JP7369039B2 - 標的化タンパク質分解 - Google Patents
標的化タンパク質分解 Download PDFInfo
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| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| WO2018085208A1 (en) | 2016-11-02 | 2018-05-11 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction |
| CN111107874A (zh) * | 2017-09-14 | 2020-05-05 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于癌症的组合治疗 |
| BR112020007576A2 (pt) * | 2017-10-18 | 2020-09-24 | Novartis Ag | composições e métodos para degradação de proteína seletiva |
| US12049482B2 (en) * | 2017-10-31 | 2024-07-30 | The Brigham And Women's Hospital, Inc. | Molecular switch-mediated control of engineered cells |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| EP3908329A4 (en) * | 2019-01-07 | 2022-12-07 | The Regents of the University of California | CAGE DEGRON-BASED MOLECULAR FEEDBACK CIRCUITS AND METHODS OF USE THERE |
| KR20210112347A (ko) * | 2019-01-07 | 2021-09-14 | 유니버시티 오브 워싱턴 | 단백질 분해의 조정 가능한 제어를 위한 단백질 스위치의 데노보 설계 |
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| US20230114854A1 (en) * | 2020-02-14 | 2023-04-13 | Cellgentek Co., Ltd. | Chimeric antigen receptor targeting b-cell maturation antigen and use thereof |
| CN114057890A (zh) * | 2020-07-31 | 2022-02-18 | 南京北恒生物科技有限公司 | 新型共刺激结构域及其用途 |
| CN116368152A (zh) * | 2020-09-13 | 2023-06-30 | 山东博安生物技术股份有限公司 | 通过受体tac技术的膜结合蛋白的下调 |
| CN112266404A (zh) * | 2020-10-28 | 2021-01-26 | 北京大学深圳研究生院 | 选择性修饰靶标蛋白的基团转移方法及其应用 |
| CN112940096A (zh) * | 2021-01-29 | 2021-06-11 | 西安交通大学 | 一种膀胱癌血清多肽标志物及其应用 |
| IL304904A (en) * | 2021-02-01 | 2023-10-01 | St Phi Therapeutics Co Ltd | Target protein degradation system and its use |
| CN112980882A (zh) * | 2021-03-15 | 2021-06-18 | 上海科技大学 | Crbn基因在构建GSPT1敏感模型中的用途 |
| NL2031325B1 (en) | 2022-03-18 | 2023-09-29 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Novel zinc finger degron sequences |
| JP2025539386A (ja) | 2022-12-01 | 2025-12-05 | エー・テー・ハー・チューリッヒ | 修飾アミノ酸デグロン（ｍａａｄ）を同定する方法 |
| WO2025248464A2 (en) | 2024-05-29 | 2025-12-04 | Cell Control Biotherapeutics, Inc. | Loop reinforcement expression system for improved cell therapy products |
| CN119699269B (zh) * | 2024-07-10 | 2025-10-17 | 太原市中心医院 | 基于sbsn 600位赖氨酸发生二羟基异丁酰化修饰的用于银屑病研究的小鼠模型构建方法 |
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| EP2818480B1 (en) * | 2012-02-24 | 2020-08-26 | Alteogen Inc. | Modified antibody in which motif comprising cysteine residue is bound, modified antibody-drug conjugate comprising the modified antibody, and production method for same |
| CN103265635A (zh) * | 2013-04-28 | 2013-08-28 | 中山大学附属第一医院 | 一种通用的靶向蛋白嵌合型分子化合物的构建方法 |
| KR20250127179A (ko) * | 2014-04-14 | 2025-08-26 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법 |
| US20170306385A1 (en) * | 2014-10-10 | 2017-10-26 | Dana-Farber Cancer Institute, Inc. | Methods for discovering therapeutics that alter the stability of target proteins |
| EP3347712B1 (en) * | 2015-09-11 | 2022-05-11 | The Broad Institute, Inc. | Methods of identifying drug-modulated polypeptide targets for degradation |
| US10830762B2 (en) * | 2015-12-28 | 2020-11-10 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
| ES2916335T3 (es) * | 2016-10-20 | 2022-06-30 | Celgene Corp | Receptores de antígeno quimérico heterodimerizable basados en cereblon |
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| Journal of Medicinal Chemistry，2017年04月20日，Vol. 61，p. 535-542，doi:10.1021/acs.jmedchem.6b01921 |
| NATURE，2016年04月07日，Vol. 532，p. 127-130, Supplementary Information，doi:10.1038/nature16979 |
| NATURE，2016年06月22日，Vol. 535，p. 252-257, Supplementary Information，doi:10.1038/nature18611 |
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