JP7448122B2 - 口腔内フローラ改善・維持剤、プラーク/歯垢の除去及び歯石形成予防剤 - Google Patents
口腔内フローラ改善・維持剤、プラーク/歯垢の除去及び歯石形成予防剤 Download PDFInfo
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- 239000006072 paste Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 210000002379 periodontal ligament Anatomy 0.000 description 1
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- 239000000661 sodium alginate Substances 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Birds (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Description
<実施形態1>
<概要>
<構成>
<グラム陰性菌>
<グラム陽性菌>
<口腔内バイオフィルム>
<初期付着菌や仲介菌の特性>
<口臭>
<口腔内フローラのバランス異常>
<カンジダ症>
<誤嚥性肺炎>
<感染性心内膜症>
<その他の口腔内フローラが関与する疾病>
<口腔内の不衛生化>
<歯周病>
<P. gingivalisなどが炎症を起こすメカニズム>
<歯周病の先に>
<口腔内バイオフィルム形成について補足>
<実施形態1 試験>
<試験方法>
<微生物の前培養>
<バイオフィルム形成阻害試験>
<バイオフィルム除去試験>
<試験結果 バイオフィルム形成阻害>
<試験結果 バイオフィルム除去>
<飲食料>
<口腔洗浄剤>
<歯磨剤>
Claims (11)
- プロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とする初期付着菌によるバイオフィルム形成の阻害・除去剤。
- プロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とするグラム陰性菌又は/及びグラム陽性菌の口腔内バイオフィルム(プラーク、歯垢)からの離脱を促進する請求項1に記載の初期付着菌によるバイオフィルム形成の阻害・除去剤。
- プロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とするグラム陰性菌又は/及びグラム陽性菌の口腔内バイオフィルム(プラーク、歯垢)の形成を抑制する請求項1に記載の初期付着菌によるバイオフィルム形成の阻害・除去剤。
- 前記グラム陰性菌又は/及びグラム陽性菌は、Streptococcus gordonii、Streptococcus mitis、Fusobacterium nucleatum、Porphyromonas gingivalis、Treponema spp、Tannerella forsythiaのうちの少なくとも二以上を含む請求項2又は請求項3に記載の初期付着菌によるバイオフィルム形成の阻害・除去剤。
- 請求項1から請求項4のいずれか一に記載のプロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とする初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用飲食料。
- 請求項1から請求項4のいずれか一に記載のプロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とする初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用口腔洗浄剤。
- 請求項1から請求項4のいずれか一に記載のプロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とする初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用歯磨剤。
- プロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とする初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用歯石形成予防剤。
- プロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とするグラム陰性菌又は/及びグラム陽性菌の口腔内バイオフィルムからの離脱を促進する請求項8に記載の初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用歯石形成予防剤。
- プロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とするグラム陰性菌又は/及びグラム陽性菌の口腔内バイオフィルムの形成を抑制する請求項8に記載の初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用歯石形成予防剤。
- 前記グラム陰性菌又は/及びグラム陽性菌は、Streptococcus gordonii、Streptococcus mitis、Fusobacterium nucleatum、Porphyromonas gingivalis、Treponema spp、Tannerella forsythiaのうちの少なくとも二以上を含む請求項9又は請求項10に記載のプロアントシアニジンを有効な主成分とするアカシアの樹皮抽出物を有効成分とする初期付着菌によるバイオフィルム形成の阻害・除去剤を含有した初期付着菌によるバイオフィルム形成の阻害・除去用歯石形成予防剤。
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PCT/JP2021/031820 WO2022054629A1 (ja) | 2020-09-10 | 2021-08-31 | 口腔内フローラ改善・維持剤、プラーク/歯垢の除去及び歯石形成予防剤 |
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Citations (9)
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JP2005232153A (ja) | 2004-01-21 | 2005-09-02 | Toyo Shinyaku:Kk | スフィンゴ脂質を有効成分とする樹皮抽出物成分の吸収促進剤 |
US20070258913A1 (en) | 2004-09-17 | 2007-11-08 | Bart Rossel | Composition for Inhibiting or Preventing the Formation of a Biofilm |
JP2008517069A (ja) | 2004-10-19 | 2008-05-22 | ユニゲン・ファーマシューティカルス・インコーポレーテッド | 口腔疾患および状態の予防または処置に用いるための二重エイコサノイド系・サイトカイン系阻害剤の製剤 |
US20090185987A1 (en) | 2008-01-21 | 2009-07-23 | Himalaya Global Holdings Ltd. | Herbal dental care composition, method of manufacturing the same and use thereof |
JP2009203209A (ja) | 2008-02-29 | 2009-09-10 | Mimozax Co Ltd | アカシア属樹皮由来物を含有する血糖降下及び/又は抗肥満組成物 |
JP2010105923A (ja) | 2008-10-28 | 2010-05-13 | Mimozax Co Ltd | アカシア属樹皮由来物を含有するPPARδ発現促進剤 |
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JPH07242555A (ja) * | 1994-03-08 | 1995-09-19 | Suntory Ltd | グルコシルトランスフェラーゼ阻害剤およびこれを有効成分として含有する抗う蝕剤並びに抗う蝕性食品 |
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