JP7425448B2 - ハロゲノギ酸ハロゲン化アルキルエステルの製造方法 - Google Patents
ハロゲノギ酸ハロゲン化アルキルエステルの製造方法 Download PDFInfo
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- JP7425448B2 JP7425448B2 JP2020556159A JP2020556159A JP7425448B2 JP 7425448 B2 JP7425448 B2 JP 7425448B2 JP 2020556159 A JP2020556159 A JP 2020556159A JP 2020556159 A JP2020556159 A JP 2020556159A JP 7425448 B2 JP7425448 B2 JP 7425448B2
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- halogenated
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- producing
- halogenated alkyl
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- 239000002253 acid Substances 0.000 title claims description 30
- 238000004519 manufacturing process Methods 0.000 title claims description 25
- 125000005907 alkyl ester group Chemical group 0.000 title claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 86
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 56
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical group ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 44
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 35
- 239000001301 oxygen Substances 0.000 claims description 35
- 229910052760 oxygen Inorganic materials 0.000 claims description 35
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 32
- 150000001298 alcohols Chemical class 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 16
- 150000002148 esters Chemical class 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims description 10
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 claims description 8
- 230000000269 nucleophilic effect Effects 0.000 claims description 8
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 7
- 230000001678 irradiating effect Effects 0.000 claims description 6
- OEBXWWBYZJNKRK-UHFFFAOYSA-N 1-methyl-2,3,4,6,7,8-hexahydropyrimido[1,2-a]pyrimidine Chemical compound C1CCN=C2N(C)CCCN21 OEBXWWBYZJNKRK-UHFFFAOYSA-N 0.000 claims description 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 5
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 claims description 4
- LINDOXZENKYESA-UHFFFAOYSA-N TMG Natural products CNC(N)=NC LINDOXZENKYESA-UHFFFAOYSA-N 0.000 claims description 4
- 125000001246 bromo group Chemical group Br* 0.000 claims description 4
- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 claims description 4
- 125000002346 iodo group Chemical group I* 0.000 claims description 4
- SGUVLZREKBPKCE-UHFFFAOYSA-N 1,5-diazabicyclo[4.3.0]-non-5-ene Chemical compound C1CCN=C2CCCN21 SGUVLZREKBPKCE-UHFFFAOYSA-N 0.000 claims description 3
- FVKFHMNJTHKMRX-UHFFFAOYSA-N 3,4,6,7,8,9-hexahydro-2H-pyrimido[1,2-a]pyrimidine Chemical group C1CCN2CCCNC2=N1 FVKFHMNJTHKMRX-UHFFFAOYSA-N 0.000 claims description 3
- KYVBNYUBXIEUFW-UHFFFAOYSA-N 1,1,3,3-tetramethylguanidine Chemical compound CN(C)C(=N)N(C)C KYVBNYUBXIEUFW-UHFFFAOYSA-N 0.000 claims description 2
- -1 isocyanate compounds Chemical class 0.000 description 63
- 150000001875 compounds Chemical class 0.000 description 28
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 24
- 238000000034 method Methods 0.000 description 23
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 19
- 229910052753 mercury Inorganic materials 0.000 description 19
- 238000003756 stirring Methods 0.000 description 15
- 239000000243 solution Substances 0.000 description 14
- 230000015572 biosynthetic process Effects 0.000 description 13
- 150000002009 diols Chemical class 0.000 description 13
- 239000007789 gas Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 238000003786 synthesis reaction Methods 0.000 description 11
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 10
- 229910001882 dioxygen Inorganic materials 0.000 description 10
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 239000012948 isocyanate Substances 0.000 description 9
- 238000005481 NMR spectroscopy Methods 0.000 description 8
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- 125000001072 heteroaryl group Chemical group 0.000 description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 5
- 229920000515 polycarbonate Polymers 0.000 description 5
- 239000004417 polycarbonate Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 125000000923 (C1-C30) alkyl group Chemical group 0.000 description 4
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 4
- 238000004293 19F NMR spectroscopy Methods 0.000 description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 description 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 4
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- DIKBFYAXUHHXCS-UHFFFAOYSA-N bromoform Chemical compound BrC(Br)Br DIKBFYAXUHHXCS-UHFFFAOYSA-N 0.000 description 4
- 229910002091 carbon monoxide Inorganic materials 0.000 description 4
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 4
- 150000008282 halocarbons Chemical class 0.000 description 4
- 125000002950 monocyclic group Chemical group 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 125000000962 organic group Chemical group 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- JZKWRGMHEXSNDT-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-yl carbonochloridate Chemical compound FC(F)(F)C(C(F)(F)F)OC(Cl)=O JZKWRGMHEXSNDT-UHFFFAOYSA-N 0.000 description 3
- XBNGYFFABRKICK-UHFFFAOYSA-N 2,3,4,5,6-pentafluorophenol Chemical compound OC1=C(F)C(F)=C(F)C(F)=C1F XBNGYFFABRKICK-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 description 3
- 125000000304 alkynyl group Chemical group 0.000 description 3
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical class FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- 239000012074 organic phase Substances 0.000 description 3
- IZUPBVBPLAPZRR-UHFFFAOYSA-N pentachloro-phenol Natural products OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl IZUPBVBPLAPZRR-UHFFFAOYSA-N 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- YVXFWWIKAWXLHZ-UHFFFAOYSA-N 1,1,2,2,3-pentafluorodecan-1-ol Chemical compound CCCCCCCC(F)C(F)(F)C(O)(F)F YVXFWWIKAWXLHZ-UHFFFAOYSA-N 0.000 description 2
- LFNVRNWBMJBTKZ-UHFFFAOYSA-N 1-fluorohexan-1-ol Chemical compound CCCCCC(O)F LFNVRNWBMJBTKZ-UHFFFAOYSA-N 0.000 description 2
- UJZBSAONPRVEIJ-UHFFFAOYSA-N 2,2,2-trifluoroethyl carbonochloridate Chemical compound FC(F)(F)COC(Cl)=O UJZBSAONPRVEIJ-UHFFFAOYSA-N 0.000 description 2
- RBZWLYFELFNTOQ-UHFFFAOYSA-N 2,2,2-trifluoroethyl n-cyclohexylcarbamate Chemical compound FC(F)(F)COC(=O)NC1CCCCC1 RBZWLYFELFNTOQ-UHFFFAOYSA-N 0.000 description 2
- PSQZJKGXDGNDFP-UHFFFAOYSA-N 2,2,3,3,3-pentafluoropropan-1-ol Chemical compound OCC(F)(F)C(F)(F)F PSQZJKGXDGNDFP-UHFFFAOYSA-N 0.000 description 2
- NBUKAOOFKZFCGD-UHFFFAOYSA-N 2,2,3,3-tetrafluoropropan-1-ol Chemical compound OCC(F)(F)C(F)F NBUKAOOFKZFCGD-UHFFFAOYSA-N 0.000 description 2
- JYYNAJVZFGKDEQ-UHFFFAOYSA-N 2,4-Dimethylpyridine Chemical compound CC1=CC=NC(C)=C1 JYYNAJVZFGKDEQ-UHFFFAOYSA-N 0.000 description 2
- LCQVAWASRWUKQW-UHFFFAOYSA-N 3,4,5-trifluorobenzene-1,2-diol Chemical compound OC1=CC(F)=C(F)C(F)=C1O LCQVAWASRWUKQW-UHFFFAOYSA-N 0.000 description 2
- HWWYDZCSSYKIAD-UHFFFAOYSA-N 3,5-dimethylpyridine Chemical compound CC1=CN=CC(C)=C1 HWWYDZCSSYKIAD-UHFFFAOYSA-N 0.000 description 2
- VODNNDNUKSKKMP-UHFFFAOYSA-N 4,4,4-trifluorobutane-1,1-diol Chemical compound OC(O)CCC(F)(F)F VODNNDNUKSKKMP-UHFFFAOYSA-N 0.000 description 2
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N 4-methylpyridine Chemical compound CC1=CC=NC=C1 FKNQCJSGGFJEIZ-UHFFFAOYSA-N 0.000 description 2
- ZYUNYSHLBZZGOH-UHFFFAOYSA-N 6,6,6-trifluorohexane-1,1,1-triol Chemical compound C(CCC(F)(F)F)CC(O)(O)O ZYUNYSHLBZZGOH-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000000739 C2-C30 alkenyl group Chemical group 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 2
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- UCYIKXVPERYUJJ-UHFFFAOYSA-N bis(1,1,1,3,3,3-hexafluoropropan-2-yl) carbonate Chemical compound FC(F)(F)C(C(F)(F)F)OC(=O)OC(C(F)(F)F)C(F)(F)F UCYIKXVPERYUJJ-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229950005228 bromoform Drugs 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical class BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- FJBFPHVGVWTDIP-UHFFFAOYSA-N dibromomethane Chemical compound BrCBr FJBFPHVGVWTDIP-UHFFFAOYSA-N 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 231100000086 high toxicity Toxicity 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical class IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- ZWRUINPWMLAQRD-UHFFFAOYSA-N nonan-1-ol Chemical compound CCCCCCCCCO ZWRUINPWMLAQRD-UHFFFAOYSA-N 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000003367 polycyclic group Chemical group 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- CMMNKNZKXHMSEM-UHFFFAOYSA-N (1,2,2,2-tetrafluoro-1-phenoxyethyl) hypofluorite Chemical compound FOC(F)(C(F)(F)F)OC1=CC=CC=C1 CMMNKNZKXHMSEM-UHFFFAOYSA-N 0.000 description 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 description 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 description 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 description 1
- WCFUQBKWMVPFHY-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9-heptadecafluorodecan-1-ol Chemical compound CC(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(O)(F)F WCFUQBKWMVPFHY-UHFFFAOYSA-N 0.000 description 1
- BGYSZBRWPXUSCY-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9-heptadecafluorononan-1-ol Chemical compound OC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CF BGYSZBRWPXUSCY-UHFFFAOYSA-N 0.000 description 1
- NUIRQXBBXRGDHR-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluorodecan-1-ol Chemical compound CCC(C(C(C(C(C(C(C(O)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F NUIRQXBBXRGDHR-UHFFFAOYSA-N 0.000 description 1
- AODWWPFTUICRBK-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluorodecane-1,10-diol Chemical compound OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(O)(F)F AODWWPFTUICRBK-UHFFFAOYSA-N 0.000 description 1
- GUAMVMSOIYAUSK-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluorononan-1-ol Chemical compound CC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(O)(F)F GUAMVMSOIYAUSK-UHFFFAOYSA-N 0.000 description 1
- FGJKPGWSCQCUDW-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8-pentadecafluorononan-1-ol Chemical compound FC(C(C(C(C(C(C(C(O)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)C FGJKPGWSCQCUDW-UHFFFAOYSA-N 0.000 description 1
- GARFAEDATOTMCZ-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8-pentadecafluorooctan-1-ol Chemical compound OC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CF GARFAEDATOTMCZ-UHFFFAOYSA-N 0.000 description 1
- KUGBQWBWWNPMIT-UHFFFAOYSA-N 1,1,2,2,3,3,4,4-octafluoropentan-1-ol Chemical compound CC(F)(F)C(F)(F)C(F)(F)C(O)(F)F KUGBQWBWWNPMIT-UHFFFAOYSA-N 0.000 description 1
- HPFWZNWHCWZFBD-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluorobutan-1-ol Chemical compound OC(F)(F)C(F)(F)C(F)(F)CF HPFWZNWHCWZFBD-UHFFFAOYSA-N 0.000 description 1
- BDMYDBMDPODNHW-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluorodecan-1-ol Chemical compound CCCCCCC(F)C(F)(F)C(F)(F)C(O)(F)F BDMYDBMDPODNHW-UHFFFAOYSA-N 0.000 description 1
- CPEUCWSILZMGQS-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluoroheptan-1-ol Chemical compound CCCC(F)C(F)(F)C(F)(F)C(O)(F)F CPEUCWSILZMGQS-UHFFFAOYSA-N 0.000 description 1
- IZWHEGDRKYSJPZ-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluorohexan-1-ol Chemical compound CCC(F)C(F)(F)C(F)(F)C(O)(F)F IZWHEGDRKYSJPZ-UHFFFAOYSA-N 0.000 description 1
- GANYAUZQJONIMH-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluorononan-1-ol Chemical compound CCCCCC(C(C(C(O)(F)F)(F)F)(F)F)F GANYAUZQJONIMH-UHFFFAOYSA-N 0.000 description 1
- BXHLFNLUMVTMKQ-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluorooctan-1-ol Chemical compound CCCCC(F)C(F)(F)C(F)(F)C(O)(F)F BXHLFNLUMVTMKQ-UHFFFAOYSA-N 0.000 description 1
- YIHRGKXNJGKSOT-UHFFFAOYSA-N 1,1,2,2,3,3-hexafluorobutan-1-ol Chemical compound CC(F)(F)C(F)(F)C(O)(F)F YIHRGKXNJGKSOT-UHFFFAOYSA-N 0.000 description 1
- AOEUTHHFYBIAEB-UHFFFAOYSA-N 1,1,2,2,3,3-hexafluorodecan-1-ol Chemical compound CCCCCCCC(C(C(O)(F)F)(F)F)(F)F AOEUTHHFYBIAEB-UHFFFAOYSA-N 0.000 description 1
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- 125000005981 pentynyl group Chemical group 0.000 description 1
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 description 1
- 125000001828 phenalenyl group Chemical group C1(C=CC2=CC=CC3=CC=CC1=C23)* 0.000 description 1
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000001725 pyrenyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001935 tetracenyl group Chemical group C1(=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C12)* 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- ABVVEAHYODGCLZ-UHFFFAOYSA-N tridecan-1-amine Chemical compound CCCCCCCCCCCCCN ABVVEAHYODGCLZ-UHFFFAOYSA-N 0.000 description 1
- SWZDQOUHBYYPJD-UHFFFAOYSA-N tridodecylamine Chemical compound CCCCCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC SWZDQOUHBYYPJD-UHFFFAOYSA-N 0.000 description 1
- RKBCYCFRFCNLTO-UHFFFAOYSA-N triisopropylamine Chemical compound CC(C)N(C(C)C)C(C)C RKBCYCFRFCNLTO-UHFFFAOYSA-N 0.000 description 1
- ODHXBMXNKOYIBV-UHFFFAOYSA-N triphenylamine Chemical compound C1=CC=CC=C1N(C=1C=CC=CC=1)C1=CC=CC=C1 ODHXBMXNKOYIBV-UHFFFAOYSA-N 0.000 description 1
- 125000003960 triphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C3=CC=CC=C3C12)* 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
また、本発明者は、ハロゲン化炭化水素とアルコールとを含む混合物に、酸素存在下で光照射することを特徴とするハロゲン化カルボン酸エステルの製造方法を開発している(特許文献3)。
また、特許文献3に記載の方法では、ハロゲン化炭化水素に対して比較的少量のアルコールを用いることにより、カーボネートの生成を抑制してハロゲン化ギ酸エステルを得ている。しかし特許文献3に記載の方法では、脱離し易く求核性が低いハロゲン化アルコキシル基を有するハロゲノギ酸ハロゲン化アルキルエステルを得ることができない。
そこで本発明は、カルバメートやイソシアネート化合物の合成中間体にもなるハロゲノギ酸ハロゲン化アルキルエステルを安全かつ効率的に製造できる方法を提供することを目的とする。
以下、本発明を示す。
更にハロゲン化アルコールを添加し、上記高エネルギー光を照射せずに反応させる工程を含むことを特徴とするハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[2] 上記温度が5℃以下である上記[1]に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[3] 上記ハロゲン化アルコールに加えて、塩基を添加する上記[1]または[2]に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[4] 上記塩基が複素環式芳香族アミンおよび非求核性強塩基から選択される1以上である上記[3]に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[5] 上記複素環式芳香族アミンが、ピリジン、ピコリンまたはルチジンである上記[4]に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[6] 上記非求核性強塩基が、1,5,7-トリアザビシクロ[4.4.0]デカ-5-エン、7-メチル-1,5,7-トリアザビシクロ[4.4.0]デカ-5-エン、1,8-ジアザビシクロ[5.4.0]ウンデカ-7-エン、1,5-ジアザビシクロ[4.3.0]ノナ-5-エンまたは1,1,3,3-テトラメチルグアニジンである上記[4]に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[7] 上記高エネルギー光が180nm以上、280nm以下の波長の光を含むものである上記[1]~[6]のいずれかに記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[8] 上記ハロゲン化メタンにおけるハロゲノ基が、クロロ、ブロモおよびヨードから選択される1以上である上記[1]~[7]のいずれかに記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
[9] 上記ハロゲン化メタンがクロロホルムである上記[1]~[8]のいずれかに記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
本工程では、ハロゲン化メタンに、酸素存在下、15℃以下の温度で高エネルギー光を照射することにより、ハロゲン化メタンを分解してハロゲン化カルボニルまたはハロゲン化カルボニル様化合物を得る。
本発明の別の態様では、高エネルギー光を照射したハロゲン化メタンに、更にハロゲン化アルコールを添加し、高エネルギー光を照射せずに反応させることにより、ハロゲノギ酸ハロゲン化アルキルエステルを得る。ハロゲン化アルコールが式R1-(OH)nで表される化合物である場合の反応式を以下に示す。
その他、トリメチルアミン、ジメチルエチルアミン、ジエチルメチルアミン、N-エチル-N-メチルブチルアミン、1-メチルピロリジン等の汎用有機アミンも用い得る。
直径42mm、容量100mLの筒状反応容器内に、直径30mmの石英ガラスジャケットを装入し、更に石英ガラスジャケット内に低圧水銀ランプ(「UVL20PH-6」SEN Light社製,20W,φ24×120mm)を装入した反応システムを構築した。当該反応システムの模式図を図1に示す。なお、当該低圧水銀ランプからの照射光には波長254nmのUV-Cが含まれ、管壁から5mmの位置における波長254nmの光の照度は6.23~9.07mW/cm2であった。反応容器内に精製したクロロホルム(20mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、上記低圧水銀ランプを使ってUV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、ヘキサフルオロ-2-プロパノール(0.52mL,5mmol)とピリジン(1.2mL,15mmol)を0℃で添加し、30℃で1時間攪拌した。
反応液を1H NMRで分析したところ、目的化合物であるクロロギ酸ヘキサフルオロイソプロピルエステルが収率92%で生成していることが確認された。その他、炭酸ジ(ヘキサフルオロイソプロピル)が収率4%で生成しており、4%のヘキサフルオロ-2-プロパノールが残留していた。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、ペンタフルオロフェノール(1.84g,10mmol)のクロロホルム溶液(4mL)とピリジン(3.18mL,30mmol)を添加し、0℃で1時間攪拌した。
反応液を1H NMRで分析したところ、目的化合物であるクロロギ酸ペンタフルオロフェノールエステルが収率77%で生成していることが確認された。その他、炭酸ジ(ペンタフルオロフェノール)が収率20%で生成していた。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、2,2,2-トリフルオロエタノール(0.71mL,10mmol)とピリジン(3.18mL,30mmol)を添加し、-30℃で2時間攪拌した。
反応液を1H NMRで分析したところ、目的化合物であるクロロギ酸2,2,2-トリフルオロエチルエステルが収率71%で生成していることが確認された。その他、炭酸ジ(2,2,2-トリフルオロエチル)が収率2%で生成していた。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、ペンタフルオロフェノール(1.84g,10mmol)とピリジン(3.18mL,30mmol)を添加し、0℃で1時間攪拌した。
更に、シクロヘキシルアミン(1.15mL,10mmol)とピリジン(1.06mL,10mmol)を添加し、室温で1時間攪拌した。
反応液に1M塩酸を加えて分液し、目的化合物であるパーフルオロフェニル シクロヘキシルカルバメートを有機相から蒸留した(収量:0.57g,収率:18%)。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、2,2,2-トリフルオロエタノール(0.71mL,10mmol)とピリジン(3.18mL,30mmol)を添加し、0℃で2時間攪拌した。
更に、シクロヘキシルアミン(2.30mL,20mmol)を添加し、室温で1時間攪拌した。
反応液に1M塩酸を加えて分液し、有機相を減圧濃縮することにより、目的化合物である2,2,2-トリフルオロエチル シクロヘキシルカルバメートを得た(収量:0.37g,収率:16%)。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ0.5L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、2,2,3,3,4,4,5,5-オクタフルオロ-1,6-ヘキサンジオール(1.31g,5mmol)とピリジン(3.18mL,30mmol)を混合した溶液添加し、-30℃で2時間攪拌した。反応液を1H NMRで分析したところ、クロロギ酸エステル(2,2,3,3,4,4,5,5-オクタフルオロヘキサメチレン 1,6-ビス(カーボネート))が収率68%で生成していることが確認された。その他、ポリカーボネートが収率29%で生成していた。
1H NMR(400MHz,CDCl3)δ(ppm):4.77(t,J=12Hz,4H,-CH2-)
19F NMR(376MHz,CDCl3)δ(ppm):-119.68(m,4F),-123.43(m,4F)
更に、50℃で2時間攪拌した後、シクロヘキサノール(1.04mL,10mmol)を添加し、室温で終夜攪拌した。
反応液に1M塩酸を加えて分液し、クーゲルロールで蒸留することによって、目的化合物であるジシクロヘキシル (2,2,3,3,4,4,5,5-オクタフルオロヘキサメチレン) 1,6-ビス(カーボネート)を単離した(収量:1.58g,収率:62%)。
1H NMR(400MHz,CDCl3)δ(ppm):1.21-1.58(m,12H,cyclohexyl),1.77(m,4H,cyclohexyl),1.94(m,4H,cyclohexyl),4.61(t,J=14Hz,4H,-CH2-),4.66(m,2H,-CH-)
19F NMR(376MHz,CDCl3)δ(ppm):-120.18(m,4F),-123.73(m,4F)
FAB-MS m/z calcd:514.41,found:514.68 [M]+
IR(ATR)cm-1:2941,2864,1754,1453,1405,1275,1256,1173,1123,1035,1009,944,893,871,786
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ0.5L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-ヘキサデカフルオロ-1,10-デカンジオール(2.31g,5mmol)とピリジン(3.18mL,30mmol)を混合した溶液添加し、-30℃で2時間攪拌した。反応液を1H NMRで分析したところ、クロロギ酸エステル(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-ヘキサデカフルオロデカメチレン 1,10-ビス(カーボネート))が収率89%で生成していることが確認された。その他、ポリカーボネートが収率11%で生成していた。
1H NMR(400MHz,CDCl3)δ(ppm):4.77(t,J=13Hz,4H,-CH2-)
19F NMR(376MHz,CDCl3)δ(ppm):-119.55(m,4F),-121.80(m,8F),-123.17(m,4F)
更に、50℃で2時間攪拌した後、シクロヘキサノール(1.04mL,10mmol)を添加し、室温で終夜攪拌した。
反応液に1M塩酸を加えて分液し、クーゲルロールで蒸留することによって、目的化合物であるジシクロヘキシル (2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-ヘキサデカフルオロデカメチレン) 1,10-ビス(カーボネート)を単離した(収量:1.17g,収率:33%)。
1H NMR(400MHz,CDCl3)δ(ppm):1.21-1.58(m,12H,cyclohexyl),1.77(m,4H,cyclohexyl),1.93(m,4H,cyclohexyl),4.62(t,J=13Hz,4H,-CH2-),4.68(m,2H,-CH-)
19F NMR(376MHz,CDCl3)δ(ppm):-119.97(m,4F),-121.86(m,8F),-123.38(m,4F)
FAB-MS m/z calcd:714.15,found:714.29 [M]+
IR(ATR)cm-1:2941,2865,1757,1455,1405,1276,1258,1205,1146,1036,1010,938,786
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、クロロホルム(3mL)に溶解させたヘキサフルオロ-2-プロパノール(1.04mL,10mmol)を添加し、続いてクロロホルム(3mL)に溶解させたピリジン(3.18mL,30mmol)を添加し、-30℃で2時間攪拌した。反応液を1H NMRで分析したところ、クロロギ酸ヘキサフルオロイソプロピルエステルが収率78%で生成していることが確認された。その他、炭酸ジ(ヘキサフルオロイソプロピル)が収率20%で生成していた。
続いて、反応液にベンジルアミン(1.09mL,10mmol)とピリジン(1.06mL,10mmol)を添加し、室温で1日攪拌した。反応液に1M塩酸を加えて分液し、有機相を減圧濃縮することにより、目的化合物であるヘキサフルオロイソプロピル ベンジルカルバメートを得た(収量:1.06g,収率:35%)。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、クロロホルム(3mL)に溶解させた2,2,3,3-テトラフルオロ-1-プロパノール(1.32g,10mmol)を添加し、続いてクロロホルム(3mL)に溶解させたピリジン(3.18mL,30mmol)を添加し、-30℃で2時間攪拌した。
反応液を1H NMRで分析したところ、2,2,3,3-テトラフルオロプロピルクロロギ酸エステルが収率99%以上で生成していることが確認された。
実施例1で用いた反応システムの反応容器内に精製したクロロホルム(50mL)を入れ、0℃で攪拌しつつ1.0L/minの酸素ガスをバブリングで吹き込み、UV-Cを含む光を照射した。
3時間後、低圧水銀ランプの電源を切り、通常の室内灯下、クロロホルム(3mL)に溶解させた2,2,3,3,3-ペンタフルオロ-1-プロパノール(1.50g,10mmol)を添加し、続いてクロロホルム(3mL)に溶解させたピリジン(3.18mL,30mmol)を添加し、-30℃で2時間攪拌した。
反応液を1H NMRで分析したところ、2,2,3,3,3-ペンタフルオロプロピルクロロギ酸エステルが収率80%で生成していることが確認された。
4: 撹拌子, 5: 熱媒または冷媒, 6: 筒状反応容器
Claims (7)
- ハロゲン化メタンに、酸素存在下、15℃以下の温度で高エネルギー光を照射する工程、および、
更にハロゲン化アルコールと、複素環式芳香族アミンおよび非求核性強塩基から選択される1以上の塩基を添加し、上記高エネルギー光を照射せずに反応させる工程を含むことを特徴とするハロゲノギ酸ハロゲン化アルキルエステルの製造方法。 - 上記温度が5℃以下である請求項1に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
- 上記複素環式芳香族アミンが、ピリジン、ピコリンまたはルチジンである請求項1に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
- 上記非求核性強塩基が、1,5,7-トリアザビシクロ[4.4.0]デカ-5-エン、7-メチル-1,5,7-トリアザビシクロ[4.4.0]デカ-5-エン、1,8-ジアザビシクロ[5.4.0]ウンデカ-7-エン、1,5-ジアザビシクロ[4.3.0]ノナ-5-エンまたは1,1,3,3-テトラメチルグアニジンである請求項1に記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
- 上記高エネルギー光が180nm以上、280nm以下の波長の光を含むものである請求項1~4のいずれかに記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
- 上記ハロゲン化メタンにおけるハロゲノ基が、クロロ、ブロモおよびヨードから選択される1以上である請求項1~5のいずれかに記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
- 上記ハロゲン化メタンがクロロホルムである請求項1~6のいずれかに記載のハロゲノギ酸ハロゲン化アルキルエステルの製造方法。
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JP2012067030A (ja) | 2010-09-22 | 2012-04-05 | Mitsui Chemicals Agro Inc | クロロギ酸含フッ素アルキルの改良された製造方法 |
JP2013181028A (ja) | 2012-03-05 | 2013-09-12 | Kobe Univ | ハロゲン化炭化水素に光照射して得られる混合物の使用 |
WO2015156245A1 (ja) | 2014-04-09 | 2015-10-15 | 国立大学法人神戸大学 | ハロゲン化カルボン酸エステルの製造方法 |
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JP2013181028A (ja) | 2012-03-05 | 2013-09-12 | Kobe Univ | ハロゲン化炭化水素に光照射して得られる混合物の使用 |
WO2015156245A1 (ja) | 2014-04-09 | 2015-10-15 | 国立大学法人神戸大学 | ハロゲン化カルボン酸エステルの製造方法 |
Non-Patent Citations (5)
Title |
---|
ALAPI, T. et al.,Direct VUV photolysis of chlorinated methanes and their mixtures in an oxygen stream using an ozone,Chemosphere,2007年,Vol.67,pp.693-701 |
HAUTECLOQUE,S.,On the photooxidation of gaseous HCCl3 and ClO radical formation,Journal of Photochemisty,1980年,Vol.14,pp.157-165 |
W. Sean McGivern, et al.,Investigation of the Atmospheric Oxidation Pathways of Bromoform and Dibromomethane:Initiation via U,J. Phys. Chem. A,2004年,Vol.108,pp.7247-7252 |
入江喜一,ホスゲンの製造と利用,燃料協会誌,1960年,Vol.39,No.400,pp.575-583 |
河合聰,クロロホルムの分解に関する考察,薬学雑誌,1966年,Vol.86,No.12,pp.1125-1132 |
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