JP7284556B2 - T細胞療法によるエプスタイン-バーウイルス関連リンパ増殖性障害の治療方法 - Google Patents

T細胞療法によるエプスタイン-バーウイルス関連リンパ増殖性障害の治療方法 Download PDF

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JP7284556B2
JP7284556B2 JP2017559029A JP2017559029A JP7284556B2 JP 7284556 B2 JP7284556 B2 JP 7284556B2 JP 2017559029 A JP2017559029 A JP 2017559029A JP 2017559029 A JP2017559029 A JP 2017559029A JP 7284556 B2 JP7284556 B2 JP 7284556B2
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ジョン オレイリ リチャード
エリザベス プロコプ スーザン
ナスリーン ハサン アイシャ
ドウブロビナ エカテリーナ
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メモリアル スローン ケタリング キャンサー センター
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/50Cellular immunotherapy characterised by the use of allogeneic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017559029A 2015-05-12 2016-05-11 T細胞療法によるエプスタイン-バーウイルス関連リンパ増殖性障害の治療方法 Active JP7284556B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021070234A JP2021119154A (ja) 2015-05-12 2021-04-19 T細胞療法によるエプスタイン−バーウイルス関連リンパ増殖性障害の治療方法

Applications Claiming Priority (3)

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US201562160549P 2015-05-12 2015-05-12
US62/160,549 2015-05-12
PCT/US2016/031784 WO2016183153A1 (en) 2015-05-12 2016-05-11 Methods of treating epstein-barr virus-associated lymphoproliferative disorders by t cell therapy

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JP2021070234A Division JP2021119154A (ja) 2015-05-12 2021-04-19 T細胞療法によるエプスタイン−バーウイルス関連リンパ増殖性障害の治療方法

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JP2018520095A JP2018520095A (ja) 2018-07-26
JP2018520095A5 JP2018520095A5 (https=) 2019-11-14
JP7284556B2 true JP7284556B2 (ja) 2023-05-31

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JP2017559029A Active JP7284556B2 (ja) 2015-05-12 2016-05-11 T細胞療法によるエプスタイン-バーウイルス関連リンパ増殖性障害の治療方法
JP2021070234A Pending JP2021119154A (ja) 2015-05-12 2021-04-19 T細胞療法によるエプスタイン−バーウイルス関連リンパ増殖性障害の治療方法

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US (1) US10568908B2 (https=)
EP (1) EP3294304B1 (https=)
JP (2) JP7284556B2 (https=)
KR (1) KR102666781B1 (https=)
CN (1) CN107835690A (https=)
AR (1) AR104598A1 (https=)
AU (1) AU2016262484B2 (https=)
BR (1) BR112017024431B1 (https=)
CA (1) CA2984178C (https=)
CL (1) CL2017002846A1 (https=)
FR (1) FR23C1025I2 (https=)
IL (1) IL255581B (https=)
MX (1) MX386334B (https=)
NZ (1) NZ736675A (https=)
PH (1) PH12017501993A1 (https=)
RU (1) RU2720245C2 (https=)
WO (1) WO2016183153A1 (https=)
ZA (1) ZA201707335B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ749136A (en) 2016-05-25 2023-11-24 Council Queensland Inst Medical Res Methods of immunotherapy
AU2017326173B2 (en) * 2016-09-16 2022-08-18 Baylor College Of Medicine Platform for activation and expansion of virus-specific T-cells
AU2018355145A1 (en) * 2017-10-23 2020-04-30 Atara Biotherapeutics, Inc. Methods of managing tumor flare in adoptive immunotherapy
CN108220237B (zh) * 2017-12-20 2020-11-06 中国科学院遗传与发育生物学研究所 一种人的nk/t细胞系
US20200350049A1 (en) * 2018-01-08 2020-11-05 Atara Biotherapeutics, Inc. Systems and methods for distributing cell therapies
US20210000874A1 (en) 2018-03-14 2021-01-07 Memorial Sloan Kettering Cancer Center Methods of selecting t cell line for adoptive cellular therapy
JP2022554217A (ja) * 2019-10-23 2022-12-28 ザ・カウンシル・オヴ・ザ・クイーンズランド・インスティテュート・オヴ・メディカル・リサーチ 養子免疫療法
CN118256604B (zh) * 2024-04-16 2024-11-19 华中科技大学 一种利用人工抗原呈递细胞进行免疫原性肿瘤新抗原筛选与鉴定方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO784197A0 (en) * 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
US7163685B2 (en) * 2003-04-16 2007-01-16 City Of Hope Human cytomegalovirus antigens expressed in MVA and methods of use
JP4824389B2 (ja) * 2005-10-28 2011-11-30 株式会社医学生物学研究所 エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途
EP2365823B1 (en) 2008-10-30 2016-11-30 Yeda Research And Development Company Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
AU2011295845B2 (en) 2010-09-01 2016-09-22 Baylor College Of Medicine EBV-specific cytotoxic T-lymphocytes for the treatment of locoregional nasopharyngeal carcinoma (NPC)
EP3144008B1 (en) * 2012-05-08 2018-01-17 The John Hopkins University Compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes
CA2889064A1 (en) * 2012-10-19 2014-04-24 The Council Of The Queensland Institute Of Medical Research Improved human herpesvirus immunotherapy
JP2016539929A (ja) * 2013-10-25 2016-12-22 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 免疫療法のためのポリクローナルγδT細胞
MY189857A (en) * 2014-11-05 2022-03-14 Memorial Sloan Kettering Cancer Center Methods of selecting t cell line and donor thereof for adoptive cellular therapy
WO2017003763A1 (en) * 2015-06-27 2017-01-05 Memorial Sloan Kettering Cancer Center Methods of treating glioblastoma multiforme by t cell therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GANDHI M K,AMERICAN JOURNAL OF TRANSPLANTATION,2007年 5月,VOL:7,NR:5,PAGE(S):1293 - 1299,URL,http://dx.doi.org/10.1111/j.1600-6143.2007.01796.x
HAQUE T,THE LANCET,英国,THE LANCET PUBLISHING GROUP,2002年8月10日,VOL:360, NR:9331,PAGE(S):436 - 442,URL,http://dx.doi.org/10.1016/S0140-6736(02)09672-1

Also Published As

Publication number Publication date
MX2017014257A (es) 2018-04-20
US10568908B2 (en) 2020-02-25
CN107835690A (zh) 2018-03-23
CA2984178C (en) 2023-10-31
BR112017024431B1 (pt) 2021-10-13
KR102666781B1 (ko) 2024-05-20
MX386334B (es) 2025-03-18
US20180125891A1 (en) 2018-05-10
RU2017143151A (ru) 2019-06-13
HK1244697A1 (en) 2018-08-17
JP2018520095A (ja) 2018-07-26
EP3294304A1 (en) 2018-03-21
CL2017002846A1 (es) 2018-05-25
RU2720245C2 (ru) 2020-04-28
AR104598A1 (es) 2017-08-02
ZA201707335B (en) 2021-02-24
IL255581B (en) 2021-03-25
KR20180003575A (ko) 2018-01-09
JP2021119154A (ja) 2021-08-12
RU2017143151A3 (https=) 2019-10-29
AU2016262484A1 (en) 2018-01-04
NZ736675A (en) 2023-03-31
IL255581A (en) 2018-01-31
CA2984178A1 (en) 2016-11-17
AU2016262484B2 (en) 2021-10-21
PH12017501993A1 (en) 2018-03-26
WO2016183153A1 (en) 2016-11-17
FR23C1025I1 (fr) 2023-07-21
EP3294304B1 (en) 2020-01-29
FR23C1025I2 (fr) 2025-04-18
BR112017024431A2 (pt) 2018-07-24

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