JP7274421B2 - らせん形状および起伏平面幾何学形状を有する骨接触要素を備えるインプラント - Google Patents
らせん形状および起伏平面幾何学形状を有する骨接触要素を備えるインプラント Download PDFInfo
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- JP7274421B2 JP7274421B2 JP2019550216A JP2019550216A JP7274421B2 JP 7274421 B2 JP7274421 B2 JP 7274421B2 JP 2019550216 A JP2019550216 A JP 2019550216A JP 2019550216 A JP2019550216 A JP 2019550216A JP 7274421 B2 JP7274421 B2 JP 7274421B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30112—Rounded shapes, e.g. with rounded corners
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4629—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof connected to the endoprosthesis or implant via a threaded connection
Description
図1は、インプラント100の一実施形態の模式図である。説明の都合上、インプラント100は、脊柱101の部分に隣接して示される。図2では、インプラント100の実施形態は、脊柱101内の2つの隣接する椎骨(椎骨192および椎骨194)間への挿入後の状態が示されている。この挿入は、図1および図2に模式的に示される挿入ツール105の使用によって容易にされる。
明確にするために、詳細な説明および特許請求の範囲において方向を示す種々の形容詞に言及する。本明細書において用いられる場合、「前方」という用語は、インプラントを体内に置いたときに人体の前面の方に向けられることが意図される、インプラントの側部または部分を指す。同様に、「後方」という用語は、埋め込み後に人体の背面の方に向けられることが意図される、インプラントの側部または部分を指す。また、「上側」という用語は、体の上部(例、頭)の方に向けられることが意図されるインプラントの側部または部分を指すのに対し、「下側」は、体の底部の方に向けられることが意図されるインプラントの側部または部分を指す。本明細書において、インプラントの「外側」側部または部分にも言及するが、これは、埋め込み後に体の外側方向に面する側部または部分である。
実施形態は、インプラントの骨接触要素に沿った、また、インプラントに隣接した、骨成長を保護するための手段を含むことができる。いくつかの実施形態では、骨接触要素は、「被保護癒合ゾーン」と称されてもよい選択された領域における新たな骨成長の保護を助ける幾何学形状で構成することができる。被保護癒合ゾーンにおいて、新たな骨の成長は、椎骨とインプラントの骨接触面との間で直接伝達される力から部分的に保護され、それにより、新たな骨の成長がインプラントを介して伝搬するであろう速度を増加させるであろう。
実施形態は、移植片用のインプラント内およびその周りの利用可能な容量を最大にしながらインプラントに強度を提供するための手段を含むことができる。いくつかの実施形態は、利用可能な被保護癒合ゾーンの数を増やしながらインプラント全体の支持を増大させる構成で配置される略らせん形骨接触要素を使用することができるであろう。
異なる実施形態において、骨接触要素は、さまざまな方法で互いに接続されてもよい。図10は、骨接触要素間の接続のいくつかの異なるタイプの模式図である。図10でわかるように、1つの例示的なタイプの接続550では、1つの骨接触要素551の端部は、別の骨接触要素552に接続されてもよい。別の例示的なタイプの接続560では、2つの骨接触要素(すなわち、要素561および要素562)が、互いを介して、または互いを横切って通過するように交差してもよい。さらに別の例示的なタイプの接続570では、骨接触要素571および骨接触要素572は、接線方向接続を形成してもよく、そこでは、該要素がその側壁に沿って接触するのみである。
実施形態は、インプラントの1つ以上の表面をテクスチャ加工するための手段を含むことができる。このようなテクスチャ加工は、インプラントの表面への骨成長および/または癒合を増加または別様に促進することができる。いくつかの実施形態では、骨接触要素および/またはボディのセクションがテクスチャ加工されてもよい。
実施形態は、隣接する椎骨によって印加される垂直方向負荷などのさまざまな負荷にさらによく耐えるために、1つ以上の方向にインプラントの強度を修正するための手段を含むことができる。いくつかの実施形態では、1つ以上の骨接触要素の形状および/またはサイズを、1つ以上の側においておよび/または1つ以上の方向に沿ってインプラントの強度を変えるために修正することができる。他の実施形態では、追加の支持構造を、1つ以上の側部を補強するためにインプラント内に組み込むことができる。いくつかの場合では、たとえば、実施形態は、たとえばインプラントの外側側部に、1つ以上の骨接触要素と交差してもよい1つ以上の支持壁を組み込むことができるであろう。
いくつかの実施形態では、骨成長は、インプラントの一部内またはインプラントの周囲に骨成長促進材料を適用することによって促進することができる。本明細書で用いられる場合、「骨成長促進材料」(またはBGPM)とは、骨の成長を助ける任意の材料である。骨成長促進材料は、リンカー分子またはバインダの使用により表面に凍結乾燥されるかまたは金属に付着される手段を含んでもよい。骨成長促進材料の例は、BMP-1、BMP-2、BMP-4、BMP-6およびBMP-7等の骨形成タンパク質(BMP)を含む、任意の材料である。これらは、幹細胞を骨形成細胞に変換するホルモンである。別の例には、rhBMP-2、rhBMP-4およびrhBMP-7等のリコンビナントヒトBMP(rhBMP)が挙げられる。さらに別の例には、血小板由来増殖因子(PDGF)、線維芽細胞増殖因子(FGF)、コラーゲン、BMP模倣ペプチド、およびRGDペプチドが挙げられる。一般に、これらの化学物質の組み合わせも使用してもよい。これらの化学物質は、スポンジ、基質またはゲルを使用して塗布することができる。
〈製造工程と材料〉
インプラントの種々の構成要素は、特定の用途および/または医師による選択に応じて、金属(たとえば、チタンまたは他の金属)、セラミック、および/またはそれらの組み合わせを含むがこれらに限定されない、人体に埋め込むのに好適な生体適合性材料から製造されてもよい。
本発明の精神および範囲は、添付する特許請求の範囲の中に存在するが、本願の特許請求の範囲として存在し、その一部は補正により削除された、以下の[予備的な特許請求の範囲]の中にも潜在する。この[予備的な特許請求の範囲]の記載事項は、本願明細書の開示に含まれるものとする。
[予備的な特許請求の範囲]
[予備請求項10]
インプラントであって、
第1本体部材および第2本体部材と、
前記第1本体部材から前記第2本体部材に延びている骨接触要素と
を含み、
前記骨接触要素は、起伏平面幾何学形状を有する、インプラント。
[予備請求項11]
前記インプラントは、略らせん形幾何学形状を有する少なくとも1つの骨接触要素をさらに含む、予備請求項10に記載のインプラント。
[予備請求項12]
前記骨接触要素は、前記インプラントを上側半体と下側半体に分ける横断面と交差している、予備請求項10に記載のインプラント。
[予備請求項13]
前記骨接触要素は、第1略らせん形骨接触要素と第2略らせん形骨接触要素との間に配置されている、予備請求項10に記載のインプラント。
[予備請求項14]
前記骨接触要素は、円形断面形状を有する、予備請求項10に記載のインプラント。
[予備請求項15]
前記骨接触要素は、矩形断面形状を有する、予備請求項10に記載のインプラント。
[予備請求項16]
前記骨接触要素の中央湾曲部が、前記起伏平面幾何学形状を有する、予備請求項10に記載のインプラント。
[予備請求項17]
前記骨接触要素の外面湾曲部が、前記起伏平面幾何学形状を有する、予備請求項10に記載のインプラント。
[予備請求項18]
インプラントであって、
上方側部、下方側部および外側側部と、
第1本体部材および第2本体部材と、
前記第1本体部材から前記第2本体部材に延びている第1骨接触要素であって、前記第1骨接触要素は、前記外側側部が前記上方側部と接触する位置に隣接して配置されている、第1骨接触要素と、
前記第1本体部材から前記第2本体部材に延びている第2骨接触要素であって、前記第2骨接触要素は、前記外側側部が前記下方側部と接触する位置に隣接して配置されている、第2骨接触要素と、
前記外側側部において前記第1骨接触要素と前記第2骨接触要素との間を延びている支持壁と、
前記支持壁と交差している第3骨接触要素と
を含む、インプラント。
[予備請求項19]
前記第3骨接触要素は、起伏平面幾何学形状を有する、予備請求項18に記載のインプラント。
[予備請求項20]
前記支持壁との前記第3骨接触要素の交差部は、前記第1骨接触要素と前記第2骨接触要素との間で第1隆起骨接触領域および第2隆起骨接触領域を形成する、予備請求項19に記載のインプラント。
[予備請求項21]
インプラントであって、
第1本体部材および第2本体部材と、
前記第1本体部材から前記第2本体部材に延びる第1方向、および、前記第1方向と直交する第2方向と、
前記第2方向に沿って大略的に延びている中央骨接触要素と
を含み、
前記中央骨接触要素は、起伏平面幾何学形状を有する、インプラント。
[予備請求項22]
前記第1本体部材は、前記インプラントの前方側部に配置され、前記第2本体部材は、前記インプラントの後方側部に配置されている、予備請求項21に記載のインプラント。
[予備請求項23]
前記インプラントは、前記インプラントの第1外側側部において前記第1本体部材から前記第2本体部材に延びている第1外周骨接触要素を含む、予備請求項21に記載のインプラ
ント。
[予備請求項24]
前記インプラントは、前記インプラントの第2外側側部において前記第1本体部材から前記第2本体部材に延びている第2外周骨接触要素を含む、予備請求項23に記載のインプラント。
[予備請求項25]
前記中央骨接触要素は、前記第1外周骨接触要素から前記第2外周骨接触要素に延びている、予備請求項24に記載のインプラント。
[予備請求項26]
前記第1外周骨接触要素は、起伏平面幾何学形状を有する、予備請求項25に記載のインプラント。
[予備請求項27]
前記インプラントは、前記第1本体部材から前記第2本体部材に延びている上方骨接触要素を含み、前記上方骨接触要素は、前記中央骨接触要素に取り付けられている、予備請求項21に記載のインプラント。
[予備請求項28]
前記上方骨接触要素は、一般的ならせん形幾何学形状を有する、予備請求項27に記載のインプラント。
[予備請求項29]
前記上方骨接触要素の部分は、前記中央骨接触要素の部分と整列される、予備請求項28に記載のインプラント。
Claims (8)
- インプラントであって、
前記インプラントの前方端部に配置された第1本体部材と、
前記インプラントの後方端部に配置された第2本体部材と、
前記第1本体部材から前記第2本体部材に延び、第1側壁を有する第1骨接触要素と、
前記第1本体部材から前記第2本体部材に延び、第2側壁を有する第2骨接触要素と
を含み、
前記第1骨接触要素の前記第1側壁は、接続部において前記第2骨接触要素の前記第2側壁に接触している、インプラント。 - 前記第1骨接触要素は、前記接続部において前記第2骨接触要素に対して接線方向に沿って接触している、請求項1に記載のインプラント。
- 前記第1骨接触要素は、略らせん形幾何学形状を有する、請求項1に記載のインプラント。
- 前記第2骨接触要素は、略らせん形幾何学形状を有する、請求項3に記載のインプラント。
- 前記第2骨接触要素は、起伏平面幾何学形状を有する、請求項3に記載のインプラント。
- 前記第1骨接触要素および前記第2骨接触要素は、前記インプラントを右側半体および左側半体に分ける正中面に隣接して配置されている、請求項1または請求項4に記載のインプラント。
- 前記第1骨接触要素は、前記第2骨接触要素よりも大きな巻径を有する、請求項4に記載のインプラント。
- 前記インプラントは下方側部および上方側部を含み、
前記インプラントは、前記上方側部において略らせん形幾何学形状を有する少なくとも6つの骨接触要素を含み、
前記インプラントは、前記下方側部において略らせん形幾何学形状を有する少なくとも6つの骨接触要素を含み、
前記上方側部および前記下方側部の前記骨接触要素のそれぞれは、前記第1本体部材から前記第2本体部材に延びている、請求項1に記載のインプラント。
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US15/457,515 US10357377B2 (en) | 2017-03-13 | 2017-03-13 | Implant with bone contacting elements having helical and undulating planar geometries |
PCT/US2018/022021 WO2018169871A1 (en) | 2017-03-13 | 2018-03-12 | Implant with bone contacting elements having helical and undulating planar geometries |
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US20220047398A1 (en) | 2022-02-17 |
US11160668B2 (en) | 2021-11-02 |
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WO2018169871A1 (en) | 2018-09-20 |
US10357377B2 (en) | 2019-07-23 |
JP2020509864A (ja) | 2020-04-02 |
BR112019018976A2 (pt) | 2020-04-28 |
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