JP7275031B2 - Stingアゴニストとしての環状ジヌクレオチド - Google Patents

Stingアゴニストとしての環状ジヌクレオチド Download PDF

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JP7275031B2
JP7275031B2 JP2019540518A JP2019540518A JP7275031B2 JP 7275031 B2 JP7275031 B2 JP 7275031B2 JP 2019540518 A JP2019540518 A JP 2019540518A JP 2019540518 A JP2019540518 A JP 2019540518A JP 7275031 B2 JP7275031 B2 JP 7275031B2
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pharmaceutically acceptable
mixture
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JP2020505405A5 (enExample
JP2020505405A (ja
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エマニュエル,スチュアート
リクター,マーク
ジェィ. コノリー,ピーター
パトリック エドワーズ,ジェームズ
ワン,グァンジ
クマール サチコンダ,サントーシュ
ビーゲルマン,レオニド
ジョン,ミンホン
ビグナン,ギルス
シェペンス,ウィム
ヴィエルヴォイェ,マルセル
ウィスヘルムス ジョン フィッツジェラルド シューリン,ジョハネス
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ヤンセン バイオテツク,インコーポレーテツド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019540518A 2017-01-27 2018-01-26 Stingアゴニストとしての環状ジヌクレオチド Active JP7275031B2 (ja)

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JP2022137667A JP2022180398A (ja) 2017-01-27 2022-08-31 Stingアゴニストとしての環状ジヌクレオチド

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US201762451301P 2017-01-27 2017-01-27
US201762451351P 2017-01-27 2017-01-27
US62/451,301 2017-01-27
US62/451,351 2017-01-27
US201762454135P 2017-02-03 2017-02-03
US62/454,135 2017-02-03
PCT/IB2018/050498 WO2018138685A2 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as sting agonists

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JP2020505405A JP2020505405A (ja) 2020-02-20
JP2020505405A5 JP2020505405A5 (enExample) 2021-03-04
JP7275031B2 true JP7275031B2 (ja) 2023-05-17

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JP2022137667A Pending JP2022180398A (ja) 2017-01-27 2022-08-31 Stingアゴニストとしての環状ジヌクレオチド

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US (2) US11492367B2 (enExample)
EP (1) EP3573718B1 (enExample)
JP (2) JP7275031B2 (enExample)
CN (1) CN110234403A (enExample)
AU (1) AU2018212788A1 (enExample)
ES (1) ES2924186T3 (enExample)
WO (1) WO2018138685A2 (enExample)

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EP3993834A1 (en) 2019-07-05 2022-05-11 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
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AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
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CN112321589B (zh) * 2020-02-18 2022-05-03 山东科巢生物制药有限公司 一种抗病毒药物瑞德西韦及其中间体的合成方法
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
US11179473B2 (en) 2020-02-21 2021-11-23 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
JPWO2021206158A1 (enExample) 2020-04-10 2021-10-14
EP4168421A1 (en) 2020-06-22 2023-04-26 Illumina Cambridge Limited Nucleosides and nucleotides with 3' acetal blocking group
CN116209678A (zh) 2020-07-01 2023-06-02 安尔士制药公司 抗asgr1抗体缀合物及其用途
US20230256109A1 (en) 2020-08-07 2023-08-17 Tambo, Inc. Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy
TW202233251A (zh) 2020-11-09 2022-09-01 日商武田藥品工業股份有限公司 抗體藥物綴合物
KR20230170745A (ko) 2021-04-16 2023-12-19 길리애드 사이언시즈, 인코포레이티드 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법
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Publication number Publication date
US11492367B2 (en) 2022-11-08
WO2018138685A2 (en) 2018-08-02
EP3573718B1 (en) 2022-06-01
WO2018138685A3 (en) 2018-10-04
EP3573718A2 (en) 2019-12-04
ES2924186T3 (es) 2022-10-05
AU2018212788A1 (en) 2019-07-25
JP2022180398A (ja) 2022-12-06
CN110234403A (zh) 2019-09-13
US20190375782A1 (en) 2019-12-12
US20230146410A1 (en) 2023-05-11
JP2020505405A (ja) 2020-02-20

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