JP7404259B2 - 単独使用のための充電式バッテリを含むnfc血糖値測定器 - Google Patents
単独使用のための充電式バッテリを含むnfc血糖値測定器 Download PDFInfo
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- 125000001424 substituent group Chemical group 0.000 description 1
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- 108010048573 taspoglutide Proteins 0.000 description 1
- WRGVLTAWMNZWGT-VQSPYGJZSA-N taspoglutide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 WRGVLTAWMNZWGT-VQSPYGJZSA-N 0.000 description 1
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- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 229940026454 tresiba Drugs 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
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- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
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Description
・生理学的パラメータの値、たとえば血糖レベルを測定するように適用されている測定ユニットと、
・測定ユニットにエネルギー供給を行う、測定ユニットと連結されているエネルギー貯蔵ユニットと、
・内部NFCアンテナと、
・NFCアンテナとおよびエネルギー貯蔵ユニットと連結されているエネルギー供給ユニットであって、所定の周波数範囲の電磁場が存在する際、NFCアンテナの周囲の電磁場からエネルギーが引き出されエネルギー貯蔵ユニットに貯蔵されるようにNFCアンテナを制御する、エネルギー供給ユニットと、
・エネルギー貯蔵ユニットに連結されエネルギー貯蔵ユニットに含まれている電荷を判定するように適用されている充電制御ユニットと、
・充電制御ユニットと連結されている通信ユニットであって、充電制御ユニットによって判定されたエネルギー貯蔵ユニットに含まれている電荷が所定の最小電荷値以下である場合に、所定の視覚的、聴覚的、および/または触覚的な信号を出力するように適用されている、通信ユニットと、を含む。
- エネルギー貯蔵ユニットと連結されている、追加のエネルギー供給のための太陽電池、この太陽電池はPCBに組み込むことができる、
- 測定ユニットは組み込まれたA1c推定アルゴリズムを提供できる、
- デバイスは、MRSA対応洗浄剤で洗浄できるように封止することができる。
- デバイスは温度を連続的にチェックする組み込まれた温度追跡器を含んでもよく、この場合、最小温度値以下の温度または最大温度値以上の温度(最大温度値は最小温度値よりも大きい)では、誤った測定値を回避するために、使用者が生理学的パラメータの測定を行うことが阻止される、
- デバイスは、モバイルデバイスから独立して機能するために、NFCインスリン管理デバイスへのインターフェースを含むことができる、
- デバイスはBGMデータの管理を行うことができる、
- デバイスは、測定されたまたは記憶されているBGMデータ、ならびにBGMターゲットデータを、表示することができる、
- デバイスのインターフェースは、アプリ、クラウド、HCPデータベースへの接続、ならびにこのデータベースへのアクセスを提供することができる。
・測定ユニットによって生理学的パラメータの1回の測定が行われる前に、エネルギー貯蔵ユニットに含まれている電荷を判定する工程、
・充電制御ユニットによって判定されたエネルギー貯蔵ユニットに含まれている電荷が所定の最小電荷値よりも大きい場合に、測定ユニットを使用して生理学的パラメータを測定する工程、または
・充電制御ユニットによって判定されたエネルギー貯蔵ユニットに含まれている電荷が所定の最小電荷値以下である場合に、通信ユニットによって所定の視覚的、聴覚的、および/もしくは触覚的な信号を出力する工程、を含む、方法、に言及する。
110 血糖測定ユニット
112 スロット
130 データストレージ
150 使用者入力ユニット
151、153 キー
154 キー
152 確定キー
160 ディスプレイユニット
162 ディスプレイ
170 インターフェース
180 クロックユニット
190 エネルギー貯蔵ユニット
193 NFCアンテナ(内部)
195 エネルギー供給ユニット
196、196A 充電制御ユニット
197 電子回路を有するPCB
198 コイル
199 フェライトコア
200 外部NFCアンテナ
202 抵抗器
204 電圧計
206 プロセッサ
310、320 医療デバイスの動作方法の工程
330、340 医療デバイスの動作方法の工程
350、360 医療デバイスの動作方法の工程
370、380 医療デバイスの動作方法の工程
390、400 医療デバイスの動作方法の工程
410 医療デバイスの動作方法の工程
Claims (11)
- 医療デバイス(100)であって、
生理学的パラメータの値を測定するように適用されている測定ユニット(110)と、
該測定ユニット(110)にエネルギー供給を行う、該測定ユニット(110)と連結されているエネルギー貯蔵ユニット(190)と、
フェライトコア(199)またはディスクを含む、NFCアンテナ(193)と、
該NFCアンテナ(193)およびエネルギー貯蔵ユニット(190)に連結されているエネルギー供給ユニット(195)であって、所定の周波数範囲の電磁場が存在する際、NFCアンテナ(193)の周囲の電磁場からエネルギーが引き出されエネルギー貯蔵ユニット(190)に貯蔵されるようにNFCアンテナ(193)を制御する、エネルギー供給ユニット(195)と、
エネルギー貯蔵ユニット(190)に連結され、該エネルギー貯蔵ユニット(190)に含まれている電荷を判定するように適用されている充電制御ユニット(196、196A)であって、該充電制御ユニット(196、196A)は、測定ユニット(110)によって生理学的パラメータの1回の測定が行われる前に、エネルギー貯蔵ユニット(190)に含まれている電荷を判定するように適用されている、充電制御ユニット(196、196A)と、
該充電制御ユニット(196、196A)と連結されている通信ユニット(160)であって、該充電制御ユニット(196、196A)によって判定されたエネルギー貯蔵ユニット(190)に含まれている電荷が所定の最小電荷値以下である場合に、所定の視覚的、聴覚的、および/または触覚的な信号を出力するように適用されている、通信ユニット(160)と、
を含み、
該測定ユニットは、該充電制御ユニットによって判定されたエネルギー貯蔵ユニットに含まれている電荷が所定の最小電荷値以下である場合に、該測定ユニットによる生理学的パラメータの値の判定をブロックするように適用される、
前記医療デバイス。 - 生理学的パラメータは血糖レベルである、請求項1に記載の医療デバイス。
- 充電制御ユニットはガスゲージ(196)を含む、請求項1または2に記載の医療デバイス。
- NFCアンテナ(193)は、PCB(197)上にプリントされた構造によって形成されている、請求項1~3のいずれか1項に記載の医療デバイス。
- 充電制御ユニット(196、196A)はエネルギー供給ユニット(195)に連結されており、該充電制御ユニット(196、196A)は、該充電制御ユニット(196、196A)によって判定されたエネルギー貯蔵ユニット(190)に含まれている電荷が所定の最小電荷値以下である場合に、エネルギー供給ユニットを起動しNFCアンテナを使用してエネルギーを引き出す、請求項1~4のいずれか1項に記載の医療デバイス。
- スリープ状態において、充電制御ユニット(196、196A)は、該充電制御ユニット(196、196A)によって判定されたエネルギー貯蔵ユニット(190)に含まれている電荷が所定の最小電荷値以下である場合に、エネルギー供給ユニット(195)を起動しNFCアンテナを使用してエネルギーを引き出す、請求項5に記載の医療デバイス。
- デバイスは測定された値または生理学的パラメータの値に基づいて薬剤を投与するように適用されている、請求項1~6のいずれか1項に記載の医療デバイス。
- 医療デバイスは、温度を連続的にチェックする組み込まれた温度追跡器を含み、この場合、最小温度値以下の温度または最大温度値以上の温度では、誤った測定値を回避するために、使用者が生理学的パラメータの測定を行うことが阻止される、請求項1~7のいずれか1項に記載の医療デバイス。
- 所定の最小電荷値は30mAである、請求項1~8のいずれか1項に記載の医療デバイス。
- 請求項1~9のいずれか1項に記載の医療デバイスの作動方法であって、
測定ユニット(110)によって生理学的パラメータの1回の測定が行われる前に、エネルギー貯蔵ユニット(190)に含まれている電荷を判定する工程、
充電制御ユニット(196、196A)によって判定されたエネルギー貯蔵ユニット(190)に含まれている電荷が所定の最小電荷値よりも大きい場合に、測定ユニットを使用して生理学的パラメータを測定する工程、または
充電制御ユニット(196、196A)によって判定されたエネルギー貯蔵ユニット(190)に含まれている電荷が所定の最小電荷値以下である場合に、通信ユニット(160)によって所定の視覚的、聴覚的、および/もしくは触覚的な信号を出力する工程、を含む、前記方法。 - 充電制御ユニット(196、196A)によって判定されたエネルギー貯蔵ユニット(190)に含まれている電荷が所定の最小電荷値以下である場合に、エネルギー供給ユニット(195)を起動しNFCアンテナ(193)を使用してエネルギーを引き出す工程を含む、請求項10に記載の方法。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013135557A (ja) | 2011-12-27 | 2013-07-08 | Fujifilm Corp | 医療機器の非接触給電システムおよび方法 |
JP2017505648A (ja) | 2013-12-30 | 2017-02-23 | ヴェリリー ライフ サイエンシズ エルエルシー | 条件検索 |
US20170055890A1 (en) | 2015-09-02 | 2017-03-02 | Roche Diabetes Care, Inc. | Sensor module and kit for determining an analyte concentration |
JP2017196423A (ja) | 2006-09-28 | 2017-11-02 | 株式会社半導体エネルギー研究所 | 無線センシング装置 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7399277B2 (en) | 2001-12-27 | 2008-07-15 | Medtronic Minimed, Inc. | System for monitoring physiological characteristics |
US20060001551A1 (en) * | 2004-06-30 | 2006-01-05 | Ulrich Kraft | Analyte monitoring system with wireless alarm |
CN2728513Y (zh) | 2004-09-27 | 2005-09-28 | 陈永曦 | 留置针保护套与留置针组合体 |
US7620438B2 (en) * | 2006-03-31 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
US7879026B2 (en) | 2007-09-07 | 2011-02-01 | Asante Solutions, Inc. | Controlled adjustment of medicine dispensation from an infusion pump device |
CN101896116B (zh) * | 2007-12-10 | 2014-06-18 | 拜尔健康护理有限责任公司 | 用电池供电的液体分析仪的快速充电和电源管理 |
JP5430555B2 (ja) * | 2008-03-27 | 2014-03-05 | パナソニック株式会社 | 環境温度測定方法、液体試料測定方法およびバイオセンサ用測定器 |
JP5711155B2 (ja) | 2009-02-27 | 2015-04-30 | ライフスキャン・インコーポレイテッドLifescan,Inc. | 薬物送達ペンのための医療モジュール |
US8140294B2 (en) * | 2009-06-05 | 2012-03-20 | Roche Diagnostics Operations, Inc. | Temperature estimations in a blood glucose measuring device |
EP2478337B1 (en) | 2009-09-18 | 2015-08-26 | Sanofi-Aventis Deutschland GmbH | Arrangement for determining a longitudinal position of a stopper |
JP5195852B2 (ja) * | 2010-09-06 | 2013-05-15 | トヨタ自動車株式会社 | 車両用シート |
DK2673020T3 (da) | 2011-02-09 | 2017-11-20 | Sanofi Aventis Deutschland | Pen-injektionsanordning til to lægemidler med mikroreservoirer, der indeholder sekundært lægemiddel til nødinjektion |
FR2981519B1 (fr) * | 2011-10-12 | 2015-04-03 | Continental Automotive France | Dispositif de chargement inductif d'un appareil portable integrant une antenne de communication en champ proche |
AT512101A2 (de) | 2011-10-31 | 2013-05-15 | Seibersdorf Labor Gmbh | Messeinrichtung zur glukosemessung |
AU2012348406B2 (en) | 2011-12-06 | 2015-05-07 | Shl Medical Ag | Medicament delivery device |
WO2013144617A1 (en) * | 2012-03-30 | 2013-10-03 | Lifescan Scotland Limited | Battery status detection and storage method and system in medical monitoring |
US8817258B2 (en) | 2012-05-21 | 2014-08-26 | Common Sensing Inc. | Dose measurement system and method |
US20140172309A1 (en) * | 2012-12-14 | 2014-06-19 | Lifescan Scotland Limited | Context aware blood glucose measurement system |
EP3135195B1 (en) * | 2013-03-12 | 2023-09-20 | Roche Diabetes Care GmbH | Method for transmitting a glucose measure and handheld glucose meter |
KR20140115209A (ko) * | 2013-03-20 | 2014-09-30 | 삼성에스디아이 주식회사 | 안테나를 갖는 배터리 팩 |
EP2781230B1 (de) | 2013-03-22 | 2019-08-21 | TecPharma Licensing AG | Substanzabgabevorrichtung mit Signalvorrichtung |
DK2996743T3 (en) | 2013-05-16 | 2019-04-01 | Sanofi Aventis Deutschland | DEVICE FOR A PHARMACEUTICAL ADMINISTRATION DEVICE AND PHARMACEUTICAL ADMINISTRATION DEVICE |
US9383332B2 (en) * | 2013-09-24 | 2016-07-05 | Lifescan Scotland Limited | Analytical test strip with integrated battery |
WO2015136564A1 (en) | 2014-03-10 | 2015-09-17 | Osvaldo Tufi | Add-on module for monitoring and control of compliance to therapy for injectable drugs contained in pre-filled syringes |
WO2015140597A1 (en) * | 2014-03-19 | 2015-09-24 | Glucome Ltd. | Glucometer and method for use |
TWI559897B (en) * | 2014-03-31 | 2016-12-01 | Bionime Corp | System and method for measuring physiological parameters |
US9689753B2 (en) * | 2014-05-22 | 2017-06-27 | Roche Diabetes Care, Inc. | Handheld analyte meter with recharging control for improved analyte testing |
WO2016019375A1 (en) | 2014-08-01 | 2016-02-04 | Common Sensing Inc. | Liquid measurement systems, apparatus, and methods optimized with temperature sensing |
CN105361865B (zh) * | 2014-08-18 | 2021-06-08 | 三星电子株式会社 | 可穿戴的生物特征信息测量装置 |
EP3204089B1 (en) | 2014-10-06 | 2023-10-04 | Sanofi-Aventis Deutschland GmbH | A drug delivery device with at least one transparent region of housing |
US9197082B1 (en) * | 2014-12-09 | 2015-11-24 | Jack Ke Zhang | Techniques for power source management using a wrist-worn device |
US20160161985A1 (en) * | 2014-12-09 | 2016-06-09 | Jack Ke Zhang | Techniques for power source management using a wrist-worn device |
DK3242699T3 (da) | 2015-01-08 | 2021-06-07 | Novo Nordisk As | Et trådløst datakommunikationsmodul til enheder til injektion af lægemiddel |
KR101594380B1 (ko) * | 2015-03-04 | 2016-02-16 | 엘지전자 주식회사 | 이동 단말기 및 코일 안테나 모듈 |
EP3265151B1 (en) | 2015-03-06 | 2021-11-24 | Sanofi-Aventis Deutschland GmbH | Sensor arrangement for an injection device |
JP6918702B2 (ja) | 2015-04-16 | 2021-08-11 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 充填レベルの容量判定のためのセンサおよびセンサアセンブリ |
EP3573689B1 (en) | 2017-01-26 | 2022-04-06 | Sanofi-Aventis Deutschland GmbH | Flexible modules for injection devices |
US11517224B2 (en) * | 2017-11-21 | 2022-12-06 | Sanofi | Implantable glucose monitor |
-
2018
- 2018-12-17 WO PCT/EP2018/085114 patent/WO2019121450A1/en unknown
- 2018-12-17 EP EP18829793.1A patent/EP3727150B1/en active Active
- 2018-12-17 US US16/954,378 patent/US11744488B2/en active Active
- 2018-12-17 CN CN201880089105.5A patent/CN112041681A/zh active Pending
- 2018-12-17 JP JP2020552132A patent/JP7404259B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017196423A (ja) | 2006-09-28 | 2017-11-02 | 株式会社半導体エネルギー研究所 | 無線センシング装置 |
JP2013135557A (ja) | 2011-12-27 | 2013-07-08 | Fujifilm Corp | 医療機器の非接触給電システムおよび方法 |
JP2017505648A (ja) | 2013-12-30 | 2017-02-23 | ヴェリリー ライフ サイエンシズ エルエルシー | 条件検索 |
US20170055890A1 (en) | 2015-09-02 | 2017-03-02 | Roche Diabetes Care, Inc. | Sensor module and kit for determining an analyte concentration |
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