JP7434616B2 - プロドラッグおよびその使用 - Google Patents

プロドラッグおよびその使用 Download PDF

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Publication number
JP7434616B2
JP7434616B2 JP2023007479A JP2023007479A JP7434616B2 JP 7434616 B2 JP7434616 B2 JP 7434616B2 JP 2023007479 A JP2023007479 A JP 2023007479A JP 2023007479 A JP2023007479 A JP 2023007479A JP 7434616 B2 JP7434616 B2 JP 7434616B2
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amino
compound
chem
substituent
amide
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Japanese (ja)
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JP2023106355A (ja
JP2023106355A5 (enExample
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パトリック・ジェイムズ・ナー
ブライアン・パトリック・ファイナン
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2023007479A 2022-01-20 2023-01-20 プロドラッグおよびその使用 Active JP7434616B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023203905A JP2024015148A (ja) 2022-01-20 2023-12-01 プロドラッグおよびその使用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263301311P 2022-01-20 2022-01-20
US63/301,311 2022-01-20
EP22154309 2022-01-31
EP22154309 2022-01-31

Related Child Applications (1)

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JP2023203905A Division JP2024015148A (ja) 2022-01-20 2023-12-01 プロドラッグおよびその使用

Publications (3)

Publication Number Publication Date
JP2023106355A JP2023106355A (ja) 2023-08-01
JP2023106355A5 JP2023106355A5 (enExample) 2023-11-24
JP7434616B2 true JP7434616B2 (ja) 2024-02-20

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JP2023007479A Active JP7434616B2 (ja) 2022-01-20 2023-01-20 プロドラッグおよびその使用
JP2023203905A Pending JP2024015148A (ja) 2022-01-20 2023-12-01 プロドラッグおよびその使用

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JP2023203905A Pending JP2024015148A (ja) 2022-01-20 2023-12-01 プロドラッグおよびその使用

Country Status (7)

Country Link
US (2) US11840560B2 (enExample)
EP (1) EP4466069A1 (enExample)
JP (2) JP7434616B2 (enExample)
KR (2) KR102704620B1 (enExample)
AR (1) AR128315A1 (enExample)
TW (1) TW202330584A (enExample)
WO (1) WO2023139187A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202511291A (zh) 2023-09-11 2025-03-16 丹麥商諾佛 儂迪克股份有限公司 抗ｉｌ－６結構域之抗體
WO2025114501A1 (en) * 2023-11-30 2025-06-05 Novo Nordisk A/S Tri-agonists of the glp-1, gip, and amylin receptors
WO2025252197A1 (zh) * 2024-06-07 2025-12-11 江苏恒瑞医药股份有限公司 药物组合物

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JP2015504431A (ja) 2011-11-17 2015-02-12 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルココルチコイド受容体の活性を示すグルカゴンスーパーファミリーのペプチド
JP2022527803A (ja) 2019-04-11 2022-06-06 ジエンス ハンセン ファーマセウティカル グループ カンパニー リミテッド マルチ受容体刺激剤及びその医療上の使用
JP2023534131A (ja) 2020-07-22 2023-08-08 ノヴォ ノルディスク アー／エス 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬

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WO2010071807A1 (en) 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
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AR084558A1 (es) 2010-12-22 2013-05-22 Marcadia Biotech Metodos para tratar trastornos metabolicos y obesidad con peptidos basados en glucagon activos para el receptor de peptido insulinotropico dependiente de glucosa (gip)/peptido-1 similar al glucagon (glp-1)
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JOP20200119A1 (ar) * 2015-01-09 2017-06-16 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1
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JP2023534131A (ja) 2020-07-22 2023-08-08 ノヴォ ノルディスク アー／エス 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬

Also Published As

Publication number Publication date
US20240083965A1 (en) 2024-03-14
US11840560B2 (en) 2023-12-12
JP2023106355A (ja) 2023-08-01
US20230227521A1 (en) 2023-07-20
TW202330584A (zh) 2023-08-01
KR20230112568A (ko) 2023-07-27
AR128315A1 (es) 2024-04-17
KR102704620B1 (ko) 2024-09-12
JP2024015148A (ja) 2024-02-01
KR20230159805A (ko) 2023-11-22
WO2023139187A1 (en) 2023-07-27
EP4466069A1 (en) 2024-11-27

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