JP7327858B2 - ペプチド化合物の製造方法及びアミド化反応剤 - Google Patents

ペプチド化合物の製造方法及びアミド化反応剤 Download PDF

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Publication number
JP7327858B2
JP7327858B2 JP2022565830A JP2022565830A JP7327858B2 JP 7327858 B2 JP7327858 B2 JP 7327858B2 JP 2022565830 A JP2022565830 A JP 2022565830A JP 2022565830 A JP2022565830 A JP 2022565830A JP 7327858 B2 JP7327858 B2 JP 7327858B2
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group
formula
substituents
hydrocarbon group
compound
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Japanese (ja)
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JPWO2022255195A1 (https=
JPWO2022255195A5 (https=
Inventor
尚 山本
倫弘 服部
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Chubu University
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Chubu University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022565830A 2021-05-31 2022-05-25 ペプチド化合物の製造方法及びアミド化反応剤 Active JP7327858B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021091438 2021-05-31
JP2021091438 2021-05-31
PCT/JP2022/021434 WO2022255195A1 (ja) 2021-05-31 2022-05-25 ペプチド化合物の製造方法及びアミド化反応剤

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JPWO2022255195A1 JPWO2022255195A1 (https=) 2022-12-08
JPWO2022255195A5 JPWO2022255195A5 (https=) 2023-05-15
JP7327858B2 true JP7327858B2 (ja) 2023-08-16

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JP2022565830A Active JP7327858B2 (ja) 2021-05-31 2022-05-25 ペプチド化合物の製造方法及びアミド化反応剤

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Country Link
US (1) US20240368217A1 (https=)
EP (1) EP4349848A4 (https=)
JP (1) JP7327858B2 (https=)
WO (1) WO2022255195A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7625769B1 (ja) * 2023-03-01 2025-02-03 学校法人中部大学 新規シリルタグを用いたペプチド化合物の製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009507906A (ja) 2005-09-13 2009-02-26 ユニヴァーシティー オブ リーディング ペプチドの不斉合成
WO2009060843A1 (ja) 2007-11-09 2009-05-14 Gifu University アミド化触媒、カルボン酸アミドの製造方法、及びペプチドの製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6744669B2 (ja) 2016-05-23 2020-08-19 学校法人中部大学 水酸基を配向基とするエステルからアミドへの変換触媒
CN110662736A (zh) 2017-04-25 2020-01-07 学校法人中部大学 酰胺化合物的制造方法
JPWO2018199146A1 (ja) 2017-04-25 2020-02-27 学校法人中部大学 オキシム・ヒドロキシアミンを基質とするエステルからアミドへの変換触媒
CN112020492B (zh) 2018-04-25 2023-05-05 学校法人中部大学 酰胺化合物的制造方法
JP7244134B2 (ja) 2019-10-30 2023-03-22 学校法人中部大学 アミド反応用反応剤及びそれを用いたアミド化合物の製造方法
EP4053101A4 (en) 2019-10-30 2024-02-21 Chubu University Educational Foundation REACTANT FOR AMIDE REACTION AND METHOD FOR PRODUCING AN AMIDE COMPOUND USING THE SAME
US20230121469A1 (en) 2020-01-22 2023-04-20 Chubu University Educational Foundation Catalyst for manufacturing amide compound, and method for manufacturing amide compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009507906A (ja) 2005-09-13 2009-02-26 ユニヴァーシティー オブ リーディング ペプチドの不斉合成
WO2009060843A1 (ja) 2007-11-09 2009-05-14 Gifu University アミド化触媒、カルボン酸アミドの製造方法、及びペプチドの製造方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHUNG, S. W. et al.，Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids，SYNLETT，2011年，No. 14，pp.2072-2074
DUBOIS, N. et al.，On DABAL-Me3 promoted formation of amides，Tetrahedron，2013年，Vol.69，pp.9890-9897
LI, J. et al.，AlMe3-Promoted Formation of Amides from Acids and Amines，Org. Lett.，2012年，Vol. 14, No. 1，pp.214-217
MARTIN, S. F. et al.，APPLICATION OF AIMe3-MEDIATED AMIDATION REACTIONS TO SOLUTION PHASE PEPTIDE SYNTHESIS，Tetrahedron Letters，1998年，Vol.39，pp.1517-1520
MURAMATSU, W. et al.，Game Change from Reagent- to Substrate-Controlled Peptide Synthesis，Bull. Chem. Soc. Jpn.，2020年，Vol.93，pp.759-767
MURAMATSU, W. et al.，Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis，J. Am. Chem. Soc.，2019年，Vol.141，pp.12288-12295

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Publication number Publication date
JPWO2022255195A1 (https=) 2022-12-08
WO2022255195A1 (ja) 2022-12-08
US20240368217A1 (en) 2024-11-07
EP4349848A4 (en) 2024-11-27
EP4349848A1 (en) 2024-04-10

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