JP7296954B2 - ヒトｓｔｉｎｇの小分子調節因子 - Google Patents

ヒトｓｔｉｎｇの小分子調節因子 Download PDF

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JP7296954B2
JP7296954B2 JP2020520840A JP2020520840A JP7296954B2 JP 7296954 B2 JP7296954 B2 JP 7296954B2 JP 2020520840 A JP2020520840 A JP 2020520840A JP 2020520840 A JP2020520840 A JP 2020520840A JP 7296954 B2 JP7296954 B2 JP 7296954B2
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oxo
carboxamide
trifluorobenzyl
tetrahydroquinazoline
dimethyl
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JP2020524719A (ja
JP2020524719A5 (enExample
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モナリ・バナジー
サンディプ・ミドヤ
スーラヴ・バス
ラジブ・ゴーシュ
デイビッド・プライド
ダルメンドラ・ヤダヴ
リテシュ・シュリヴァスタヴァ
アルジュン・スルヤ
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Curadev Pharma Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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    • A61K31/66—Phosphorus compounds
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020520840A 2017-06-22 2018-06-21 ヒトｓｔｉｎｇの小分子調節因子 Active JP7296954B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1709959.9 2017-06-22
GB1709959.9A GB2563642A (en) 2017-06-22 2017-06-22 Small molecule modulators of human STING
IN201711021858 2017-06-22
IN201711021858 2017-06-22
IN201811014462 2018-04-16
IN201811014462 2018-04-16
PCT/GB2018/051730 WO2018234808A1 (en) 2017-06-22 2018-06-21 Small molecule modulators of human sting

Publications (3)

Publication Number Publication Date
JP2020524719A JP2020524719A (ja) 2020-08-20
JP2020524719A5 JP2020524719A5 (enExample) 2021-07-26
JP7296954B2 true JP7296954B2 (ja) 2023-06-23

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JP2020520840A Active JP7296954B2 (ja) 2017-06-22 2018-06-21 ヒトｓｔｉｎｇの小分子調節因子

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US (1) US11571423B2 (enExample)
EP (1) EP3642198B1 (enExample)
JP (1) JP7296954B2 (enExample)
KR (1) KR102628892B1 (enExample)
CN (1) CN111132972B (enExample)
AR (1) AR114975A1 (enExample)
AU (1) AU2018288018C1 (enExample)
CA (1) CA3067257A1 (enExample)
CL (1) CL2019003793A1 (enExample)
CO (1) CO2020000562A2 (enExample)
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IL (1) IL271522B2 (enExample)
MX (1) MX2019015468A (enExample)
PE (1) PE20200696A1 (enExample)
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UA (1) UA125730C2 (enExample)
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GB2574913A (en) * 2017-06-22 2019-12-25 Curadev Pharma Ltd Small molecule modulators of human STING, conjugates and therapeutic applications
EP3642198B1 (en) 2017-06-22 2022-03-16 Curadev Pharma Limited Small molecule modulators of human sting
WO2019046511A1 (en) 2017-08-31 2019-03-07 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
WO2019051489A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
WO2019051488A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
WO2019178129A1 (en) 2018-03-13 2019-09-19 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
WO2019227007A1 (en) 2018-05-25 2019-11-28 Incyte Corporation Tricyclic heterocyclic compounds as sting activators
WO2020014127A1 (en) 2018-07-10 2020-01-16 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
WO2020028566A1 (en) 2018-07-31 2020-02-06 Incyte Corporation Heteroaryl amide compounds as sting activators
WO2020028565A1 (en) 2018-07-31 2020-02-06 Incyte Corporation Tricyclic heteraryl compounds as sting activators
US11596692B1 (en) 2018-11-21 2023-03-07 Incyte Corporation PD-L1/STING conjugates and methods of use
US12129267B2 (en) 2019-01-07 2024-10-29 Incyte Corporation Heteroaryl amide compounds as sting activators
US20220144852A1 (en) 2019-03-28 2022-05-12 Lupin Limited Macrocyclic compounds as sting agonists
JP7531508B2 (ja) 2019-04-30 2024-08-09 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド ベンゾチオフェン化合物、その調製方法およびその使用
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
EP3983078B1 (en) * 2019-06-12 2023-11-15 Ryvu Therapeutics S.A. Next-generation modulators of stimulator of interferon genes (sting)
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