JP7325407B2 - ガレクチン－３タンパク質に対する特異的結合分子 - Google Patents

ガレクチン－３タンパク質に対する特異的結合分子 Download PDF

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JP7325407B2
JP7325407B2 JP2020519382A JP2020519382A JP7325407B2 JP 7325407 B2 JP7325407 B2 JP 7325407B2 JP 2020519382 A JP2020519382 A JP 2020519382A JP 2020519382 A JP2020519382 A JP 2020519382A JP 7325407 B2 JP7325407 B2 JP 7325407B2
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Prior art keywords
specific binding
binding molecule
seq
fusion protein
antibody
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Japanese (ja)
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JP2021500874A5 (https=
JP2021500874A (ja
Inventor
フォンテーヌ，アレクサンドル
モンドン，フィリップ
ラロシュ－トレノー，ジェニー
ジャコバン－ヴァラ，マリ－ジョゼ
チェルッティ，マルティーヌ
クロフェント－サンチェス，ジゼル
ロレンツァート，シリル
ヘマドウ，オドレイ
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Centre National de la Recherche Scientifique CNRS
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Centre National de la Recherche Scientifique CNRS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020519382A 2017-10-05 2018-10-05 ガレクチン－３タンパク質に対する特異的結合分子 Active JP7325407B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17306337.1A EP3466975A1 (en) 2017-10-05 2017-10-05 A specific binding molecule directed against galectin-3 protein
EP17306337.1 2017-10-05
PCT/EP2018/077131 WO2019068863A1 (en) 2017-10-05 2018-10-05 SPECIFIC BINDING MOLECULE DIRECTED AGAINST GALECTIN-3 PROTEIN

Publications (3)

Publication Number Publication Date
JP2021500874A JP2021500874A (ja) 2021-01-14
JP2021500874A5 JP2021500874A5 (https=) 2021-10-28
JP7325407B2 true JP7325407B2 (ja) 2023-08-14

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ID=60119974

Family Applications (1)

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JP2020519382A Active JP7325407B2 (ja) 2017-10-05 2018-10-05 ガレクチン－３タンパク質に対する特異的結合分子

Country Status (4)

Country Link
US (1) US11091552B2 (https=)
EP (2) EP3466975A1 (https=)
JP (1) JP7325407B2 (https=)
WO (1) WO2019068863A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
AU2019215202B2 (en) * 2018-02-01 2025-11-13 Memorial Sloan Kettering Cancer Center Antibodies to Galectin-3 and methods of use thereof
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) * 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
WO2022125482A1 (en) * 2020-12-08 2022-06-16 Memorial Sloan Kettering Cancer Center Antibodies to galectin-3 and methods of use thereof
CN115746134A (zh) * 2021-10-15 2023-03-07 深圳市睿盟创新生物科技有限公司 半乳糖凝集素-3的免疫测定
CN118524852A (zh) * 2021-11-09 2024-08-20 真和制药有限公司 治疗或抑制心血管疾病的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112559A1 (en) 2007-03-09 2008-09-18 Regents Of The University Of California Suppression of galectin-3 for treating an inflammatory condition
JP2010533850A (ja) 2007-07-19 2010-10-28 ビオメリュー 結腸直腸癌のインビトロ診断のためのアミノアシラーゼ１・アッセイ方法
JP2012507724A (ja) 2008-10-29 2012-03-29 ビージー メディシン， インコーポレイテッド ガレクチン−３の免疫アッセイ
WO2016004093A2 (en) 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof
JP2017512205A (ja) 2014-03-10 2017-05-18 ラ ホヤ ファーマシューティカル カンパニーＬａ Ｊｏｌｌａ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｍｐａｎｙ 腎臓障害を治療するための組成物及び方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
WO2007137616A1 (en) 2006-05-30 2007-12-06 Millegen Highly diversified antibody libraries

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112559A1 (en) 2007-03-09 2008-09-18 Regents Of The University Of California Suppression of galectin-3 for treating an inflammatory condition
JP2010533850A (ja) 2007-07-19 2010-10-28 ビオメリュー 結腸直腸癌のインビトロ診断のためのアミノアシラーゼ１・アッセイ方法
JP2012507724A (ja) 2008-10-29 2012-03-29 ビージー メディシン， インコーポレイテッド ガレクチン−３の免疫アッセイ
JP2017512205A (ja) 2014-03-10 2017-05-18 ラ ホヤ ファーマシューティカル カンパニーＬａ Ｊｏｌｌａ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｍｐａｎｙ 腎臓障害を治療するための組成物及び方法
WO2016004093A2 (en) 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof

Also Published As

Publication number Publication date
US11091552B2 (en) 2021-08-17
WO2019068863A1 (en) 2019-04-11
US20210079101A1 (en) 2021-03-18
EP3466975A1 (en) 2019-04-10
JP2021500874A (ja) 2021-01-14
EP3692067A1 (en) 2020-08-12

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