JP7312451B2 - 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 - Google Patents
受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 Download PDFInfo
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- JP7312451B2 JP7312451B2 JP2019567188A JP2019567188A JP7312451B2 JP 7312451 B2 JP7312451 B2 JP 7312451B2 JP 2019567188 A JP2019567188 A JP 2019567188A JP 2019567188 A JP2019567188 A JP 2019567188A JP 7312451 B2 JP7312451 B2 JP 7312451B2
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022134818A JP7621664B2 (ja) | 2018-01-26 | 2022-08-26 | 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018011937 | 2018-01-26 | ||
| JP2018011937 | 2018-01-26 | ||
| PCT/JP2019/002504 WO2019146759A1 (ja) | 2018-01-26 | 2019-01-25 | 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022134818A Division JP7621664B2 (ja) | 2018-01-26 | 2022-08-26 | 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019146759A1 JPWO2019146759A1 (ja) | 2021-03-18 |
| JPWO2019146759A5 JPWO2019146759A5 (https=) | 2022-02-24 |
| JP7312451B2 true JP7312451B2 (ja) | 2023-07-21 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019567188A Active JP7312451B2 (ja) | 2018-01-26 | 2019-01-25 | 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 |
| JP2022134818A Active JP7621664B2 (ja) | 2018-01-26 | 2022-08-26 | 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2022134818A Active JP7621664B2 (ja) | 2018-01-26 | 2022-08-26 | 受容体タンパク質を標的とする治療薬、検査薬、受容体タンパク質に結合する抗体、及び分子標的薬のスクリーニング方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11773169B2 (https=) |
| EP (2) | EP3744346A4 (https=) |
| JP (2) | JP7312451B2 (https=) |
| CN (2) | CN112739380A (https=) |
| WO (1) | WO2019146759A1 (https=) |
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|---|---|---|---|---|
| CN114231635B (zh) * | 2021-12-31 | 2023-03-31 | 博尔诚(北京)科技有限公司 | 用于肺癌筛查的标志物、探针组合物及其应用 |
| CN118243808B (zh) * | 2024-02-05 | 2024-12-31 | 石家庄四药有限公司 | 一种np-01中有关物质的检测方法 |
| EP4635983A1 (en) | 2024-04-15 | 2025-10-22 | Ymmunobio AG | A novel antibody binding specifically to nptxr and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003533229A (ja) | 2000-05-12 | 2003-11-11 | バイオノミックス リミテッド | てんかんに関係する突然変異 |
| JP2010536366A (ja) | 2007-08-24 | 2010-12-02 | オンコセラピー・サイエンス株式会社 | 肺癌の治療及び診断の標的遺伝子のためのebi3、dlx5、nptx1、及びcdkn3 |
Family Cites Families (8)
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| US20050037445A1 (en) * | 2001-06-25 | 2005-02-17 | Poulsen Hans Skovgaard | Oncology drug innovation |
| JP2005501536A (ja) | 2001-07-18 | 2005-01-20 | バイオノミックス リミテッド | イオンチャネルにおける変異 |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US20090123940A1 (en) | 2007-10-12 | 2009-05-14 | The Johns Hopkins University | Molecules involved in synaptogenesis and uses therefor |
| CN102719522A (zh) * | 2011-03-31 | 2012-10-10 | 上海市肿瘤研究所 | 乙酰胆碱酯酶基因启动子用于抗肝癌药物的筛选 |
| WO2012153492A1 (en) | 2011-05-06 | 2012-11-15 | Oncotherapy Science, Inc. | Nptx2 as tumor marker and therapeutic target for cancer |
| JP2017511342A (ja) | 2014-04-04 | 2017-04-20 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 胃がんの処置 |
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2019
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- 2019-01-25 CN CN201980022443.1A patent/CN112739380A/zh active Pending
- 2019-01-25 EP EP19744055.5A patent/EP3744346A4/en active Pending
- 2019-01-25 WO PCT/JP2019/002504 patent/WO2019146759A1/ja not_active Ceased
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- 2019-01-25 EP EP22196119.6A patent/EP4169532A1/en active Pending
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003533229A (ja) | 2000-05-12 | 2003-11-11 | バイオノミックス リミテッド | てんかんに関係する突然変異 |
| JP2010536366A (ja) | 2007-08-24 | 2010-12-02 | オンコセラピー・サイエンス株式会社 | 肺癌の治療及び診断の標的遺伝子のためのebi3、dlx5、nptx1、及びcdkn3 |
Non-Patent Citations (2)
| Title |
|---|
| JONES IW. et al.,Presynaptic Localisation of the Nicotinic Acetylcholine Receptor β2 Subunit Immunoreactivity in Rat,THE JOURNAL OF COMPARATIVE NEUROLOGY,2001年,Vol.439,p.235-247 |
| STILL PC. et al.,Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities,JOURNAL OF NATURAL PRODUCTS,2013年,Vol.76,p.243-249 |
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| EP4169532A1 (en) | 2023-04-26 |
| EP3744346A4 (en) | 2022-04-20 |
| US12098205B2 (en) | 2024-09-24 |
| EP3744346A1 (en) | 2020-12-02 |
| WO2019146759A1 (ja) | 2019-08-01 |
| US11773169B2 (en) | 2023-10-03 |
| US20210040208A1 (en) | 2021-02-11 |
| US20240052041A1 (en) | 2024-02-15 |
| US20230081477A1 (en) | 2023-03-16 |
| CN116059349A (zh) | 2023-05-05 |
| CN112739380A (zh) | 2021-04-30 |
| US12129301B2 (en) | 2024-10-29 |
| JP7621664B2 (ja) | 2025-01-27 |
| JPWO2019146759A1 (ja) | 2021-03-18 |
| JP2022180377A (ja) | 2022-12-06 |
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