JP7441002B2 - リポソーム製剤のためのｐ－エトキシ核酸 - Google Patents

リポソーム製剤のためのｐ－エトキシ核酸 Download PDF

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JP7441002B2
JP7441002B2 JP2018539236A JP2018539236A JP7441002B2 JP 7441002 B2 JP7441002 B2 JP 7441002B2 JP 2018539236 A JP2018539236 A JP 2018539236A JP 2018539236 A JP2018539236 A JP 2018539236A JP 7441002 B2 JP7441002 B2 JP 7441002B2
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composition
oligonucleotides
oligonucleotide
therapy
population
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JP2018534361A (ja
JP2018534361A5 (OSRAM
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ピーター ニールセン，
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バイオ－パス ホールディングス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
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    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
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    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2018539236A 2015-10-14 2016-10-14 リポソーム製剤のためのｐ－エトキシ核酸 Active JP7441002B2 (ja)

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JP2021205957A JP2022027993A (ja) 2015-10-14 2021-12-20 リポソーム製剤のためのｐ－エトキシ核酸

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US201562241503P 2015-10-14 2015-10-14
US62/241,503 2015-10-14
PCT/US2016/057148 WO2017066643A1 (en) 2015-10-14 2016-10-14 P-ethoxy nucleic acids for liposomal formulation

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JP2018534361A JP2018534361A (ja) 2018-11-22
JP2018534361A5 JP2018534361A5 (OSRAM) 2019-11-21
JP7441002B2 true JP7441002B2 (ja) 2024-02-29

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JP2021205957A Withdrawn JP2022027993A (ja) 2015-10-14 2021-12-20 リポソーム製剤のためのｐ－エトキシ核酸

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US (5) US9744187B2 (OSRAM)
EP (1) EP3362563A1 (OSRAM)
JP (2) JP7441002B2 (OSRAM)
KR (1) KR102755601B1 (OSRAM)
CN (1) CN108291227A (OSRAM)
AU (1) AU2016340123B2 (OSRAM)
CO (1) CO2018004821A2 (OSRAM)
EA (1) EA038277B1 (OSRAM)
HK (1) HK1258370A1 (OSRAM)
IL (1) IL258625B2 (OSRAM)
MX (1) MX2018004637A (OSRAM)
SG (2) SG11201802718PA (OSRAM)
WO (1) WO2017066643A1 (OSRAM)

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WO2016164916A1 (en) 2015-04-10 2016-10-13 Thomas Jefferson University Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory m2 monocytes
SG11201802718PA (en) 2015-10-14 2018-05-30 Bio Path Holdings Inc P-ethoxy nucleic acids for liposomal formulation
CN109963571A (zh) 2016-09-16 2019-07-02 拜奥-帕斯控股股份有限公司 含有脂质体反义寡核苷酸的组合疗法
KR102925388B1 (ko) 2017-03-09 2026-02-11 토마스 제퍼슨 유니버시티 안티센스를 사용하여 암을 치료하기 위한 방법 및 조성물
EA201992490A1 (ru) 2017-04-19 2020-03-03 Байо-Пат Холдингз, Инк. Р-этокси нуклеиновые кислоты для ингибирования bcl2
AU2018255352B2 (en) * 2017-04-19 2023-11-16 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for STAT3 inhibition
CA3060090A1 (en) * 2017-04-19 2018-10-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for igf-1r inhibition
CN110650727A (zh) * 2017-04-19 2020-01-03 拜奥-帕斯控股股份有限公司 用于igf-1r抑制的p-乙氧基核酸
US20210052875A1 (en) 2018-01-24 2021-02-25 Thomas Jefferson University Biodiffusion chamber

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