JP2020531059A - 外科的に配置され中性子束により活性化される治療用高エネルギー荷電粒子発生システム - Google Patents
外科的に配置され中性子束により活性化される治療用高エネルギー荷電粒子発生システム Download PDFInfo
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Abstract
Description
従来式出願である本願は、2017年8月15日出願の米国仮特許出願第62/545,522号に基づく優先権を主張する。
Claims (20)
- 動物(12)の体内の局所化した癌細胞の治療方法であって、
所与の強さを下回る中性子照射場では実質的に非放射性であるが、所与の強さ以上の中性子照射場では電離作用は強いが透過性が低い放射線の線源となる治療線源(10)を体内の癌細胞の近傍に定置するステップと、
所定の期間にわたり体外から当該治療線源(10)に所与の強さ以上の中性子照射場を形成するステップとを含み、
当該照射場形成ステップを所定の間隔で繰り返すことを特徴とする方法。 - 前記電離作用は強いが透過性が低い放射線の前記治療線源(10)はB4CまたはP−31により構成される、請求項1の局所化した癌細胞の治療方法。
- 前記B4CはB−10濃度が濃縮されている、請求項2の局所化した癌細胞の治療方法。
- 前記電離作用は強いが透過性が低い放射線の前記治療線源(10)は実質的に前記癌細胞だけを照射するように構成されている、請求項1の局所化した癌細胞の治療方法。
- 中性子を実質的に透過させるが前記電離作用の強い放射線の少なくとも一部を遮蔽する放射線遮蔽材が、前記治療線源(10)の前記癌細胞とは反対側の面に形成されている、請求項4の局所化した癌細胞の治療方法。
- 前記定置ステップは、前記治療線源(10)を外科的に前記癌細胞に近接するように埋め込むステップを含む、請求項1の局所化した癌細胞の治療方法。
- 前記治療線源(10)に中性子照射場を形成するステップは、電気式中性子発生装置(14)により前記治療線源(10)に中性子を照射するステップを含む、請求項1の局所化した癌細胞の治療方法。
- 前記電気式中性子発生装置(14)はNeutristorである、請求項7の局所化した癌細胞の治療方法。
- 前記電気式中性子発生装置(14)は、中性子を前記治療線源(10)にさまざまな角度で照射するために身体の周囲に配置された複数の電気式中性子発生装置により構成されている、請求項7の局所化した癌細胞の治療方法。
- 前記治療線源(10)が発生する前記電離作用は強いが透過性が低い放射線を最適化するように中性子エネルギーを調節するために、前記電気式中性子発生装置(14)と前記治療線源(10)との間に中性子減速材(16)を使用するステップを含む、請求項7の局所化した癌細胞の治療方法。
- 前記中性子減速材(16)はD2OまたはCを含む、請求項10の局所化した癌細胞の治療方法。
- 前記中性子減速材(16)を使用するステップは、前記中性子減速材(16)を体外に配置するステップを含む、請求項10の局所化した癌細胞の治療方法。
- 前記局所化した癌細胞の治療の合間も前記治療線源(10)を体内に留置するステップを含む、請求項1の局所化した癌細胞の治療方法。
- 前記局所化した癌細胞の治療の完了後に前記治療線源(10)を体内から取り出すステップを含む、請求項13の局所化した癌細胞の治療方法。
- 前記治療線源(10)はミクロン単位の厚さを有する1つ以上の非常に薄いディスクまたはプレートにより構成され、前記治療線源(10)はさらに、当該1つ以上のディスクまたはプレートが当該癌細胞の周囲に定置されて中性子照射場に曝されると前記電離作用は強いが透過性が低い放射線が前記局所化した癌細胞の塊全体に影響を及ぼすのに十分な総合表面積を有することを特徴とする、請求項1の局所化した癌細胞の治療方法。
- 前記治療線源(10)は、高エネルギーのアルファまたはベータ粒子を発生させるがガンマ線は発生させない(発生させても低エネルギーのガンマ線)物質により構成されている、請求項1の局所化した癌細胞の治療方法。
- 前記治療線源物質は水に溶解せず、身体に対して無毒で、半減期が短い、請求項16の局所化した癌細胞の治療方法。
- 前記治療線源物質への中性子照射による生成物が放出するガンマ線の強度をガンマ線スペクトロメータ(18)により監視するとともに、当該中性子照射時の荷電粒子の生成速度を監視できるようにするステップを含む、請求項1の局所化した癌細胞の治療方法。
- 前記監視されたガンマ線強度および前記中性子場の中性子線強度から身体が受けた放射線量を求める、請求項18の局所化した癌細胞の治療方法。
- 前記監視されたガンマ線強度および前記放射線量に基づいて前記中性子場の強さを制御する、請求項19の局所化した癌細胞の治療方法。
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US201762545522P | 2017-08-15 | 2017-08-15 | |
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PCT/US2018/046474 WO2019036355A2 (en) | 2017-08-15 | 2018-08-13 | SYSTEM FOR GENERATING HIGH ENERGY THERAPEUTIC CHARGED PARTICLES ACTIVATED BY A SURGICAL-POSITIONED NEUTRON STREAM |
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CA3091420A1 (en) * | 2018-02-17 | 2020-02-20 | Westinghouse Electric Company Llc | System for the direct production of therapeutic yttrium-90 for cancer treatment |
WO2022183181A1 (en) | 2021-02-25 | 2022-09-01 | Westinghouse Electric Company Llc | Devices, systems, and methods for delivering delta radiation using prompt neutron capture gamma radiation |
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JP2014195505A (ja) * | 2013-03-29 | 2014-10-16 | 住友重機械工業株式会社 | 中性子捕捉療法装置 |
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AR112949A1 (es) | 2020-01-08 |
RU2020110321A3 (ja) | 2022-01-20 |
US10603510B2 (en) | 2020-03-31 |
EP3668596A2 (en) | 2020-06-24 |
JP7304823B2 (ja) | 2023-07-07 |
TW201919732A (zh) | 2019-06-01 |
PT3668596T (pt) | 2024-02-05 |
TWI778117B (zh) | 2022-09-21 |
US20220409925A1 (en) | 2022-12-29 |
US20200188689A1 (en) | 2020-06-18 |
KR20200032200A (ko) | 2020-03-25 |
US20190054313A1 (en) | 2019-02-21 |
DK3668596T3 (da) | 2024-02-05 |
EP3668596B1 (en) | 2023-11-01 |
WO2019036355A2 (en) | 2019-02-21 |
CN110913953A (zh) | 2020-03-24 |
US11794033B2 (en) | 2023-10-24 |
US11260244B2 (en) | 2022-03-01 |
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EP3668596A4 (en) | 2021-05-19 |
RU2020110321A (ru) | 2021-09-16 |
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