JP7269182B2 - 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法 - Google Patents

心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法 Download PDF

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JP7269182B2
JP7269182B2 JP2019565410A JP2019565410A JP7269182B2 JP 7269182 B2 JP7269182 B2 JP 7269182B2 JP 2019565410 A JP2019565410 A JP 2019565410A JP 2019565410 A JP2019565410 A JP 2019565410A JP 7269182 B2 JP7269182 B2 JP 7269182B2
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マクイストン，ベス
コーレイ，フレドリック
ベシリ，アギム
マリノ，ジェイミー
ダトワイラー，ソール
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    • A—HUMAN NECESSITIES
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    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
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    • A61B5/4064—Evaluating the brain
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019565410A 2017-05-30 2018-05-30 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法 Active JP7269182B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762512688P 2017-05-30 2017-05-30
US201762512710P 2017-05-30 2017-05-30
US62/512,710 2017-05-30
US62/512,688 2017-05-30
US201762528214P 2017-07-03 2017-07-03
US62/528,214 2017-07-03
PCT/US2018/035231 WO2018222783A1 (en) 2017-05-30 2018-05-30 Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers

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JP2020522685A JP2020522685A (ja) 2020-07-30
JP2020522685A5 JP2020522685A5 (https=) 2020-12-10
JP7269182B2 true JP7269182B2 (ja) 2023-05-08

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JP2019565417A Active JP7269183B2 (ja) 2017-05-30 2018-05-30 心臓トロポニンｉを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法

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US (6) US11129564B2 (https=)
EP (2) EP3631467A1 (https=)
JP (2) JP7269182B2 (https=)
CN (2) CN110709704B (https=)
AU (2) AU2018275236B2 (https=)
BR (2) BR112019025313A2 (https=)
WO (2) WO2018222784A1 (https=)

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JP5781436B2 (ja) * 2008-08-11 2015-09-24 バンヤン・バイオマーカーズ・インコーポレーテッド 神経学的状態のバイオマーカー検出方法およびアッセイ
US12601749B2 (en) 2008-08-11 2026-04-14 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
CA3261113A1 (en) 2017-03-23 2025-10-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
WO2018191531A1 (en) 2017-04-15 2018-10-18 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
ES3053676T3 (en) 2017-04-28 2026-01-23 Abbott Lab Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US10866251B2 (en) 2017-05-25 2020-12-15 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
JP7269182B2 (ja) 2017-05-30 2023-05-08 アボット・ラボラトリーズ 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法
US11169159B2 (en) 2017-07-03 2021-11-09 Abbott Laboratories Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
EP3721233A2 (en) 2017-12-09 2020-10-14 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
JP7379165B2 (ja) 2017-12-09 2023-11-14 アボット・ラボラトリーズ Ｇｆａｐとｕｃｈ－ｌ１との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法
US12601748B2 (en) * 2019-01-31 2026-04-14 Universite De Geneve Prospective markers in traumatic brain injury (TBI)
CA3189613A1 (en) 2020-08-17 2022-02-24 Raul DE MACEDO QUEIXADA Device and method for measuring the level of biomarkers and pathogens in substances
US20220244274A1 (en) * 2021-02-02 2022-08-04 University Of Iowa Research Foundation Quantitative biomarkers for assessing mild traumatic brain injury and methods of use thereof
US20220381796A1 (en) * 2021-05-18 2022-12-01 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
WO2022266034A1 (en) * 2021-06-14 2022-12-22 Abbott Laboratories Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
JP2024534849A (ja) * 2021-08-31 2024-09-26 アボット・ラボラトリーズ 脳の損傷を診断する方法及びシステム
JP2024538608A (ja) * 2021-09-30 2024-10-23 アボット・ラボラトリーズ 脳の損傷を診断する方法及びシステム
EP4220165A1 (en) * 2022-01-31 2023-08-02 HES-SO Valais-Wallis Method and device for the detection of traumatic brain injuries
CN120167040A (zh) 2022-06-29 2025-06-17 雅培实验室 用于确定生物样本中的gfap的磁性定点照护型系统和测定
WO2024211475A1 (en) * 2023-04-04 2024-10-10 Abbott Laboratories Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)

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