JP7458159B2

JP7458159B2 - 眼科組成物

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Info

Publication number: JP7458159B2
Authority: JP; Japan
Prior art keywords: composition; ophthalmic composition; salts; component; epinastine
Prior art date: 2018-09-28
Legal status : Active

Application number

JP2019163363A

Other languages

English (en)

Japanese (ja)

Other versions

JP2020055799A (ja

Inventor

敏行堀田

雅俊羽賀

Current Assignee

Rohto Pharmaceutical Co Ltd

Original Assignee

Rohto Pharmaceutical Co Ltd

Priority date

2018-09-28

Filing date

2019-09-06

Publication date

2024-03-29

2019-09-06 Application filed by Rohto Pharmaceutical Co Ltd filed Critical Rohto Pharmaceutical Co Ltd

2020-04-09 Publication of JP2020055799A publication Critical patent/JP2020055799A/ja

2024-03-18 Priority to JP2024041957A priority Critical patent/JP7624538B2/ja

2024-03-29 Application granted granted Critical

2024-03-29 Publication of JP7458159B2 publication Critical patent/JP7458159B2/ja

2025-01-20 Priority to JP2025007374A priority patent/JP2025061470A/ja

Status Active legal-status Critical Current

2039-09-06 Anticipated expiration legal-status Critical

Links

239000000203 mixture Substances 0.000 title claims description 300
150000003839 salts Chemical class 0.000 claims description 140
-1 polyethylene terephthalate Polymers 0.000 claims description 76
WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 claims description 71
229960003449 epinastine Drugs 0.000 claims description 62
238000000034 method Methods 0.000 claims description 58
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NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 37
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 37
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
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229920000139 polyethylene terephthalate Polymers 0.000 claims description 11
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BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 claims description 2
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CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
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FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 6
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150000007513 acids Chemical class 0.000 description 5
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JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 4
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