JP7387590B2 - ラパマイシン誘導体 - Google Patents

ラパマイシン誘導体 Download PDF

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JP7387590B2
JP7387590B2 JP2020516599A JP2020516599A JP7387590B2 JP 7387590 B2 JP7387590 B2 JP 7387590B2 JP 2020516599 A JP2020516599 A JP 2020516599A JP 2020516599 A JP2020516599 A JP 2020516599A JP 7387590 B2 JP7387590 B2 JP 7387590B2
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disease
cancer
disorder
pharmaceutically acceptable
acceptable salt
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JP2020535134A (ja
JP2020535134A5 (OSRAM
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ボナッツィ，シモン
コノリー，マイケル
ジョナサン グラス，デイビッド
ミハリック，マニュエル
ウィリアム パターソン，アンドリュー
ロッゴ，シルビオ
シャフラカージェ，ティー
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
JP2020516599A 2017-09-26 2018-09-25 ラパマイシン誘導体 Active JP7387590B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023081938A JP7699626B2 (ja) 2017-09-26 2023-05-18 ラパマイシン誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762563312P 2017-09-26 2017-09-26
US62/563,312 2017-09-26
PCT/IB2018/057422 WO2019064182A1 (en) 2017-09-26 2018-09-25 RAPAMYCIN DERIVATIVES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023081938A Division JP7699626B2 (ja) 2017-09-26 2023-05-18 ラパマイシン誘導体

Publications (3)

Publication Number Publication Date
JP2020535134A JP2020535134A (ja) 2020-12-03
JP2020535134A5 JP2020535134A5 (OSRAM) 2021-10-14
JP7387590B2 true JP7387590B2 (ja) 2023-11-28

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JP2020516599A Active JP7387590B2 (ja) 2017-09-26 2018-09-25 ラパマイシン誘導体
JP2023081938A Active JP7699626B2 (ja) 2017-09-26 2023-05-18 ラパマイシン誘導体

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Country Status (23)

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US (4) US10800793B2 (OSRAM)
EP (2) EP4365179A3 (OSRAM)
JP (2) JP7387590B2 (OSRAM)
KR (2) KR102794731B1 (OSRAM)
CN (2) CN111094299B (OSRAM)
AR (1) AR112834A1 (OSRAM)
AU (1) AU2018342784B2 (OSRAM)
BR (1) BR112020005898A2 (OSRAM)
CA (1) CA3078191A1 (OSRAM)
DK (1) DK3687999T3 (OSRAM)
ES (1) ES2973975T3 (OSRAM)
FI (1) FI3687999T3 (OSRAM)
HR (1) HRP20240199T8 (OSRAM)
HU (1) HUE065692T2 (OSRAM)
LT (1) LT3687999T (OSRAM)
MX (2) MX2020007265A (OSRAM)
PL (1) PL3687999T3 (OSRAM)
PT (1) PT3687999T (OSRAM)
RS (1) RS65270B1 (OSRAM)
SI (1) SI3687999T1 (OSRAM)
TW (1) TW201920189A (OSRAM)
UY (1) UY37900A (OSRAM)
WO (1) WO2019064182A1 (OSRAM)

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US11708391B2 (en) 2016-02-04 2023-07-25 The Johns Hopkins University Rapaglutins, novel inhibitors of GLUT and use thereof
US11066416B2 (en) 2016-02-04 2021-07-20 The Johns Hopkins University Rapafucin derivative compounds and methods of use thereof
CN113999281A (zh) 2016-02-04 2022-02-01 约翰霍普金斯大学 平衡型核苷转运蛋白1的抑制剂Rapadocin及其用途
UY37900A (es) 2017-09-26 2019-04-30 Novartis Ag Nuevos derivados de rapamicina
PE20212112A1 (es) 2018-05-01 2021-11-04 Revolution Medicines Inc Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor
KR102859103B1 (ko) 2018-05-01 2025-09-12 레볼루션 메디슨즈, 인크. mTOR 억제제로서의 C26-연결된 라파마이신 유사체
EA202092692A1 (ru) 2018-06-15 2021-04-21 Навитор Фармасьютикалз, Инк. Аналоги рапамицина и их применения
FI3898637T3 (fi) 2018-12-18 2025-02-24 Novartis Ag Rapamysiinijohdannaisia
AU2020210921B2 (en) 2019-01-22 2022-02-03 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
ES2987625T3 (es) * 2019-03-26 2024-11-15 Novartis Ag Derivados de rapamicina que contienen 1,1-dióxido de isotiazolidina y 1,4-butanosultona y usos de los mismos
KR102486721B1 (ko) * 2019-08-23 2023-01-10 이화여자대학교 산학협력단 신규 mTOR 억제제 화합물 및 이의 용도
KR102497821B1 (ko) * 2019-08-23 2023-02-08 이화여자대학교 산학협력단 신규 mTOR 억제제 화합물 및 이의 용도
TW202126323A (zh) * 2019-10-01 2021-07-16 約翰斯赫普金斯大學 雷帕弗辛（Ｒａｐａｆｕｃｉｎ）衍生化合物及其使用方法
KR20220128345A (ko) 2019-12-05 2022-09-20 아나쿠리아 테라퓨틱스, 인코포레이티드 라파마이신 유사체 및 이의 용도
DE102020203224A1 (de) 2020-03-12 2021-09-16 Heinrich-Heine-Universität Düsseldorf Inhibition von FKBP1A zur Therapie des Triple-negativen Mammakarzinoms
US20230133761A1 (en) 2020-03-12 2023-05-04 Heinrich-Heine-Universität Düsseldorf Inhibition of fkbp1a for the treatment of triple-negative mammary carcinoma
AU2021241718B2 (en) * 2020-03-27 2025-03-27 Aeovian Pharmaceuticals, Inc. mTORC1 modulators and uses thereof
CN116322677B (zh) * 2020-07-21 2025-09-23 艾奥维安制药公司 Mtorc1调节剂及其用途
TW202206093A (zh) * 2020-08-12 2022-02-16 中國醫藥大學 Ｓｅｍａ３ｄ拮抗劑用於預防或治療神經退化性疾病以及延長壽命之用途
CA3256390A1 (en) 2022-05-25 2023-11-30 Revolution Medicines, Inc. CANCER TREATMENT METHODS USING AN MTOR INHIBITOR
WO2024211738A1 (en) * 2023-04-07 2024-10-10 Regeneron Pharmaceuticals, Inc. Selective rapamycin analogs and uses thereof
WO2024243449A1 (en) * 2023-05-23 2024-11-28 Tornado Therapeutics, Inc. Rapamycin derivatives and uses thereof

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JP2009527520A (ja) 2006-02-24 2009-07-30 ノバルティス アクチエンゲゼルシャフト 神経芽腫を処置するためのラパマイシン誘導体
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