JP7320448B2 - 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物 - Google Patents

脳への薬剤送達用のキャリアおよびこれを含んでなる組成物 Download PDF

Info

Publication number
JP7320448B2
JP7320448B2 JP2019517686A JP2019517686A JP7320448B2 JP 7320448 B2 JP7320448 B2 JP 7320448B2 JP 2019517686 A JP2019517686 A JP 2019517686A JP 2019517686 A JP2019517686 A JP 2019517686A JP 7320448 B2 JP7320448 B2 JP 7320448B2
Authority
JP
Japan
Prior art keywords
polymer
molecular weight
average molecular
blood
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019517686A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2018207864A1 (ja
Inventor
一則 片岡
泰孝 安楽
乃理子 中村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kawasaki Institute of Industrial Promotion
Original Assignee
Kawasaki Institute of Industrial Promotion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawasaki Institute of Industrial Promotion filed Critical Kawasaki Institute of Industrial Promotion
Publication of JPWO2018207864A1 publication Critical patent/JPWO2018207864A1/ja
Application granted granted Critical
Publication of JP7320448B2 publication Critical patent/JP7320448B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019517686A 2017-05-11 2018-05-10 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物 Active JP7320448B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017095055 2017-05-11
JP2017095055 2017-05-11
PCT/JP2018/018073 WO2018207864A1 (fr) 2017-05-11 2018-05-10 Véhicule pour l'administration d'un médicament au cerveau, et composition le contenant

Publications (2)

Publication Number Publication Date
JPWO2018207864A1 JPWO2018207864A1 (ja) 2020-03-19
JP7320448B2 true JP7320448B2 (ja) 2023-08-03

Family

ID=64105124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019517686A Active JP7320448B2 (ja) 2017-05-11 2018-05-10 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物

Country Status (2)

Country Link
JP (1) JP7320448B2 (fr)
WO (1) WO2018207864A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023199723A1 (fr) * 2022-04-14 2023-10-19 国立研究開発法人量子科学技術研究開発機構 Particules de polymère unique, complexe moléculaire actif, procédé de production de particules de polymère unique, procédé de mesure de la taille d'une tumeur, procédé de mesure d'une structure fine à l'intérieur d'une tumeur, procédé d'imagerie de tissu biologique, système d'administration de médicament et kit d'agent de contraste

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015075942A1 (fr) 2013-11-22 2015-05-28 国立大学法人 東京大学 Vecteur d'apport de médicament et conjugué, composition le contenant, et son procédé d'administration
WO2017002979A1 (fr) 2015-07-02 2017-01-05 国立大学法人 東京大学 Vecteur d'administration de médicament, et composition le contenant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015075942A1 (fr) 2013-11-22 2015-05-28 国立大学法人 東京大学 Vecteur d'apport de médicament et conjugué, composition le contenant, et son procédé d'administration
WO2017002979A1 (fr) 2015-07-02 2017-01-05 国立大学法人 東京大学 Vecteur d'administration de médicament, et composition le contenant

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ISHII, T. et al.，Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths，Chem. Commun.，2016年，Vol. 52，pp. 1517-1519
SAWANT, R. R. et al.，The architecture of ligand attachment to nanocarriers controls their specific interaction with targe，J. Drug Target.，2008年，Vol. 16, No. 7，pp. 596-600
UCHIDA, K. et al.，A Reactive Poly(ethylene glycol) Layer To Achieve Specific Surface Plasmon Resonance Sensing with a，Anal. Chem.，2005年，Vol. 77, No. 4，pp. 1075-1080
中村乃理子 ほか，血液脳関門突破を指向した高分子ミセル表層のリガンド分子の標的認識能評価，第３９回日本バイオマテリアル学会大会 予稿集，2017年11月13日，p. 183，2B-05-II

Also Published As

Publication number Publication date
WO2018207864A1 (fr) 2018-11-15
JPWO2018207864A1 (ja) 2020-03-19

Similar Documents

Publication Publication Date Title
JP6782415B2 (ja) 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法
JP4796063B2 (ja) 治療薬を送達するための方法および物
Ding et al. Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions
Wang et al. Polylactide-cholesterol stereocomplex micelle encapsulating chemotherapeutic agent for improved antitumor efficacy and safety
Song et al. Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy
Xu et al. Biodistribution and pharmacokinetics of EGFR-targeted thiolated gelatin nanoparticles following systemic administration in pancreatic tumor-bearing mice
Mohamed et al. Polymeric nano-micelles: versatile platform for targeted delivery in cancer
JP6797415B2 (ja) 薬剤送達用キャリア及びこれを含む組成物
JP2011105792A (ja) ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
JP6853924B2 (ja) 温度感受性重合体を用いた核酸の送達用ミセル組成物およびその製造方法
Yin et al. Novel chitosan derivatives with reversible cationization and hydrophobicization for tumor cytoplasm-specific burst co-delivery of siRNA and chemotherapeutics
Jackson et al. Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes
Xie et al. Targeted folate-conjugated pluronic P85/poly (lactide-co-glycolide) polymersome for the oral delivery of insulin
JPWO2019240223A1 (ja) 数平均分子量が３ｋＤａ〜１０ｋＤａであるＰＥＧブロックとカチオン性ポリマーとのブロックコポリマーと、アンチセンスオリゴヌクレオチドとを含む、ポリイオンコンプレックスミセル
US20140296173A1 (en) Stable nanocomposition comprising epirubicin, process for the preparation thereof, its use and pharmaceutical compositions containing it
Wang et al. Multifunctional nanoparticles loading with docetaxel and GDC0941 for reversing multidrug resistance mediated by PI3K/Akt signal pathway
CN113646003A (zh) 多配体官能化的聚合物泡囊
JP7320448B2 (ja) 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物
Liu et al. Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform
WO2020230793A1 (fr) Technologie permettant de commander la migration de nanoparticules creuses vers le cerveau à partir du sang
Ahirwar et al. Harnessing the potential of nanoengineered siRNAs carriers for target responsive glioma therapy: Recent progress and future opportunities
Xiao et al. Nanotherapeutics for Inflammatory Bowel Disease
Şalva et al. Characteristics of Marketed Nanopharmaceutics
JP2021178779A (ja) 十分な血中滞留性を有し、かつ、グリア限界膜への透過性が改善されたポリイオンコンプレックス型ポリマーソーム
Karim Design of Nanocarriers to Deliver Small Hydrophobic Molecules for Glioblastoma Treatment

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210427

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220531

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220728

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221129

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230127

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230327

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230627

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230724

R150 Certificate of patent or registration of utility model

Ref document number: 7320448

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150