JP7317805B2 - フォン・ヴィレブランド因子に関連する合併症及び障害の処置のための組成物及び方法 - Google Patents
フォン・ヴィレブランド因子に関連する合併症及び障害の処置のための組成物及び方法 Download PDFInfo
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- JP7317805B2 JP7317805B2 JP2020514147A JP2020514147A JP7317805B2 JP 7317805 B2 JP7317805 B2 JP 7317805B2 JP 2020514147 A JP2020514147 A JP 2020514147A JP 2020514147 A JP2020514147 A JP 2020514147A JP 7317805 B2 JP7317805 B2 JP 7317805B2
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Classifications
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- C12N2320/00—Applications; Uses
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- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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| JP2023061093A JP7781815B2 (ja) | 2017-05-19 | 2023-04-05 | フォン・ヴィレブランド因子に関連する合併症及び障害の処置のための組成物及び方法 |
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| US201862638579P | 2018-03-05 | 2018-03-05 | |
| US62/638,579 | 2018-03-05 | ||
| PCT/US2018/033376 WO2018213697A1 (en) | 2017-05-19 | 2018-05-18 | Compositions and methods for the treatment of complications and disorders relating to von willebrand factor |
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| JP2023061093A Division JP7781815B2 (ja) | 2017-05-19 | 2023-04-05 | フォン・ヴィレブランド因子に関連する合併症及び障害の処置のための組成物及び方法 |
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| JP2023061093A Active JP7781815B2 (ja) | 2017-05-19 | 2023-04-05 | フォン・ヴィレブランド因子に関連する合併症及び障害の処置のための組成物及び方法 |
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| JP (2) | JP7317805B2 (https=) |
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| WO2021158583A1 (en) * | 2020-02-04 | 2021-08-12 | Band Therapeutics, Llc | Regulation of von willebrand factor (vwf) |
| KR20220150303A (ko) * | 2020-02-04 | 2022-11-10 | 다케다 야쿠힌 고교 가부시키가이샤 | 재조합 vwf의 투여에 의한 중증 폰 빌레브란트병 환자의 월경과다 치료 |
| US20240002861A1 (en) * | 2020-11-24 | 2024-01-04 | Band Therapeutics, Llc | Compositions and methods for treatment of bleeding disorders |
| CN116723863A (zh) * | 2020-11-24 | 2023-09-08 | 邦德治疗有限公司 | 用于治疗出血性病症的组合物和方法 |
| US12090243B2 (en) | 2021-03-24 | 2024-09-17 | Aleo Bme, Inc. | Compositions comprising fluid gels for tissue separation |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008512098A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
| US20090170793A1 (en) | 2005-06-01 | 2009-07-02 | Gaur Rajesh K | Artificial riboswitch for controlling pre-mrna splicing |
| US20090203766A1 (en) | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
| WO2010091396A2 (en) | 2009-02-09 | 2010-08-12 | Archemix Corp. | Aptamers to von willerbrand factor and their use as thrombotic, hematologic and cardiovascular disease therapeutics |
| US20110118187A1 (en) | 2006-10-19 | 2011-05-19 | Duke University | Reversible platelet inhibition |
| WO2015163458A1 (ja) | 2014-04-24 | 2015-10-29 | 株式会社リボミック | オートタキシンに結合しオートタキシンの生理活性を阻害するアプタマー及びその利用 |
| WO2016143700A1 (ja) | 2015-03-06 | 2016-09-15 | タグシクス・バイオ株式会社 | Dnaアプタマーの安定化法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| KR102640903B1 (ko) | 2015-10-30 | 2024-02-27 | 탁시스 바이오 가부시키가이샤 | vWF에 결합하는 DNA 앱타머 |
| WO2021158583A1 (en) * | 2020-02-04 | 2021-08-12 | Band Therapeutics, Llc | Regulation of von willebrand factor (vwf) |
| US20240002861A1 (en) * | 2020-11-24 | 2024-01-04 | Band Therapeutics, Llc | Compositions and methods for treatment of bleeding disorders |
| WO2023039522A1 (en) * | 2021-09-10 | 2023-03-16 | Guardian Therapeutics, Llc | Fatty acid conjugates of nucleic acids |
-
2018
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008512098A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
| US20090170793A1 (en) | 2005-06-01 | 2009-07-02 | Gaur Rajesh K | Artificial riboswitch for controlling pre-mrna splicing |
| US20110118187A1 (en) | 2006-10-19 | 2011-05-19 | Duke University | Reversible platelet inhibition |
| US20090203766A1 (en) | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
| WO2010091396A2 (en) | 2009-02-09 | 2010-08-12 | Archemix Corp. | Aptamers to von willerbrand factor and their use as thrombotic, hematologic and cardiovascular disease therapeutics |
| WO2015163458A1 (ja) | 2014-04-24 | 2015-10-29 | 株式会社リボミック | オートタキシンに結合しオートタキシンの生理活性を阻害するアプタマー及びその利用 |
| WO2016143700A1 (ja) | 2015-03-06 | 2016-09-15 | タグシクス・バイオ株式会社 | Dnaアプタマーの安定化法 |
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| US20210292763A1 (en) | 2021-09-23 |
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| IL269641A (en) | 2019-11-28 |
| JP7781815B2 (ja) | 2025-12-08 |
| KR20200008122A (ko) | 2020-01-23 |
| WO2018213697A1 (en) | 2018-11-22 |
| KR102830459B1 (ko) | 2025-07-09 |
| TW201900877A (zh) | 2019-01-01 |
| AU2018269935A1 (en) | 2019-11-28 |
| CN117487811A (zh) | 2024-02-02 |
| RU2019136508A (ru) | 2021-06-22 |
| EP3624801A1 (en) | 2020-03-25 |
| MX390865B (es) | 2025-03-12 |
| CN110520128B (zh) | 2023-11-14 |
| CA3058001A1 (en) | 2018-11-22 |
| NZ758741A (en) | 2025-09-26 |
| US20200165612A1 (en) | 2020-05-28 |
| JP2023093535A (ja) | 2023-07-04 |
| RU2019136508A3 (https=) | 2022-02-14 |
| AU2018269935B2 (en) | 2024-05-16 |
| TWI806868B (zh) | 2023-07-01 |
| US20260092283A1 (en) | 2026-04-02 |
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