JP7447011B2 - エフェクターｔ細胞をリプログラムするためのヒストン修飾因子の使用 - Google Patents
エフェクターｔ細胞をリプログラムするためのヒストン修飾因子の使用 Download PDFInfo
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| KR102069704B1 (ko) * | 2018-05-16 | 2020-01-23 | 고려대학교 산학협력단 | Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법 |
| US20210290742A1 (en) * | 2018-09-27 | 2021-09-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods of using lysine deacetylase (kdac) inhibition to generate antigen specific memory t cell responses for durable immunotherapy |
| WO2021222479A1 (en) | 2020-04-28 | 2021-11-04 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| KR20230019460A (ko) * | 2020-05-29 | 2023-02-08 | 상하이 준셀 테라퓨틱스 컴퍼니 리미티드 | 종양 침윤 림프구의 종자세포 배지 및 이의 용도 |
| GB202008957D0 (en) * | 2020-06-12 | 2020-07-29 | Autolus Ltd | Culture medium |
| CN113502265B (zh) * | 2021-05-25 | 2024-05-28 | 昭泰英基生物医药（香港）有限公司 | 将t细胞重编程为类nk细胞的诱导剂及其应用 |
| US20250248946A1 (en) * | 2022-04-15 | 2025-08-07 | Turn Biotechnologies, Inc. | Methods and compositions for immune cell rejuvenation and therapies using rejuvenated immune cells |
| EP4519418A1 (en) * | 2022-05-05 | 2025-03-12 | Immatics US, Inc. | Methods for improving t cell efficacy |
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| WO2017219150A1 (en) | 2016-06-24 | 2017-12-28 | Mcmaster University | Adoptive cell transfer and oncolytic virus combination therapy |
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| US6307024B1 (en) | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| IL292038B2 (en) * | 2014-04-23 | 2024-12-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| BR112020018049A2 (pt) * | 2018-03-07 | 2020-12-29 | Poseida Therapeutics, Inc. | Composições de cartirina e métodos para uso |
| US12173317B2 (en) * | 2018-03-28 | 2024-12-24 | Board Of Regents, The University Of Texas System | Use of histone modifiers to reprogram effector T cells |
| CA3111384A1 (en) | 2018-09-05 | 2020-03-12 | Poseida Therapeutics, Inc. | Allogeneic cell compositions and methods of use |
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Patent Citations (1)
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Non-Patent Citations (5)
| Title |
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| BAE, J et al.，Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors，Leukemia，2018年02月，Vol. 32，pp. 1932-1947 |
| HO, LP et al.，The Road to Memory: An Early Rest for the Long Journey，The Journal of Immunology，2013年，Vol. 191, No. 11，pp. 5603-5614 |
| LOSCHINSKI, R et al.，IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner，Oncotarget，2018年02月，Vol. 9, No. 17，pp. 13125-13138 |
| McCAW, TR et al.，Modulation of antitumor immunity with histone deacetylase inhibitors，Immunotherapy，2017年，Vol. 9, No. 16，pp. 1359-1372 |
| SODRE, AL et al.，Abstract 638: Epigenetic reprograming of immune cells through selective inhibition of HDAC6 reduces suppressive phenotypes and augments anti-tumor properties of T-cells，Cancer Res，2017年，Vol. 77, 13_Supplement，638 |
Cited By (1)
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| JP2024037880A (ja) * | 2018-03-28 | 2024-03-19 | ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム | エフェクターｔ細胞をリプログラムするためのヒストン修飾因子の使用 |
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| CN112105368A (zh) | 2020-12-18 |
| US20250145953A1 (en) | 2025-05-08 |
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| EP3773626B1 (en) | 2026-01-28 |
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| JP2021519087A (ja) | 2021-08-10 |
| EP3773626A1 (en) | 2021-02-17 |
| AU2019243578B2 (en) | 2025-11-20 |
| US12173317B2 (en) | 2024-12-24 |
| US20210189337A1 (en) | 2021-06-24 |
| EP4722350A2 (en) | 2026-04-08 |
| KR20200138325A (ko) | 2020-12-09 |
| KR20260109954A (ko) | 2026-07-13 |
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