JP7434328B2 - シトルリン化されたヒストン２ａ及び／又は４に結合する抗体 - Google Patents

シトルリン化されたヒストン２ａ及び／又は４に結合する抗体 Download PDF

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JP7434328B2
JP7434328B2 JP2021534820A JP2021534820A JP7434328B2 JP 7434328 B2 JP7434328 B2 JP 7434328B2 JP 2021534820 A JP2021534820 A JP 2021534820A JP 2021534820 A JP2021534820 A JP 2021534820A JP 7434328 B2 JP7434328 B2 JP 7434328B2
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antibody
seq
binding fragment
amino acid
antibodies
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JP2021535211A (ja
JPWO2020038963A5 (https=
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マリア ヘンドリック ラーツ、ジョセフ
ジェラルドゥス シルヴァノ シリヴィ、レナート
ロスマレン、ヨハネス ウィルヘルムス ジェラルドゥス ヴァン
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シトリル ビー．ヴィ．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2021534820A 2018-08-21 2019-08-20 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体 Active JP7434328B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024016700A JP7835788B2 (ja) 2018-08-21 2024-02-06 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1813597.0A GB201813597D0 (en) 2018-08-21 2018-08-21 Antibody
GB1813597.0 2018-08-21
GB1900983.6 2019-01-24
GBGB1900983.6A GB201900983D0 (en) 2019-01-24 2019-01-24 Antibody
PCT/EP2019/072302 WO2020038963A1 (en) 2018-08-21 2019-08-20 Antibodies binding to citrullinated histone 2a and/or 4

Related Child Applications (1)

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JP2024016700A Division JP7835788B2 (ja) 2018-08-21 2024-02-06 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体

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JP2021535211A JP2021535211A (ja) 2021-12-16
JPWO2020038963A5 JPWO2020038963A5 (https=) 2022-08-29
JP2021535211A5 JP2021535211A5 (https=) 2022-08-29
JP7434328B2 true JP7434328B2 (ja) 2024-02-20

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JP2021534820A Active JP7434328B2 (ja) 2018-08-21 2019-08-20 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体
JP2024016700A Active JP7835788B2 (ja) 2018-08-21 2024-02-06 シトルリン化されたヒストン２ａ及び／又は４に結合する抗体

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US (3) US20210395350A1 (https=)
EP (2) EP3841120B1 (https=)
JP (2) JP7434328B2 (https=)
KR (2) KR102871821B1 (https=)
CN (2) CN120058926A (https=)
AU (3) AU2019326740B2 (https=)
CA (1) CA3110013A1 (https=)
DK (1) DK3841120T3 (https=)
ES (1) ES3048210T3 (https=)
FI (1) FI3841120T3 (https=)
HR (1) HRP20251346T1 (https=)
IL (2) IL280995B2 (https=)
LT (1) LT3841120T (https=)
MX (3) MX2025007881A (https=)
PT (1) PT3841120T (https=)
RS (1) RS67385B1 (https=)
SG (1) SG11202101652PA (https=)
SI (1) SI3841120T1 (https=)
SM (1) SMT202500388T1 (https=)
WO (1) WO2020038963A1 (https=)
ZA (1) ZA202101051B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
AU2016303688B2 (en) 2015-07-31 2023-06-15 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2020038963A1 (en) 2018-08-21 2020-02-27 Modiquest B.V. Antibodies binding to citrullinated histone 2a and/or 4
SG11202103001PA (en) 2018-10-05 2021-04-29 Res Inst Nationwide Childrens Hospital Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application
WO2021209465A1 (en) * 2020-04-14 2021-10-21 Universiteit Maastricht Peptide for the treatment of net-associated diseases
CN116096239B (zh) * 2020-07-07 2025-09-02 国家儿童医院研究所 治疗和预防生物膜的联合疗法
GB202012326D0 (en) 2020-08-07 2020-09-23 Citryll B V Diagnostic
WO2022233931A1 (en) 2021-05-04 2022-11-10 Citryll B.V. Inhibition of eosinophilic traps
EP4085973A1 (en) 2021-05-04 2022-11-09 Citryll B.V. Inhibition of eosinophil extracellular traps
EP4442705A1 (en) 2023-04-03 2024-10-09 Citryll B.V. Dosage
GB202318703D0 (en) * 2023-12-07 2024-01-24 Citryll B V Diagnostic agent

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2013513374A (ja) 2009-12-10 2013-04-22 モディクエスト べー． フェー． シトルリン化エピトープに対する抗炎症剤
JP2018502903A (ja) 2014-12-11 2018-02-01 モディクエスト べー．フェー．Ｍｏｄｉｑｕｅｓｔ Ｂ．Ｖ． 特発性肺線維症の治療方法
JP2018523827A (ja) 2015-08-06 2018-08-23 ノビミューン エスアー Ｔｌｒ４依存性障害の診断および処置のための患者集団を特定するための方法および組成物

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KR20130108481A (ko) 2005-08-19 2013-10-02 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
WO2009040562A1 (en) 2007-09-26 2009-04-02 Ucb Pharma S.A. Dual specificity antibody fusions
AU2009253923B2 (en) 2008-06-04 2014-02-13 Citryll B.V. Anti-inflammatory agents
HRP20170374T1 (hr) 2008-09-26 2017-05-05 Ucb Biopharma Sprl Biološki proizvodi
US20120283415A1 (en) 2009-09-10 2012-11-08 Ucb Pharma S.A. Multivalent Antibodies
GB201410520D0 (en) * 2014-06-12 2014-07-30 Univ London Queen Mary Antibody
WO2020038963A1 (en) 2018-08-21 2020-02-27 Modiquest B.V. Antibodies binding to citrullinated histone 2a and/or 4
WO2022233931A1 (en) 2021-05-04 2022-11-10 Citryll B.V. Inhibition of eosinophilic traps
CN117396221A (zh) * 2021-05-04 2024-01-12 奇特里尔私人有限公司 嗜酸性粒细胞陷阱的抑制

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2013513374A (ja) 2009-12-10 2013-04-22 モディクエスト べー． フェー． シトルリン化エピトープに対する抗炎症剤
JP2018502903A (ja) 2014-12-11 2018-02-01 モディクエスト べー．フェー．Ｍｏｄｉｑｕｅｓｔ Ｂ．Ｖ． 特発性肺線維症の治療方法
JP2018523827A (ja) 2015-08-06 2018-08-23 ノビミューン エスアー Ｔｌｒ４依存性障害の診断および処置のための患者集団を特定するための方法および組成物

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Title
PATEL, C.N., et al.，"N+1 engineering of an aspartate isomerization hotspot in the complementarity-determing region of a monoclonal antibody."，JOURNAL OF PHARM. SCI.，2016年，Vol.105，pp.512-518，DOI: 10.1016/S0022-3549(15)00185-9

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CN112930356A (zh) 2021-06-08
SI3841120T1 (sl) 2025-12-31
HRP20251346T1 (hr) 2025-12-19
CA3110013A1 (en) 2020-02-27
US11345750B2 (en) 2022-05-31
SG11202101652PA (en) 2021-03-30
DK3841120T3 (da) 2025-10-20
WO2020038963A1 (en) 2020-02-27
JP2021535211A (ja) 2021-12-16
US12590143B2 (en) 2026-03-31
KR20250148711A (ko) 2025-10-14
US20210395350A1 (en) 2021-12-23
RS67385B1 (sr) 2025-11-28
AU2019326740B2 (en) 2025-11-27
EP3841120B1 (en) 2025-09-24
ZA202101051B (en) 2022-08-31
PT3841120T (pt) 2025-10-20
IL280995A (en) 2021-04-29
SMT202500388T1 (it) 2025-11-10
US20210403543A1 (en) 2021-12-30
AU2026201302A1 (en) 2026-03-12
KR102871821B1 (ko) 2025-10-16
AU2026201303A1 (en) 2026-03-12
MX2025007882A (es) 2025-08-01
JP2024059670A (ja) 2024-05-01
MX2025007881A (es) 2025-08-01
IL322482A (en) 2025-09-01
JP7835788B2 (ja) 2026-03-25
IL280995B2 (en) 2026-01-01
EP4659807A3 (en) 2026-03-18
CN112930356B (zh) 2025-03-21
IL280995B1 (en) 2025-09-01
ES3048210T3 (en) 2025-12-09
EP3841120A1 (en) 2021-06-30
AU2019326740A1 (en) 2021-03-18
FI3841120T3 (fi) 2025-11-03
KR20210056355A (ko) 2021-05-18
MX2021001902A (es) 2021-05-27
CN120058926A (zh) 2025-05-30
LT3841120T (lt) 2025-11-10
US20230183327A1 (en) 2023-06-15
EP4659807A2 (en) 2025-12-10

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