JP7353671B2 - レーザー光を利用し熱ショックタンパク質の活性化を刺激するように適応させたシステム - Google Patents
レーザー光を利用し熱ショックタンパク質の活性化を刺激するように適応させたシステム Download PDFInfo
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Description
まず、SDMエネルギー送達モードにおけるHSP活性化およびタンパク質修復に対する大きな利点は、およそ10℃のスパイク温度の生成から生じる。この大きな温度上昇は、活性化されるHSPの数を定量的に記述するアレニウス積分およびタンパク質修復を促進するタンパク質への水拡散の速度に対して大きな影響を与える。これは、温度が、大きな増幅効果を有する指数関数(exponential)に入るからである。
I(r)=P/(4πr2) [1]
式中、Pは合計の超音波電力を示す。rでの持続時間tpの短パルスの終端での温度上昇は以下であり、
dT(tp)=Pαtp/(4πCvr2) [2]
式中、αは吸収係数であり、Cvは比熱容量である。tpでの熱拡散距離がrに匹敵するようになるところまでrが達するまで、または集束ビームの回折限界に達するまで、これは当てはまる。より短いrについては、温度上昇は、rとは本質的に無関係である。一例として、回折限界が、熱拡散によって判定された距離より短い半径方向距離で到達されたと仮定する。ここで、
rdif=(4Dtp)1/2 [3]
であり、式中、Dが熱拡散係数であり、r<rdifに関して、tpでの温度上昇は以下である:
r<rdifである場合、dT(rdif,tp)=3Pα/(8πCvD)[4]
したがって、パルスの終端で、温度上昇を記録することができる:
dtp(r)={Pαtp/(4πCv}[(6/rdif 2)U{rdif-r)+(1/r2)U(r-rdif)] [5]
熱拡散方程式に関するグリーン関数:
G(r,t)=(4ΩDt)-3/2 exp[-r2/(4Dt)][6]
をこの初期の温度分布に適用すると、時間tの焦点r=0での温度dT(t)が、以下であることが分かった:
dT(t)=[dTo/{(1/2)+(π1/2/6)}][(1/2)(tp/t)3/2+(π1/2/6)(tp/t)] [7]
とともに
dTo=3Pα/(8πCvD) [8]
Ω=AN[{tp(2kBTo 2/(3EdTo)}exp[-(E/kB)1/(To+dTo+dTN(NtI))]
+exp[-(E/kB)1/(To+dTN(NtI))]] [12]
式中、以下である:
合計の超音波電力: 5.8ワット-17ワット
パルス時間 0.5秒
パルス間隔 5秒
合計の列持続時間(N=10) 50秒
より大きな内容積の処置を促進するために、SAPRAシステムを使用することができる。
Claims (9)
- 標的組織を破損することなく標的組織中の熱ショックタンパク質の活性化を刺激するように適合させたシステムであって、前記システムは、
530nm~1300nmの波長、10%未満のデューティサイクル、および、500ミリ秒以下のパルス幅を有するレーザー光であって、標的組織に電磁的放射エネルギーを適用の結果、標的組織(18)の温度を最大でおよそ摂氏11度上げることによって、標的組織の熱的な時系変化を形成し、その間、標的組織の平均温度が6分以内の時間にわたってわずか摂氏1度以下で上昇するレーザー光を含む、パルス電磁的放射エネルギー源(16)によって特徴づけられる、システム。 - 複数のレーザー光スポットは標的組織に同時に適用される、請求項1に記載のシステム。
- レーザー光は、標的組織に適用される各処置レーザースポット当たりおよそ1ワットの電力を有する、請求項2に記載のシステム。
- 装置(14)は身体の空洞へ挿入され、組織(18)にパルス電磁的放射エネルギーを適用するために使用される、請求項1に記載のシステム。
- 装置は内視鏡を含む、請求項4に記載のシステム。
- パルス電磁的放射エネルギーは、標的組織に隣接しているか、あるいは身体の外側領域の表面近くで血液供給がある身体の外側領域に適用される、請求項1に記載のシステム。
- 身体領域は耳たぶを含み、パルス電磁的放射エネルギーは血液を処置するために耳たぶを流れる血液に適用される、請求項6に記載のシステム。
- レーザー光は標的組織の1平方センチメートル当たり100-590ワットの電力を有する、請求項1に記載のシステム。
- 標的組織温度は、電磁的放射エネルギーの適用中におよそ摂氏10度上げられる、請求項1に記載のシステム。
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