TWI806868B - 治療與類血友病因子有關的併發症和疾病之組成物和方法 - Google Patents

治療與類血友病因子有關的併發症和疾病之組成物和方法 Download PDF

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TWI806868B
TWI806868B TW107116981A TW107116981A TWI806868B TW I806868 B TWI806868 B TW I806868B TW 107116981 A TW107116981 A TW 107116981A TW 107116981 A TW107116981 A TW 107116981A TW I806868 B TWI806868 B TW I806868B
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Taiwan
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vwf
synthetic polynucleotide
aptamer
blood
occlusive
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TW107116981A
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English (en)
Chinese (zh)
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TW201900877A (zh
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曙灝 朱
詹姆士 吉伯特
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美商邦德治療公司
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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TW107116981A 2017-05-19 2018-05-18 治療與類血友病因子有關的併發症和疾病之組成物和方法 TWI806868B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762508530P 2017-05-19 2017-05-19
US62/508,530 2017-05-19
US201862638579P 2018-03-05 2018-03-05
US62/638,579 2018-03-05

Publications (2)

Publication Number Publication Date
TW201900877A TW201900877A (zh) 2019-01-01
TWI806868B true TWI806868B (zh) 2023-07-01

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TW107116981A TWI806868B (zh) 2017-05-19 2018-05-18 治療與類血友病因子有關的併發症和疾病之組成物和方法

Country Status (11)

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US (3) US11060094B2 (https=)
EP (1) EP3624801A4 (https=)
JP (2) JP7317805B2 (https=)
KR (1) KR102830459B1 (https=)
CN (2) CN110520128B (https=)
AU (1) AU2018269935B2 (https=)
CA (1) CA3058001A1 (https=)
IL (1) IL269641B2 (https=)
MX (1) MX390865B (https=)
TW (1) TWI806868B (https=)
WO (1) WO2018213697A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230038761A1 (en) * 2020-02-04 2023-02-09 Band Therapeutics, Llc Regulation of von willebrand factor (vwf)
CN115335074A (zh) * 2020-02-04 2022-11-11 武田药品工业株式会社 通过施用重组vwf来治疗患有重度冯维勒布兰德病的患者的月经过多
TW202237149A (zh) * 2020-11-24 2022-10-01 美商邦德治療公司 用於治療出血性障礙之組成物及方法
CN116723863A (zh) * 2020-11-24 2023-09-08 邦德治疗有限公司 用于治疗出血性病症的组合物和方法
US12090243B2 (en) 2021-03-24 2024-09-17 Aleo Bme, Inc. Compositions comprising fluid gels for tissue separation

Citations (2)

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US20090170793A1 (en) * 2005-06-01 2009-07-02 Gaur Rajesh K Artificial riboswitch for controlling pre-mrna splicing
WO2010091396A2 (en) * 2009-02-09 2010-08-12 Archemix Corp. Aptamers to von willerbrand factor and their use as thrombotic, hematologic and cardiovascular disease therapeutics

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US7566701B2 (en) 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
EP1789096A4 (en) * 2004-09-07 2009-07-08 Archemix Corp APTAMERS FOR THE VON WILLEBRAND FACTOR AND ITS USE AS THERAPEUTICS FOR THROMBOTIC DISEASES
US20110118187A1 (en) * 2006-10-19 2011-05-19 Duke University Reversible platelet inhibition
WO2008150495A2 (en) 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
US20170044545A1 (en) * 2014-04-24 2017-02-16 Ribomic Inc. Aptamer for bonding to autotaxin and inhibiting biological activity of autotaxin, and use for same
EP3266871B1 (en) * 2015-03-06 2021-04-28 TAGCyx Biotechnologies Inc. Method for stabilizing dna aptamers
AU2016346270A1 (en) 2015-10-30 2018-05-24 Tagcyx Biotechnologies DNA aptamer capable of bonding to vWF
US20230038761A1 (en) * 2020-02-04 2023-02-09 Band Therapeutics, Llc Regulation of von willebrand factor (vwf)
TW202237149A (zh) * 2020-11-24 2022-10-01 美商邦德治療公司 用於治療出血性障礙之組成物及方法
WO2023039522A1 (en) * 2021-09-10 2023-03-16 Guardian Therapeutics, Llc Fatty acid conjugates of nucleic acids

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20090170793A1 (en) * 2005-06-01 2009-07-02 Gaur Rajesh K Artificial riboswitch for controlling pre-mrna splicing
WO2010091396A2 (en) * 2009-02-09 2010-08-12 Archemix Corp. Aptamers to von willerbrand factor and their use as thrombotic, hematologic and cardiovascular disease therapeutics

Non-Patent Citations (1)

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Title
網路文獻 Oren Reinstein et al, "Engineering a structure switching mechanism into a steroid-binding aptamer and hydrodynamic analysis of the ligand binding mechanism.", Biochemistry. 2011 Nov 1;50(43): 9368-76. *

Also Published As

Publication number Publication date
KR20200008122A (ko) 2020-01-23
RU2019136508A3 (https=) 2022-02-14
CN110520128A (zh) 2019-11-29
TW201900877A (zh) 2019-01-01
US20260092283A1 (en) 2026-04-02
RU2019136508A (ru) 2021-06-22
JP2020522566A (ja) 2020-07-30
CN110520128B (zh) 2023-11-14
EP3624801A4 (en) 2021-02-24
CN117487811A (zh) 2024-02-02
IL269641B1 (en) 2024-08-01
AU2018269935A1 (en) 2019-11-28
KR102830459B1 (ko) 2025-07-09
JP2023093535A (ja) 2023-07-04
NZ758741A (en) 2025-09-26
IL269641A (en) 2019-11-28
US20200165612A1 (en) 2020-05-28
WO2018213697A1 (en) 2018-11-22
JP7781815B2 (ja) 2025-12-08
US11060094B2 (en) 2021-07-13
EP3624801A1 (en) 2020-03-25
CA3058001A1 (en) 2018-11-22
IL269641B2 (en) 2024-12-01
US20210292763A1 (en) 2021-09-23
JP7317805B2 (ja) 2023-07-31
MX2019013700A (es) 2020-01-15
MX390865B (es) 2025-03-12
AU2018269935B2 (en) 2024-05-16

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