JP7304823B2 - 外科的に配置され中性子束により活性化される治療用高エネルギー荷電粒子発生システム - Google Patents
外科的に配置され中性子束により活性化される治療用高エネルギー荷電粒子発生システム Download PDFInfo
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- JP7304823B2 JP7304823B2 JP2019571991A JP2019571991A JP7304823B2 JP 7304823 B2 JP7304823 B2 JP 7304823B2 JP 2019571991 A JP2019571991 A JP 2019571991A JP 2019571991 A JP2019571991 A JP 2019571991A JP 7304823 B2 JP7304823 B2 JP 7304823B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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- Radiation-Therapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
従来式出願である本願は、2017年8月15日出願の米国仮特許出願第62/545,522号に基づく優先権を主張する。
Claims (8)
- 動物(12)の体内の局所化した癌細胞に適した治療線源物質(10)であって、
当該治療線源物質は水に溶解せず、無毒であり、さらに中性子照射場が形成されないときは実質的に非放射性であるが、所定の期間にわたり形成される所与の強さ以上の中性子照射場では電離作用は強いが透過性が低い放射線の線源となるものであり、
当該治療線源物質は非放射性の状態で当該動物の体内に埋め込まれ、当該動物の体外から中性子照射場が形成されることにより、当該電離作用は強いが透過性が低い放射線を発生するものであり、
当該治療線源物質はB-10濃度が濃縮されているB4CまたはP-31により構成され、
当該治療線源物質は、中性子を実質的に透過させるが当該電離作用の強い放射線の少なくとも一部を遮蔽する放射線遮蔽材が或る面に形成された、ミクロン単位の厚さを有する非常に薄いディスクまたはプレートの形をしている
ことを特徴とする治療線源物質。 - 請求項1の治療線源物質(10)と、
動物の体内に埋め込まれている当該治療線源物質(10)に中性子照射場を形成するための中性子発生装置アレイであって、中性子を当該治療線源物質(10)にさまざまな角度で照射するために身体の周囲に配置された複数の電気式中性子発生装置により構成されている、中性子発生装置アレイと
を含むシステム。 - 前記複数の電気式中性子発生装置(14)は複数のNeutristorである、請求項2のシステム。
- 前記治療線源物質(10)が発生する前記電離作用は強いが透過性が低い放射線を最適化するように中性子エネルギーを調節するために、前記電気式中性子発生装置(14)と前記治療線源物質(10)との間に中性子減速材(16)を含む、請求項2のシステム。
- 前記中性子減速材(16)はD2OまたはCを含む、請求項4のシステム。
- 前記治療線源物質への中性子照射による生成物が放出するガンマ線の強度を監視するガンマ線スペクトロメータ(18)を含むとともに、当該中性子照射時の荷電粒子の生成速度を監視できるようにする、請求項2のシステム。
- 前記ガンマ線強度および前記中性子照射場の中性子線強度を監視して身体が受けた放射線量を求める制御システム(20)を含む、請求項6のシステム。
- 前記制御システム(20)は前記監視されたガンマ線強度および前記放射線量に基づいて前記中性子照射場の強さを制御するように構成されている、請求項7のシステム。
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US201762545522P | 2017-08-15 | 2017-08-15 | |
US62/545,522 | 2017-08-15 | ||
PCT/US2018/046474 WO2019036355A2 (en) | 2017-08-15 | 2018-08-13 | SYSTEM FOR GENERATING HIGH ENERGY THERAPEUTIC CHARGED PARTICLES ACTIVATED BY A SURGICAL-POSITIONED NEUTRON STREAM |
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JP2020531059A JP2020531059A (ja) | 2020-11-05 |
JP7304823B2 true JP7304823B2 (ja) | 2023-07-07 |
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US (3) | US10603510B2 (ja) |
EP (1) | EP3668596B1 (ja) |
JP (1) | JP7304823B2 (ja) |
KR (1) | KR20200032200A (ja) |
CN (1) | CN110913953A (ja) |
AR (1) | AR112949A1 (ja) |
DK (1) | DK3668596T3 (ja) |
FI (1) | FI3668596T3 (ja) |
PT (1) | PT3668596T (ja) |
TW (1) | TWI778117B (ja) |
WO (1) | WO2019036355A2 (ja) |
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CN110913953A (zh) | 2017-08-15 | 2020-03-24 | 西屋电气有限责任公司 | 通过外科手术定位的中子通量激活的高能治疗带电粒子生成系统 |
KR20200111267A (ko) * | 2018-02-17 | 2020-09-28 | 웨스팅하우스 일렉트릭 컴퍼니 엘엘씨 | 암 치료를 위한 치료 이트륨-90의 직접적인 생성을 위한 시스템 |
AU2022226581A1 (en) | 2021-02-25 | 2023-09-14 | Westinghouse Electric Company Llc | Devices, systems, and methods for delivering delta radiation using prompt neutron capture gamma radiation |
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- 2018-08-13 US US16/102,063 patent/US10603510B2/en active Active
- 2018-08-13 EP EP18845617.2A patent/EP3668596B1/en active Active
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- 2018-08-13 KR KR1020207005918A patent/KR20200032200A/ko not_active Application Discontinuation
- 2018-08-13 DK DK18845617.2T patent/DK3668596T3/da active
- 2018-08-13 PT PT188456172T patent/PT3668596T/pt unknown
- 2018-08-13 WO PCT/US2018/046474 patent/WO2019036355A2/en unknown
- 2018-08-14 TW TW107128356A patent/TWI778117B/zh active
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US20190054313A1 (en) | 2019-02-21 |
DK3668596T3 (da) | 2024-02-05 |
JP2020531059A (ja) | 2020-11-05 |
US11260244B2 (en) | 2022-03-01 |
CN110913953A (zh) | 2020-03-24 |
US11794033B2 (en) | 2023-10-24 |
EP3668596A2 (en) | 2020-06-24 |
US20200188689A1 (en) | 2020-06-18 |
EP3668596A4 (en) | 2021-05-19 |
FI3668596T3 (fi) | 2024-01-30 |
TWI778117B (zh) | 2022-09-21 |
EP3668596B1 (en) | 2023-11-01 |
WO2019036355A2 (en) | 2019-02-21 |
RU2020110321A3 (ja) | 2022-01-20 |
TW201919732A (zh) | 2019-06-01 |
AR112949A1 (es) | 2020-01-08 |
US10603510B2 (en) | 2020-03-31 |
PT3668596T (pt) | 2024-02-05 |
US20220409925A1 (en) | 2022-12-29 |
KR20200032200A (ko) | 2020-03-25 |
RU2020110321A (ru) | 2021-09-16 |
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