JP7412001B2 - 改変されたＣａｓ９タンパク質及びその用途 - Google Patents
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008008523A1 (en) | 2006-07-14 | 2008-01-17 | Regents Of The University Of Minnesota | COMPOUNDS THAT BIND α5β1 INTEGRIN AND METHODS OF USE |
| JP2010505437A (ja) | 2006-10-13 | 2010-02-25 | ノボ ノルディスク ヘルス ケア アーゲー | 塩基性タンパク質タグに融合したプロセシング酵素 |
| JP2016533332A (ja) | 2013-09-24 | 2016-10-27 | マサチューセッツ インスティテュート オブ テクノロジー | 自己集合型ナノ粒子ワクチン |
| WO2016196655A1 (en) | 2015-06-03 | 2016-12-08 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
| WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
| JP2017527284A (ja) | 2014-09-01 | 2017-09-21 | ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ | 変異体ポア |
| WO2017217768A1 (ko) | 2016-06-15 | 2017-12-21 | 주식회사 툴젠 | 온타겟 및 오프타겟의 다중 타겟 시스템을 이용하는, 표적 특이적 유전자 가위 스크리닝 방법 및 이의 용도 |
| JP2018502572A5 (de) | 2015-12-31 | 2019-02-14 |
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| EP3265559B1 (de) | 2015-03-03 | 2021-01-06 | The General Hospital Corporation | Manipulierte crispr-cas9-nukleasen mit veränderter pam-spezifität |
| JP7107683B2 (ja) * | 2015-06-18 | 2022-07-27 | ザ・ブロード・インスティテュート・インコーポレイテッド | オフターゲット効果を低下させるｃｒｉｓｐｒ酵素突然変異 |
| JPWO2017010543A1 (ja) | 2015-07-14 | 2018-06-14 | 国立大学法人 東京大学 | 改変されたＦｎＣａｓ９タンパク質及びその使用 |
| SG10201913505WA (en) | 2016-10-17 | 2020-02-27 | Univ Nanyang Tech | Truncated crispr-cas proteins for dna targeting |
| CN110662835B (zh) | 2017-05-19 | 2023-04-28 | 清华大学 | 工程化改造用于由增强的指导RNA优化的基因编辑和转录调节的最小化SaCas9 CRISPR/Cas系统 |
| WO2019089910A1 (en) * | 2017-11-01 | 2019-05-09 | Ohio State Innovation Foundation | Highly compact cas9-based transcriptional regulators for in vivo gene regulation |
| BR112021009481A2 (pt) * | 2018-11-16 | 2021-08-17 | Astellas Pharma Inc. | método para tratamento da distrofia muscular direcionando gene de utrofina. |
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| CN112513266A (zh) | 2021-03-16 |
| CA3103088A1 (en) | 2019-12-12 |
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| WO2019235627A1 (ja) | 2019-12-12 |
| US20220017881A1 (en) | 2022-01-20 |
| MX2020013158A (es) | 2021-04-29 |
| BR112020024992A2 (pt) | 2021-03-23 |
| EP3805386A4 (de) | 2022-03-23 |
| JPWO2019235627A1 (ja) | 2021-06-24 |
| EP3805386A1 (de) | 2021-04-14 |
| AU2019281158A1 (en) | 2021-01-14 |
| ZA202100092B (en) | 2021-10-27 |
| SG11202012228QA (en) | 2021-01-28 |
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