JP7450295B2 - 表面改質されたガス-生成ナノ粒子を用いた脂肪分解用組成物 - Google Patents
表面改質されたガス-生成ナノ粒子を用いた脂肪分解用組成物 Download PDFInfo
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- JP7450295B2 JP7450295B2 JP2022538223A JP2022538223A JP7450295B2 JP 7450295 B2 JP7450295 B2 JP 7450295B2 JP 2022538223 A JP2022538223 A JP 2022538223A JP 2022538223 A JP2022538223 A JP 2022538223A JP 7450295 B2 JP7450295 B2 JP 7450295B2
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Description
Claims (9)
- 表面改質されたガス-生成ナノ粒子を含む脂肪分解用薬学組成物であって、
脂肪細胞標的指向性又は細胞透過性ペプチドにより表面改質された生体適合性高分子;及び
前記生体適合性高分子の内部に封入された細粒炭酸カルシウム(Fine-grained Calcium Carbonate)結晶を含み、
前記ペプチドは、配列番号1~6のうちいずれか一つで記載されるアミノ酸配列からなることを特徴とする、脂肪分解用薬学組成物。 - 前記表面改質されたガス-生成ナノ粒子は、脂肪細胞内に選択的に移入された後に脂肪細胞を死滅させることを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 前記表面改質されたガス-生成ナノ粒子は、脂肪細胞を除外した他の細胞を死滅させないことを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 前記表面改質は、前記生体適合性高分子末端アミン基と前記ペプチド末端アミン基のカルボジイミド結合によることを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 前記生体適合性高分子は、ポリラクチド(PLA)、ポリグリコリド(PGA)、ポリラクチド-ポリグリコリド共重合体(PLGA)、澱粉、グリコーゲン、キチン、ペプチドグリカン、リグノスルホネート、タンニン酸、リグニン、ペクチン、ポリエチレングリコール、ポリエチレンオキシド、ポリビニルアルコール、ポリエチレンオキシド-ポリプロピレンオキシドブロック共重合体、セルロース、ヘミセルロース、ヘパリン、ヒアルロン酸、デキストラン及びアルジネートからなる群より選択された構造を有する重合体であることを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 前記ペプチド及び前記生体適合性高分子のモル比は、0.05:1~1:1であることを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 前記薬学組成物内の前記細粒炭酸カルシウム結晶の濃度は、0.01(w/v)%~10(w/v)%であることを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 前記薬学組成物は、注射剤又は経皮投与剤の形態であることを特徴とする、請求項1に記載の脂肪分解用薬学組成物。
- 表面改質されたガス-生成ナノ粒子を含む脂肪分解用化粧料組成物であって、
脂肪細胞標的指向性又は細胞透過性ペプチドにより表面改質された生体適合性高分子;及び
前記生体適合性高分子の内部に封入された細粒炭酸カルシウム(Fine-grained Calcium Carbonate)結晶を含み、
前記ペプチドは、配列番号1~6のうちいずれか一つで記載されるアミノ酸配列からなることを特徴とする、脂肪分解用化粧料組成物。
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KR10-2019-0171012 | 2019-12-19 | ||
PCT/KR2020/010187 WO2021125488A1 (ko) | 2019-12-19 | 2020-08-03 | 표면 개질된 가스-생성 나노입자를 이용한 지방 분해용 조성물 |
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MX2022008595A (es) * | 2020-01-15 | 2022-08-10 | Supernova Bio Co Ltd | Micela generadora de gas para reducir grasa localizada. |
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