JP7273791B2 - 腫瘍成長を阻害するＣＨＫ１（ＳＲＡ７３７）／ＰＡＲＰｉ組み合わせ方法 - Google Patents

腫瘍成長を阻害するＣＨＫ１（ＳＲＡ７３７）／ＰＡＲＰｉ組み合わせ方法 Download PDF

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JP7273791B2
JP7273791B2 JP2020506298A JP2020506298A JP7273791B2 JP 7273791 B2 JP7273791 B2 JP 7273791B2 JP 2020506298 A JP2020506298 A JP 2020506298A JP 2020506298 A JP2020506298 A JP 2020506298A JP 7273791 B2 JP7273791 B2 JP 7273791B2
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cancer
parpi
sra737
combination
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JP2020516693A (ja
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クリスチャン アンドリュー ハシッグ，
ブライアン ウィリアム ストラウス，
ライアン ジェイムズ ハンセン，
ケナ リン アンデレス，
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シエラ オンコロジー， インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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JP2020506298A 2017-04-10 2018-04-10 腫瘍成長を阻害するＣＨＫ１（ＳＲＡ７３７）／ＰＡＲＰｉ組み合わせ方法 Active JP7273791B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762483888P 2017-04-10 2017-04-10
US62/483,888 2017-04-10
US201762552364P 2017-08-30 2017-08-30
US62/552,364 2017-08-30
US201862614268P 2018-01-05 2018-01-05
US62/614,268 2018-01-05
US201862635394P 2018-02-26 2018-02-26
US62/635,394 2018-02-26
US201862650185P 2018-03-29 2018-03-29
US62/650,185 2018-03-29
PCT/US2018/026917 WO2018191277A1 (en) 2017-04-10 2018-04-10 Chk1 (sra737)/parpi combination methods of inhibiting tumor growth

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JP2020516693A5 JP2020516693A5 (https=) 2021-03-25
JP7273791B2 true JP7273791B2 (ja) 2023-05-15

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KR (1) KR102645511B1 (https=)
CN (2) CN110582490A (https=)
AU (2) AU2018250552B2 (https=)
CA (1) CA3059576A1 (https=)
MX (1) MX2019012176A (https=)
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CA3092079A1 (en) * 2018-02-26 2019-08-29 Sierra Oncology, Inc. Methods of treatment of cancer comprising chk1 inhibitors
WO2020198510A1 (en) * 2019-03-28 2020-10-01 Sierra Oncology, Inc. Methods of treating cancer with chk1 inhibitors
US20220226338A1 (en) * 2019-05-14 2022-07-21 Sierra Oncology, Inc. Methods of Treating Cancer Using CHK1 Inhibitors
KR102285996B1 (ko) * 2019-08-08 2021-08-05 차의과학대학교 산학협력단 혈관신생을 억제하는 데 사용하기 위한 조성물 및 그 용도
EP4087563A4 (en) * 2020-01-07 2024-03-27 Shanghai Huayu Biotechnology Co., Ltd. COMBINATION CANCER THERAPY WITH CHK INHIBITOR
TW202204348A (zh) 2020-04-07 2022-02-01 美商西爾拉癌症醫學公司 Ｃｈｋ１抑制劑之合成方法
AU2021325905A1 (en) 2020-08-12 2023-04-13 Boundless Bio, Inc. Replication stress pathway agent compositions and methods for treating cancer
KR20230146593A (ko) * 2021-02-16 2023-10-19 리본 테라퓨틱스 인코포레이티드 Parp7 억제제에 대한 투여량 레지멘

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CN110582490A (zh) 2019-12-17
CN116999564A (zh) 2023-11-07
US11596637B2 (en) 2023-03-07
MX2019012176A (es) 2020-02-19
KR20200009004A (ko) 2020-01-29
JP2020516693A (ja) 2020-06-11
EP3609884A4 (en) 2021-01-06
EP3609884A1 (en) 2020-02-19
AU2022259818A1 (en) 2022-12-01
US20210077499A1 (en) 2021-03-18
AU2018250552A1 (en) 2019-11-14
AU2018250552B2 (en) 2022-08-04
WO2018191277A1 (en) 2018-10-18
CA3059576A1 (en) 2018-10-18
KR102645511B1 (ko) 2024-03-08

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