KR102871821B1 - 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체 - Google Patents

시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체

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Publication number
KR102871821B1
KR102871821B1 KR1020217008362A KR20217008362A KR102871821B1 KR 102871821 B1 KR102871821 B1 KR 102871821B1 KR 1020217008362 A KR1020217008362 A KR 1020217008362A KR 20217008362 A KR20217008362 A KR 20217008362A KR 102871821 B1 KR102871821 B1 KR 102871821B1
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antibody
ser
gly
leu
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KR20210056355A (ko
Inventor
요제프 마리아 헨드릭 래츠
레나토 제라두스 실바노 치리비
요하네스 윌헬무스 제라두스 반 로스말렌
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씨트릴 비.브이.
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Priority claimed from GBGB1813597.0A external-priority patent/GB201813597D0/en
Priority claimed from GBGB1900983.6A external-priority patent/GB201900983D0/en
Application filed by 씨트릴 비.브이. filed Critical 씨트릴 비.브이.
Priority to KR1020257029356A priority Critical patent/KR20250148711A/ko
Publication of KR20210056355A publication Critical patent/KR20210056355A/ko
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Publication of KR102871821B1 publication Critical patent/KR102871821B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1020217008362A 2018-08-21 2019-08-20 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체 Active KR102871821B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257029356A KR20250148711A (ko) 2018-08-21 2019-08-20 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1813597.0A GB201813597D0 (en) 2018-08-21 2018-08-21 Antibody
GB1813597.0 2018-08-21
GB1900983.6 2019-01-24
GBGB1900983.6A GB201900983D0 (en) 2019-01-24 2019-01-24 Antibody
PCT/EP2019/072302 WO2020038963A1 (en) 2018-08-21 2019-08-20 Antibodies binding to citrullinated histone 2a and/or 4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257029356A Division KR20250148711A (ko) 2018-08-21 2019-08-20 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체

Publications (2)

Publication Number Publication Date
KR20210056355A KR20210056355A (ko) 2021-05-18
KR102871821B1 true KR102871821B1 (ko) 2025-10-16

Family

ID=67688785

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020217008362A Active KR102871821B1 (ko) 2018-08-21 2019-08-20 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체
KR1020257029356A Pending KR20250148711A (ko) 2018-08-21 2019-08-20 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257029356A Pending KR20250148711A (ko) 2018-08-21 2019-08-20 시트룰린화된 히스톤 2a 및/또는 4에 결합하는 항체

Country Status (21)

Country Link
US (3) US20210395350A1 (https=)
EP (2) EP3841120B1 (https=)
JP (2) JP7434328B2 (https=)
KR (2) KR102871821B1 (https=)
CN (2) CN120058926A (https=)
AU (3) AU2019326740B2 (https=)
CA (1) CA3110013A1 (https=)
DK (1) DK3841120T3 (https=)
ES (1) ES3048210T3 (https=)
FI (1) FI3841120T3 (https=)
HR (1) HRP20251346T1 (https=)
IL (2) IL280995B2 (https=)
LT (1) LT3841120T (https=)
MX (3) MX2025007881A (https=)
PT (1) PT3841120T (https=)
RS (1) RS67385B1 (https=)
SG (1) SG11202101652PA (https=)
SI (1) SI3841120T1 (https=)
SM (1) SMT202500388T1 (https=)
WO (1) WO2020038963A1 (https=)
ZA (1) ZA202101051B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
AU2016303688B2 (en) 2015-07-31 2023-06-15 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2020038963A1 (en) 2018-08-21 2020-02-27 Modiquest B.V. Antibodies binding to citrullinated histone 2a and/or 4
SG11202103001PA (en) 2018-10-05 2021-04-29 Res Inst Nationwide Childrens Hospital Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application
WO2021209465A1 (en) * 2020-04-14 2021-10-21 Universiteit Maastricht Peptide for the treatment of net-associated diseases
CN116096239B (zh) * 2020-07-07 2025-09-02 国家儿童医院研究所 治疗和预防生物膜的联合疗法
GB202012326D0 (en) 2020-08-07 2020-09-23 Citryll B V Diagnostic
WO2022233931A1 (en) 2021-05-04 2022-11-10 Citryll B.V. Inhibition of eosinophilic traps
EP4085973A1 (en) 2021-05-04 2022-11-09 Citryll B.V. Inhibition of eosinophil extracellular traps
EP4442705A1 (en) 2023-04-03 2024-10-09 Citryll B.V. Dosage
GB202318703D0 (en) * 2023-12-07 2024-01-24 Citryll B V Diagnostic agent

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2013513374A (ja) 2009-12-10 2013-04-22 モディクエスト べー． フェー． シトルリン化エピトープに対する抗炎症剤
WO2015189638A2 (en) 2014-06-12 2015-12-17 Queen Mary University Of London Antibody
JP2018502903A (ja) 2014-12-11 2018-02-01 モディクエスト べー．フェー．Ｍｏｄｉｑｕｅｓｔ Ｂ．Ｖ． 特発性肺線維症の治療方法

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
KR20130108481A (ko) 2005-08-19 2013-10-02 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
WO2009040562A1 (en) 2007-09-26 2009-04-02 Ucb Pharma S.A. Dual specificity antibody fusions
AU2009253923B2 (en) 2008-06-04 2014-02-13 Citryll B.V. Anti-inflammatory agents
HRP20170374T1 (hr) 2008-09-26 2017-05-05 Ucb Biopharma Sprl Biološki proizvodi
US20120283415A1 (en) 2009-09-10 2012-11-08 Ucb Pharma S.A. Multivalent Antibodies
US20170038381A1 (en) * 2015-08-06 2017-02-09 Novimmune Sa Methods and compositions for identifying patient populations for diagnosis and treatment of tlr4-dependent disorders
WO2020038963A1 (en) 2018-08-21 2020-02-27 Modiquest B.V. Antibodies binding to citrullinated histone 2a and/or 4
WO2022233931A1 (en) 2021-05-04 2022-11-10 Citryll B.V. Inhibition of eosinophilic traps
CN117396221A (zh) * 2021-05-04 2024-01-12 奇特里尔私人有限公司 嗜酸性粒细胞陷阱的抑制

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2013513374A (ja) 2009-12-10 2013-04-22 モディクエスト べー． フェー． シトルリン化エピトープに対する抗炎症剤
WO2015189638A2 (en) 2014-06-12 2015-12-17 Queen Mary University Of London Antibody
JP2018502903A (ja) 2014-12-11 2018-02-01 モディクエスト べー．フェー．Ｍｏｄｉｑｕｅｓｔ Ｂ．Ｖ． 特発性肺線維症の治療方法

Also Published As

Publication number Publication date
CN112930356A (zh) 2021-06-08
SI3841120T1 (sl) 2025-12-31
HRP20251346T1 (hr) 2025-12-19
CA3110013A1 (en) 2020-02-27
US11345750B2 (en) 2022-05-31
SG11202101652PA (en) 2021-03-30
DK3841120T3 (da) 2025-10-20
WO2020038963A1 (en) 2020-02-27
JP2021535211A (ja) 2021-12-16
US12590143B2 (en) 2026-03-31
KR20250148711A (ko) 2025-10-14
US20210395350A1 (en) 2021-12-23
RS67385B1 (sr) 2025-11-28
AU2019326740B2 (en) 2025-11-27
EP3841120B1 (en) 2025-09-24
ZA202101051B (en) 2022-08-31
PT3841120T (pt) 2025-10-20
IL280995A (en) 2021-04-29
JP7434328B2 (ja) 2024-02-20
SMT202500388T1 (it) 2025-11-10
US20210403543A1 (en) 2021-12-30
AU2026201302A1 (en) 2026-03-12
AU2026201303A1 (en) 2026-03-12
MX2025007882A (es) 2025-08-01
JP2024059670A (ja) 2024-05-01
MX2025007881A (es) 2025-08-01
IL322482A (en) 2025-09-01
JP7835788B2 (ja) 2026-03-25
IL280995B2 (en) 2026-01-01
EP4659807A3 (en) 2026-03-18
CN112930356B (zh) 2025-03-21
IL280995B1 (en) 2025-09-01
ES3048210T3 (en) 2025-12-09
EP3841120A1 (en) 2021-06-30
AU2019326740A1 (en) 2021-03-18
FI3841120T3 (fi) 2025-11-03
KR20210056355A (ko) 2021-05-18
MX2021001902A (es) 2021-05-27
CN120058926A (zh) 2025-05-30
LT3841120T (lt) 2025-11-10
US20230183327A1 (en) 2023-06-15
EP4659807A2 (en) 2025-12-10

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