日間、土中で保存し、次いで、用途に応じた光期間(実生苗による実験:14時間明、10時間暗(長日);種子繁殖のための土壌上:24時間明、連続日中)を用いて100μE m-2s-1の光で21℃で成長させた。
本研究では、2株のボトリティス・シネレアを用いた:それぞれChristiane Nawrath博士及びMichael Hahn教授によって提供されたBMM及びB05.10。上記真菌をジャガイモデキストロース寒天(PDA)上で10日間増殖させた。分生子を濾過し、1/2量ジャガイモデキストロースブロス(PDB)中で5×105胞子/μlに希釈した。2μlのこの懸濁液をペトリ皿で生育した7日齢のシロイヌナズナの子葉に施用した。感染した実生苗を長日条件下で48時間インキュベーションした。
メチルスルホニル及びメチルスルフィニルニトリル及びチオシアネートを、SpiroChem(スピロケム)(バーゼル(Basel)、スイス)から、メチルスルホニル及びメチルスルフィニルイソチオシアネートをSpiroChem及びLKT LABS(エルケーティー・ラボ)(ミネソタ州、米国)から得た。得た化合物は全てジメチルスルホキシド(DMSO)に溶解した。インビトロ真菌バイオアッセイのために使用した真菌株は、Agroscopeのmycotheca(マイコテカ)(www.mycoscope.bcis.ch)から得た。
Synapt G2四重極飛行時間型質量分析計質量分析計(QTOF;Waters(ウォーターズ))につないだAcquity超高性能液体クロマトグラフィー(UPLC)での超高性能液体クロマトグラフィー-四重極飛行時間型質量分析(UPLC/QTOF-MS)を使用してこの実験を実施した。Acquity UPLCエチレンブリッジハイブリッド(BEH) C18カラム(50×2.1mm、1.7μm;Waters)を400μL/分の流量で用い、25℃の温度に維持した。移動相Aとしての水の中の0.05% ギ酸及び移動相Bとしてのアセトニトリルの中の0.05% ギ酸を用いて以下の勾配を使用した:0.0~7.0分 2~100% B、7.0~9.0分 100% B、9.0~11.0分 2% B。注入量は2.5μLであった。QTOFは、MSE(フルスキャン及びすべてのフラグメントイオンの同時取得)モードを使用してエレクトロスプレーネガティブモードで動作した。質量分析のパラメータは以下のとおりであった:質量範囲85~1200Da、スキャン時間0.2s、ソース温度120℃、キャピラリー電圧-2.0kV、コーン電圧-25V、エクストラクションコーン(extraction cone)-4.5V、脱溶媒和ガスフロー及び温度、それぞれ800L/h及び400℃、コーンガスフロー 20L/h、衝突エネルギー4eV(低エネルギー取得機能)及び10~35eV(高エネルギー取得機能)、衝突ガス(アルゴン) 7×10-3mbars。正確な質量測定を確保するために、水:アセトニトリル:ギ酸(50:50:0.1)中の合成ペプチド、ロイシン-エンケファリンの400ng/mL溶液を、内部基準として質量分析計へ絶えず注入した。データをMasslynx v.4.1(Waters)によって記録した。以下のパラメータを用いてMarkerlynx XS(Waters)を使用してマーカー検出を実施した:初期保持時間及び最終保持時間 0.0及び9.0分、質量範囲85~1200Da、質量ウィンドウ 0.02Da、保持時間ウィンドウ 0.06分、強度閾値 500カウント、自動ピーク幅及びピーク・トゥ・ピークベースラインノイズ算出、同位体消去機能を適用。データは、主成分分析を適用する前に、平均中心処理し(mean-centered)、Paretoスケーリング処理をした。注目するマーカーを、その分子式決定及び衝突誘起解離によって得られたフラグメントに基づいて仮に特定した。
7-メチルスルホニル-ヘプチルグルコシノレートは、子葉段階で殺生性菌類病原体ボトリティス・シネレアに対する強い耐性を明らかにした脂肪酸不飽和化酵素2(fad2-3)シロイヌナズナ変異体の表面で特定された(図1)。ボトリティス・シネレア及び他の菌類病原体に対する7-メチルスルホニル-ヘプチルイソチオシアネート(7MSOOH、7-メチルスルホニル-ヘプチルグルコシノレートの唯一の市販の副生成物)の抗真菌活性の確認を、異なる投与量のジャガイモデキストロース寒天中のイソチオシアネートの直接施用によってインビトロで行った。得られた結果は、10~1500μMの用量範囲でボトリティス・シネレアに対するこの化合物の真菌毒性活性がないことを明らかにした。この化合物の潜在的な毒性効果のために、より高い投与量は適用しなかった。しかしながら、他の真菌病原体に対するバイオアッセイの性能は、7-メチルスルホニル-ヘプチルイソチオシアネートが、表1に示すように、いくつかの真菌種に対して真菌毒性であることを特定することを可能にした。
グルコシノレートの他の天然の副生成物及びそれらの組み合わせを検討することにより、出願人らは、化合物の非常に効率的な抗真菌性混合物を特定した。出願人らは、分析した化合物の対真菌毒性活性を検討するために、1500μMの最大濃度で個体群の95%において定量的効果をもたらす有効用量(ED95)を使用した。出願人らは、毒性アッセイを実施するために、2種の最も広範に広がっている植物菌類病原体を選んだ:ボトリティス・シネレア(1400種の植物種の病原体)及びフザリウム・オキシスポラム(非常に多くの植物種、例えばトマト、バナナの病原体)。このような菌類病原体を選んだのは、市場において何らの効率的な有機的処理が存在しない(60%未満の効率)ことからであり、このことは、農業者の健康にとって及び環境にとってもリスクなしに農業者が使用することができる新しい効率的な生成物を特定する必要性を作り出している。
他の脂肪族イソチオシアネートの検討により、出願人らは、6-メチルスルホニルヘキシルイソチオシアネート(6MSOOH)と、6-メチルスルフィニルヘキシル(6MSOH)イソチオシアネート、4-メチルスルフィニルブチル(4MSOH)イソチオシアネート、8-メチルスルフィニルオクチル(8MSOH)イソチオシアネート及び8-メチルスルホニルオクチル(8MSOOH)イソチオシアネートとの組み合わせを、フザリウム・グラミネウム(大麦及び小麦の病原体)及びフィトフトラ・カクトラム(Phytophthora cactorum)(200種の植物種の病原体)に対するそれらの対真菌毒性効果について試験した。
1H NMR(300MHz、クロロホルム-d) δ 1.26-1.45(m,6H),1.50-1.67(m,2H),2.00-2.08(m,2H),2.09(s,3H),2.44-2.54(m,2H),4.84-5.06(m,2H),5.68-5.90(m,1H)。
1H NMR(300MHz、クロロホルム-d) δ 1.34-1.56(m,4H),1.66(m,2H),1.79-1.93(m,2H),2.37(t,J=7.3Hz,2H),2.90(s,3H),2.95-3.07(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 1.35-1.51(m,6H),1.57(m,2H),1.86(m,2H),2.90(s,3H),2.96-3.07(m,2H),3.65(td,J=6.5,1.0Hz,2H)。
1H NMR(300MHz、クロロホルム-d) δ 1.34-1.53(m,6H),1.68-1.94(m,4H),2.90(s,3H),2.96-3.06(m,5H),4.18-4.27(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 1.35-1.55(m,6H),1.84(m,4H),2.91(s,3H),2.94(t,J=7.2Hz,2H),2.98-3.05(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 1.33-1.55(m,6H),1.60-1.74(m,2H),1.79-1.94(m,2H),2.35(td,J=7.0,0.6Hz,2H),2.90(s,3H),2.96-3.05(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 7.89-7.80(m,2H),7.77-7.66(m,2H),3.75-3.63(m,2H),3.44-3.31(m,2H),1.99-1.84(m,2H),1.79-1.63(m,2H),1.60-1.42(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 7.90-7.80(m,2H),7.78-7.66(m,2H),3.74-3.63(m,2H),2.54-2.42(m,2H),2.08(s,3H),1.80-1.57(m,5H),1.52-1.37(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 7.89-7.82(m,2H),7.77-7.68(m,2H),3.71(t,J=7.0Hz,2H),3.07-2.95(m,3H),2.93-2.87(m,4H),1.99-1.86(m,2H),1.82-1.67(m,2H),1.61-1.43(m,2H)。
1H NMR(300MHz、クロロホルム-d) δ 3.56(t,J=6.3Hz,2H),3.10-3.00(m,2H),2.93(d,J=0.7Hz,3H),1.98-1.86(m,2H),1.83-1.70(m,2H),1.68-1.53(m,2H)。
多様な炭素長を有するイソチオシアネートと、スルフィニル又はスルホニル基との自然の組み合わせの検討により、出願人らは、化合物の非常に効率的な抗真菌性混合物を特定した。出願人らは、分析する化合物の対真菌毒性活性を検討するために、1500μMの最大濃度で個体群の95%において定量的効果をもたらす有効用量(ED95)を使用した。出願人らは、毒性アッセイを実施するために、2番目に最も広範に広がっている植物菌類病原体であるボトリティス・シネレア(1400種の植物種の病原体)を選んだ。その理由は、それが全世界に分布していることと、この菌類病原体を処置するための十分な量の効率的な有機物が存在しないことであった。
単独及び組み合わせの脂肪族イソチオシアネートの対真菌毒性特性の検討により、出願人らは、8-メチルスルホニル-オクチル-(8MSOOH)イソチオシアネート及び8-メチルスルフィニル-オクチル-(8MSOH)イソチオシアネートの活性を深く検討した。出願人らは、フザリウム・グラミネウム(大麦及び小麦の病原体)、フィトフトラ・インフェスタンス(ナスの病原体)及びギグナルディア・ビドウェリイ(ブドウの病原体)を使用して対真菌毒性の研究を行った。
3つの殺生性真菌種における組み合わされたイソチオシアネートの対真菌毒性活性
出願人らは、3種の殺生性真菌種、すなわちアルテルナリア・ラデキナ(綱:クロイボタケ綱;目:プレオスポラ目;宿主:ニンジン)、フザリウム・グラミネウム(綱:フンタマカビ綱;目:ボタンタケ目;宿主:穀草類)及びプレクトスファエレラ・ククメリナ(綱:フンタマカビ綱;目:グロメレラ目(Glomerellales);宿主:トマト及びウリ)における組み合わされたイソチオシアネートの対真菌毒性活性を検討した。全体としては、合計で133個の組み合わせをこれら3つの真菌種に対して試験した。
プラスモパラ・ビチコラ(綱:卵菌綱;目:ツユカビ目;ブドウの生体栄養性病原体)を用いるインビボ真菌バイオアッセイ
1-イソチオシアナト-8-(メチルスルホニル)-オクタン及び1-イソチオシアナト-8-(メチルスルフィニル)-オクタンはSpiroChem(バーゼル、スイス)から得た。これらの化合物はジメチルスルホキシド(DMSO)に溶解した。
トリコフィトン・ルブルム(綱:ユーロチウム菌綱;目:ホネタケ目;ヒトの皮膚及び爪の病原体)
1-イソチオシアナト-8-(メチルスルホニル)-オクタン及び1-イソチオシアナト-8-(メチルスルフィニル)-オクタンはSpiroChem(バーゼル、スイス)から得た。これらの化合物はジメチルスルホキシド(DMSO)に溶解した。
サムニディウム・エレガンス(綱 接合菌綱(Zygomycetes);目 ムコール目;保存した食肉)
1-イソチオシアナト-8-(メチルスルホニル)-オクタン及び1-イソチオシアナト-8-(メチルスルフィニル)-オクタンはSpiroChem(バーゼル、スイス)から得た。これらの化合物はジメチルスルホキシド(DMSO)に溶解した。
1. Schreiner RP, Koide RT. 1993a. Antifungal compounds from the roots of mycotrophic and non-mycotrophic plant species. New Phytol. 123:99-105.
2. Dufour V, Stahl M, Baysse C. 2015. The antibacterial properties of isothiocyanates. Mycrobiol. 161(Pt 2):229-43.
3. Lambrix V, Reichelt M, Mitchell-Olds T, Kliebenstein DJ, Gershenzon J. 2001. The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. Plant Cell. 13(12):2793-807.
4. Schnee S, Queiroz EF, Voinesco F, Marcourt L, Dubuis P-H, Wolfender J-L, Gindro K. 2013. Vitis vinifera canes, a new source of antifungal compounds against Plasmopora viticola, Erysiphe necator, and Botrytis cinerea. J.Agric.Food Chem. 61(23):5459-67.
5. Chou TC. 2006. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58:621-681、2006.
Claims (13)
- 植物における菌類病原体の予防又は処置における、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-8-(メチルスルホニル)-オクタン、1-(イソチオシアナトメチル)-3-(4-(メチルスルフィニル)ブチル)ベンゼン/1-(イソチオシアナトメチル)-3-(4-(メチルスルホニル)ブチル)ベンゼン、(E)-1-イソチオシアナト-8-(メチルスルフィニル)オクト-2-エン/1-イソチオシアナト-3-(メチルスルフィニル)-プロパン、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-7-(メチルスルフィニル)-ヘプタン、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-6-(メチルスルフィニル)-ヘキサン、(E)-1-イソチオシアナト-8-(メチルスルフィニル)オクト-2-エン/1-イソチオシアナト-8-(メチルスルフィニル)-オクタン、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-9-(メチルスルホニル)-ノナン、1-(エチルスルフィニル)-8-イソチオシアナトオクタン/1-イソチオシアナト-7-(メチルスルフィニル)-ヘプタン、1-(エチルスルフィニル)-8-イソチオシアナトオクタン/1-イソチオシアナト-3-(メチルスルフィニル)-プロパン、1-イソチオシアナト-8-(メチルスルホニル)-オクタン/1-イソチオシアナト-7-(メチルスルフィニル)-ヘプタン、1-イソチオシアナト-8-(メチルスルホニル)-オクタン/1-イソチオシアナト-9-(メチルスルフィニル)-ノナン、1-イソチオシアナト-8-(メチルスルホニル)-オクタン/1-イソチオシアナト-3-(メチルスルフィニル)-プロパン、又は、(E)-1-イソチオシアナト-8-(メチルスルフィニル)オクト-2-エン/1-(エチルスルフィニル)-8-イソチオシアナトオクタンからなる群から選択される少なくとも2種の化合物の組み合わせを含む組成物の使用。
- 前記少なくとも2種の化合物の組み合わせが、1-イソチオシアナト-8-(メチルスルホニル)-オクタン及び1-イソチオシアナト-8-(メチルスルフィニル)-オクタンの混合物であることを特徴とする請求項1に記載の組成物の使用。
- 前記組成物が植物において対真菌毒性及び/又は静真菌性であることを特徴とする請求項1又は請求項2に記載の組成物の使用。
- 屋外での植物培養における、又は植物培養のインビトロでの実施のための請求項1から請求項3のいずれか1項に記載の組成物の使用。
- 食品又は飲料における抗カビ剤としての、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-8-(メチルスルホニル)-オクタンからなる2種の化合物の組み合わせを含む組成物の使用。
- 経口衛生用品又はサニタリー用品における消毒薬組成物であって、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-8-(メチルスルホニル)-オクタンからなる2種の化合物の組み合わせを含む消毒薬組成物。
- 前記経口衛生用品が、歯磨剤、トローチ剤、液体又は粉末の口腔洗浄薬、コーティング溶液、口臭予防剤、チューインガムの中から選択される請求項6に記載の消毒薬組成物。
- ヒト又は動物の患者において真菌症を予防又は治療する方法において使用するための、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-8-(メチルスルホニル)-オクタンからなる2種の化合物の組み合わせを含む、使用するための組成物。
- 前記真菌症が、トリコフィトン・ルブルムの感染に起因する請求項8に記載の使用するための組成物。
- 1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-8-(メチルスルホニル)-オクタン、1-(イソチオシアナトメチル)-3-(4-(メチルスルフィニル)ブチル)ベンゼン/1-(イソチオシアナトメチル)-3-(4-(メチルスルホニル)ブチル)ベンゼン、(E)-1-イソチオシアナト-8-(メチルスルフィニル)オクト-2-エン/1-イソチオシアナト-3-(メチルスルフィニル)-プロパン、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-7-(メチルスルフィニル)-ヘプタン、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-6-(メチルスルフィニル)-ヘキサン、(E)-1-イソチオシアナト-8-(メチルスルフィニル)オクト-2-エン/1-イソチオシアナト-8-(メチルスルフィニル)-オクタン、1-イソチオシアナト-8-(メチルスルフィニル)-オクタン/1-イソチオシアナト-9-(メチルスルホニル)-ノナン、1-(エチルスルフィニル)-8-イソチオシアナトオクタン/1-イソチオシアナト-7-(メチルスルフィニル)-ヘプタン、1-(エチルスルフィニル)-8-イソチオシアナトオクタン/1-イソチオシアナト-3-(メチルスルフィニル)-プロパン、1-イソチオシアナト-8-(メチルスルホニル)-オクタン/1-イソチオシアナト-7-(メチルスルフィニル)-ヘプタン、1-イソチオシアナト-8-(メチルスルホニル)-オクタン/1-イソチオシアナト-9-(メチルスルフィニル)-ノナン、1-イソチオシアナト-8-(メチルスルホニル)-オクタン/1-イソチオシアナト-3-(メチルスルフィニル)-プロパン、又は、(E)-1-イソチオシアナト-8-(メチルスルフィニル)オクト-2-エン/1-(エチルスルフィニル)-8-イソチオシアナトオクタンからなる群から選択される少なくとも2種の化合物の組み合わせを含む殺真菌剤組成物。
- 前記少なくとも2種の化合物の組み合わせが、1-イソチオシアナト-8-(メチルスルホニル)-オクタン及び1-イソチオシアナト-8-(メチルスルフィニル)-オクタンの混合物であることを特徴とする請求項10に記載の殺真菌剤組成物。
- 許容できる担体又は希釈剤と組み合わせた請求項10又は請求項11に記載の殺真菌剤組成物。
- 前記殺真菌剤組成物が、担子菌門、接合菌門、卵菌門又は子嚢菌門を含む門から選択される植物菌類病原体に対して活性である請求項10から請求項12のいずれか1項に記載の殺真菌剤組成物。
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CA3223518A1 (en) | 2021-07-05 | 2023-01-12 | Agrosustain Sa | Synergy between mixtures of isothiocyanates and commercial fungicides |
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