JP7334177B2 - 抗ｃｄ７３抗体及びその使用 - Google Patents

抗ｃｄ７３抗体及びその使用 Download PDF

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JP7334177B2
JP7334177B2 JP2020546997A JP2020546997A JP7334177B2 JP 7334177 B2 JP7334177 B2 JP 7334177B2 JP 2020546997 A JP2020546997 A JP 2020546997A JP 2020546997 A JP2020546997 A JP 2020546997A JP 7334177 B2 JP7334177 B2 JP 7334177B2
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seq
chain variable
variable region
polypeptide sequence
light chain
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JPWO2019173291A5 (enExample
JP2021516057A (ja
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ワン，ミンガン
ゾウ，フイ
ペイ，フェン
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フェインズ セラピューティクス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/922—Ribonucleases (RNAses); Deoxyribonucleases (DNAses)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
JP2020546997A 2018-03-09 2019-03-05 抗ｃｄ７３抗体及びその使用 Active JP7334177B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023132024A JP7636483B2 (ja) 2018-03-09 2023-08-14 抗ｃｄ７３抗体及びその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862640955P 2018-03-09 2018-03-09
US62/640,955 2018-03-09
US201862721044P 2018-08-22 2018-08-22
US62/721,044 2018-08-22
US201862786598P 2018-12-31 2018-12-31
US62/786,598 2018-12-31
PCT/US2019/020688 WO2019173291A1 (en) 2018-03-09 2019-03-05 Anti-cd73 antibodies and uses thereof

Related Child Applications (1)

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JP2023132024A Division JP7636483B2 (ja) 2018-03-09 2023-08-14 抗ｃｄ７３抗体及びその使用

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JP2021516057A JP2021516057A (ja) 2021-07-01
JPWO2019173291A5 JPWO2019173291A5 (enExample) 2022-03-10
JP7334177B2 true JP7334177B2 (ja) 2023-08-28

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JP2023132024A Active JP7636483B2 (ja) 2018-03-09 2023-08-14 抗ｃｄ７３抗体及びその使用

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US (1) US11299550B2 (enExample)
EP (1) EP3762030A4 (enExample)
JP (2) JP7334177B2 (enExample)
KR (2) KR20250065424A (enExample)
CN (2) CN118955714A (enExample)
AU (1) AU2019231172B2 (enExample)
BR (1) BR112020016049A2 (enExample)
CA (1) CA3090008A1 (enExample)
IL (1) IL276950B1 (enExample)
MX (1) MX2020009366A (enExample)
SG (1) SG11202007199XA (enExample)
WO (1) WO2019173291A1 (enExample)
ZA (1) ZA202004827B (enExample)

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MX2020008949A (es) 2018-02-27 2021-01-08 Incyte Corp Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b.
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CN112805299B (zh) 2018-10-05 2025-09-16 西雅图儿童医院以西雅图儿童研究机构名义经营 针对原发性免疫缺陷、胱氨酸病和威尔逊病的新生儿筛查
CN111434688A (zh) * 2019-01-11 2020-07-21 上海开拓者生物医药有限公司 Cd73抗体及其制备方法和应用
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
AU2020353000A1 (en) 2019-09-23 2022-04-07 The Trustees Of The University Of Pennsylvania Disrupting tumor tissues by targeting fibroblast activation protein (FAP)
JP7603670B2 (ja) * 2019-09-23 2024-12-20 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア マウスおよびヒト線維芽細胞活性化タンパク質（ｆａｐ）と交差反応するイヌ線維芽細胞活性化タンパク質に対するモノクローナル抗体
JP7789667B2 (ja) * 2019-11-15 2025-12-22 ジェンザイム・コーポレーション 二重パラトープ性ｃｄ７３抗体
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US20240018254A1 (en) * 2020-10-23 2024-01-18 Akeso Biopharma, Inc Anti-cd73 antibody and use thereof
CN117285630A (zh) * 2020-11-09 2023-12-26 江苏中新医药有限公司 抗cd73单克隆抗体及其在制备肿瘤药物中的应用
TWI900705B (zh) * 2020-12-11 2025-10-11 大陸商上海華奧泰生物藥業股份有限公司 Ｃｄ７３的抗原結合蛋白及其應用
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CN113061177B (zh) * 2020-12-31 2022-07-01 浙江大学 一种cd73酶活性相关的抗原表位及针对该表位的特异性抗体的制备方法
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WO2024243189A2 (en) * 2023-05-22 2024-11-28 Board Of Regents, The University Of Texas System Antigen binding proteins targeting pd-1
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JP2018501197A (ja) 2014-11-10 2018-01-18 メディミューン リミテッド Ｃｄ７３特異的結合分子及びその使用
WO2017152085A1 (en) 2016-03-04 2017-09-08 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
US20180009899A1 (en) 2016-07-11 2018-01-11 Corvus Pharmaceuticals, Inc. Anti-cd73 antibodies

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WO2019173291A1 (en) 2019-09-12
AU2019231172A1 (en) 2020-09-03
CA3090008A1 (en) 2019-09-12
MX2020009366A (es) 2020-10-14
NZ766968A (en) 2024-12-20
JP7636483B2 (ja) 2025-02-26
ZA202004827B (en) 2023-06-28
KR20250065424A (ko) 2025-05-12
BR112020016049A2 (pt) 2020-12-08
US20200399389A1 (en) 2020-12-24
CN111867628A (zh) 2020-10-30
IL276950B1 (en) 2025-12-01
AU2019231172B2 (en) 2023-08-24
EP3762030A4 (en) 2022-01-05
US11299550B2 (en) 2022-04-12
KR102804816B1 (ko) 2025-05-09
CN118955714A (zh) 2024-11-15
CN111867628B (zh) 2024-08-23
JP2023162257A (ja) 2023-11-08
IL276950A (en) 2020-10-29
KR20200128542A (ko) 2020-11-13
EP3762030A1 (en) 2021-01-13
SG11202007199XA (en) 2020-09-29
JP2021516057A (ja) 2021-07-01

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