JP7318987B2 - セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法 - Google Patents
セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法 Download PDFInfo
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- JP7318987B2 JP7318987B2 JP2021536123A JP2021536123A JP7318987B2 JP 7318987 B2 JP7318987 B2 JP 7318987B2 JP 2021536123 A JP2021536123 A JP 2021536123A JP 2021536123 A JP2021536123 A JP 2021536123A JP 7318987 B2 JP7318987 B2 JP 7318987B2
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Description
Claims (14)
- 鎮痛のための医薬品製剤であって、
前記医薬品製剤は、
セバコイルジナルブフィン(sebacoyl dinalbuphine)又は薬学的に許容される塩である治療有効量の第1鎮痛剤及び、
アセトアミノフェン(acetaminophen、AAP)である治療有効量の第2鎮痛剤と、
一つ又は複数の薬学的に許容される賦形剤と
を含む
ことを特徴とする医薬品製剤。 - 前記一つ又は複数の薬学的に許容される賦形剤は、ポリ(メタクリル酸―co―メチルメタクリレート)、脱水リン酸二カルシウム(Dicalcium phosphate dehydrate)、プロピレングリコールブロックポリエーテル、ヘキシトール(Hexitol)、クロスポビドン(Crospovidone)、デンプングリコール酸ナトリウム(Sodium starch glycolate)、フュームドシリカ、トリクロロスクロース(Trichlorosucrose)、メントール(Menthol)、サッカリン(Saccharin)、安息香酸ナトリウム(Sodium benzoate)、ベヘン酸グリセリル(Glyceryl behenate)、ラウリル硫酸ナトリウム(Sodium lauryl sulfate)、ポリビニルピロリドン、及びこれらの複合体からなる群より選択される
ことを特徴とする請求項1に記載の医薬品製剤。 - 前記第1鎮痛剤と前記第2鎮痛剤との組み合わせを含む
ことを特徴とする請求項1に記載の医薬品製剤。 - 前記第1鎮痛剤は、遊離塩基の形のセバコイルジナルブフィン(sebacoyl dinalbuphine)又は薬学的に許容される塩である
ことを特徴とする請求項1に記載の医薬品製剤。 - 鎮痛のための医薬品製剤であって、
前記医薬品製剤は、
(i)セバコイルジナルブフィン(sebacoyl dinalbuphine)又は薬学的に許容される塩である治療有効量の第1鎮痛剤を含む第1鎮痛剤組成物と、
(ii)アセトアミノフェン(acetaminophen、AAP)である治療有効量の第2鎮痛剤を含む第2鎮痛剤組成物と
を含む
ことを特徴とする医薬品製剤。 - ポリ(メタクリル酸―co―メチルメタクリレート)、脱水リン酸二カルシウム(Dicalcium phosphate dehydrate)、プロピレングリコールブロックポリエーテル、ヘキシトール(Hexitol)、クロスポビドン(Crospovidone)、デンプングリコール酸ナトリウム(Sodium starch glycolate)、フュームドシリカ、トリクロロスクロース(Trichlorosucrose)、メントール(Menthol)、サッカリン(Saccharin)、安息香酸ナトリウム(Sodium benzoate)、ベヘン酸グリセリル(Glyceryl behenate)、ラウリル硫酸ナトリウム(Sodium lauryl sulfate)、ポリビニルピロリドン、及びこれらの組み合わせからなる群より選択された一つ又は複数の薬学的に許容される賦形剤を含む
ことを特徴とする請求項5に記載の医薬品製剤。 - キャリア及びバランスとして一つ又は複数の追加の賦形剤をさらに含む
ことを特徴とする請求項6に記載の医薬品製剤。 - 総合・相乗的な(summation/synergistic)鎮痛効果を提供する
ことを特徴とする請求項5に記載の医薬品製剤。 - 前記第1鎮痛剤組成物又は前記第2鎮痛剤組成物をそれぞれ比較した場合、前記総合・相乗的な鎮痛効果は、より高い有効性、より速い鎮痛効果の発生、及び/又はより長い鎮痛効果の期間を含む
ことを特徴とする請求項8に記載の医薬品製剤。 - 前記第1鎮痛剤組成物における前記第1鎮痛剤又は前記第2鎮痛剤組成物における前記第2鎮痛剤をそれぞれ比較した場合の値は、前記総合・相乗的な鎮痛効果に含む前記第1鎮痛剤組成物における前記第1鎮痛剤と前記第2鎮痛剤組成物における前記第2鎮痛剤の一つ又は複数の薬物動態パラメーターの量が増加する
ことを特徴とする請求項8に記載の医薬品製剤。 - 前記第1鎮痛剤は、遊離塩基の形のセバコイルジナルブフィン(sebacoyl dinalbuphine)又は薬学的に許容される塩である
ことを特徴とする請求項5に記載の医薬品製剤。 - 前記医薬品製剤は、ゲル、スプレー、エマルジョン、トローチ剤、分散性錠剤、錠剤、腸溶性コーティング剤、カプセル、ソフトカプセル剤、顆粒、懸濁液、ミクロスフェア、口腔インプラント、筋肉注射、静脈注射、埋め込み型注射、放出調節剤、及び他の薬学的に許容される形態で投与される
ことを特徴とする請求項1~11のいずれかに記載の医薬品製剤。 - 鎮痛のための医薬品の製造のための請求項1~12のいずれかに記載の医薬品製剤の使用。
- 必要がある個体の疼痛を治療するための請求項1~12のいずれかに記載の医薬品製剤。
Priority Applications (1)
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JP2023060264A JP2023078480A (ja) | 2018-09-03 | 2023-04-03 | セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法 |
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PCT/CN2018/103786 WO2020047703A1 (en) | 2018-09-03 | 2018-09-03 | Pharmaceutical preparations of sebacoyl dinalbuphine and acetaminophen and methods for treating pain |
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JP2023060264A Division JP2023078480A (ja) | 2018-09-03 | 2023-04-03 | セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法 |
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JP2021535216A JP2021535216A (ja) | 2021-12-16 |
JP7318987B2 true JP7318987B2 (ja) | 2023-08-01 |
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JP2021536123A Active JP7318987B2 (ja) | 2018-09-03 | 2018-09-03 | セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法 |
JP2023060264A Pending JP2023078480A (ja) | 2018-09-03 | 2023-04-03 | セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法 |
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Country | Link |
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EP (1) | EP3846815A4 (ja) |
JP (2) | JP7318987B2 (ja) |
KR (1) | KR20210054560A (ja) |
CN (1) | CN113164469A (ja) |
AU (1) | AU2018440280B2 (ja) |
CA (1) | CA3111271A1 (ja) |
CL (1) | CL2021000309A1 (ja) |
IL (1) | IL280822A (ja) |
SG (1) | SG11202101974WA (ja) |
WO (1) | WO2020047703A1 (ja) |
ZA (1) | ZA202102209B (ja) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004054511A3 (en) | 2002-12-13 | 2004-11-11 | Univ California | Analgesic combination comprising nalbuphine |
WO2008107410A1 (en) | 2007-03-02 | 2008-09-12 | Flamek Corp Oü | Analgesic composition of topically applied nonsteroidal antiinflammatory drugs and opioids |
JP2016520100A (ja) | 2013-11-13 | 2016-07-11 | ▲財▼▲団▼法人国防教育研究基金会National Defense Education And Research Foundation | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4237140A (en) * | 1979-05-18 | 1980-12-02 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and acetaminophen |
US6225321B1 (en) * | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
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- 2018-09-03 SG SG11202101974WA patent/SG11202101974WA/en unknown
- 2018-09-03 CA CA3111271A patent/CA3111271A1/en active Pending
- 2018-09-03 AU AU2018440280A patent/AU2018440280B2/en active Active
- 2018-09-03 WO PCT/CN2018/103786 patent/WO2020047703A1/en unknown
- 2018-09-03 JP JP2021536123A patent/JP7318987B2/ja active Active
- 2018-09-03 KR KR1020217009905A patent/KR20210054560A/ko active IP Right Grant
- 2018-09-03 EP EP18932827.1A patent/EP3846815A4/en active Pending
- 2018-09-03 CN CN201880096947.3A patent/CN113164469A/zh active Pending
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2021
- 2021-02-05 CL CL2021000309A patent/CL2021000309A1/es unknown
- 2021-02-11 IL IL280822A patent/IL280822A/en unknown
- 2021-03-31 ZA ZA2021/02209A patent/ZA202102209B/en unknown
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2023
- 2023-04-03 JP JP2023060264A patent/JP2023078480A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004054511A3 (en) | 2002-12-13 | 2004-11-11 | Univ California | Analgesic combination comprising nalbuphine |
WO2008107410A1 (en) | 2007-03-02 | 2008-09-12 | Flamek Corp Oü | Analgesic composition of topically applied nonsteroidal antiinflammatory drugs and opioids |
JP2016520100A (ja) | 2013-11-13 | 2016-07-11 | ▲財▼▲団▼法人国防教育研究基金会National Defense Education And Research Foundation | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
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Publication number | Publication date |
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CL2021000309A1 (es) | 2021-07-19 |
EP3846815A1 (en) | 2021-07-14 |
CN113164469A (zh) | 2021-07-23 |
EP3846815A4 (en) | 2022-05-04 |
WO2020047703A1 (en) | 2020-03-12 |
AU2018440280B2 (en) | 2022-11-03 |
KR20210054560A (ko) | 2021-05-13 |
ZA202102209B (en) | 2022-03-30 |
SG11202101974WA (en) | 2021-03-30 |
JP2023078480A (ja) | 2023-06-06 |
CA3111271A1 (en) | 2020-03-12 |
JP2021535216A (ja) | 2021-12-16 |
AU2018440280A1 (en) | 2021-03-18 |
IL280822A (en) | 2021-04-29 |
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