JP7267993B2 - ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物 - Google Patents

ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物 Download PDF

Info

Publication number
JP7267993B2
JP7267993B2 JP2020508394A JP2020508394A JP7267993B2 JP 7267993 B2 JP7267993 B2 JP 7267993B2 JP 2020508394 A JP2020508394 A JP 2020508394A JP 2020508394 A JP2020508394 A JP 2020508394A JP 7267993 B2 JP7267993 B2 JP 7267993B2
Authority
JP
Japan
Prior art keywords
alkyl
compound
optionally substituted
hydroxy
aspects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020508394A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020531423A (ja
JP2020531423A5 (enExample
Inventor
ジョァ・リ
ミン・ユ
チン・シュイ
マヌエル・ザンカネラ
Original Assignee
グローバル ブラッド セラピューティクス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グローバル ブラッド セラピューティクス インコーポレイテッド filed Critical グローバル ブラッド セラピューティクス インコーポレイテッド
Publication of JP2020531423A publication Critical patent/JP2020531423A/ja
Publication of JP2020531423A5 publication Critical patent/JP2020531423A5/ja
Application granted granted Critical
Publication of JP7267993B2 publication Critical patent/JP7267993B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020508394A 2017-08-15 2018-08-13 ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物 Active JP7267993B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762545936P 2017-08-15 2017-08-15
US62/545,936 2017-08-15
US201862712864P 2018-07-31 2018-07-31
US62/712,864 2018-07-31
PCT/US2018/046541 WO2019036377A1 (en) 2017-08-15 2018-08-13 TRICYCLIC COMPOUNDS AS HISTONE INHIBITORS METHYLTRANSFERASES

Publications (3)

Publication Number Publication Date
JP2020531423A JP2020531423A (ja) 2020-11-05
JP2020531423A5 JP2020531423A5 (enExample) 2021-09-30
JP7267993B2 true JP7267993B2 (ja) 2023-05-02

Family

ID=63452724

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020508394A Active JP7267993B2 (ja) 2017-08-15 2018-08-13 ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物

Country Status (13)

Country Link
US (1) US11661410B2 (enExample)
EP (1) EP3668863B1 (enExample)
JP (1) JP7267993B2 (enExample)
CN (1) CN111372927A (enExample)
BR (1) BR112020003073A2 (enExample)
ES (1) ES3016407T3 (enExample)
IL (1) IL272507A (enExample)
MX (1) MX2020001825A (enExample)
SA (1) SA520411303B1 (enExample)
SG (1) SG11202001090WA (enExample)
TW (1) TW201920136A (enExample)
WO (1) WO2019036377A1 (enExample)
ZA (1) ZA202001503B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3612181A4 (en) 2017-04-21 2021-01-06 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
WO2019036384A1 (en) 2017-08-15 2019-02-21 Global Blood Therapeutics, Inc. TRICYCLIC COMPOUNDS AS HISTONE INHIBITORS METHYLTRANSFERASES
CA3239101A1 (en) * 2021-11-25 2023-06-01 Gang Deng Tricyclic derivative and preparation method therefor and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US20170000784A1 (en) 2013-12-08 2017-01-05 Van Andel Research Institute Autophagy Inhibitors
US9284272B2 (en) * 2014-03-28 2016-03-15 Abbvie Inc. Inhibitors of histone methyltransferase G9a
US9840500B2 (en) 2014-06-16 2017-12-12 Fundación Para La Investigación Médica Aplicada Compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases
WO2017102677A1 (en) 2015-12-14 2017-06-22 Fundación Para La Investigación Médica Aplicada 2,4,6,7-tetrasubstituted quinoline compounds as inhibitors of dna methyltransferases
US11254651B2 (en) 2016-02-17 2022-02-22 Global Blood Therapeutics, Inc. Histone methyltransferase inhibitors
WO2019036384A1 (en) 2017-08-15 2019-02-21 Global Blood Therapeutics, Inc. TRICYCLIC COMPOUNDS AS HISTONE INHIBITORS METHYLTRANSFERASES

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Database REGISTRY，2016年，Retrieved from STN international [online] ;retrieved on 2 August 2022，RN 1990535-77-7 他
Del Giudice, Maria Rosaria et al，Synthesis and cholinesterase inhibitory activity of 6-, 7-methoxy-(and hydroxy-) tacrine derivatives，Farmaco，1996年，51(11),，693-698
Kshatriya, K. C. et al，Acridine derivatives as antimalarials. VI. 9-(Dialkyl-aminoalkyl)amino derivatives of 2,7-dimethoxy-3-chloro-, 2-methoxy-3-chloro-, and 2-methoxy-3,6-dichloroacridine，Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine，1950年，19;28，69-72，(Pt. 3 (Sci. No.))
Sanchez, Isabel et al，Synthesis and biological evaluation of modified acridines: the effect of N- and O- substituent in the nitrogenated ring on antitumor activity，European Journal of Medicinal Chemistry ，2006年，41(3),，340-352
Saracoglu, Murat et al，The investigation of structure-activity relationships of tacrine analogues: electronic-topological method，Open Medicinal Chemistry Journal ，2008年，2,，75-80
Tang, Jianhong et al，The divergent transformations of aromatic o-aminonitrile with carbonyl compound，Journal of Heterocyclic Chemistry，2012年，49(3),，533-542
Zhou, Jinpei et al，Synthesis and biological activities of tetrahydroacridine derivatives，Zhongguo Yaowu Huaxue Zazhi ，2000年，10(3),，172-176

Also Published As

Publication number Publication date
ZA202001503B (en) 2023-07-26
SA520411303B1 (ar) 2023-12-27
EP3668863A1 (en) 2020-06-24
EP3668863C0 (en) 2025-03-19
US20230002351A1 (en) 2023-01-05
WO2019036377A1 (en) 2019-02-21
MX2020001825A (es) 2020-03-20
EP3668863B1 (en) 2025-03-19
JP2020531423A (ja) 2020-11-05
TW201920136A (zh) 2019-06-01
IL272507A (en) 2020-03-31
ES3016407T3 (en) 2025-05-09
CN111372927A (zh) 2020-07-03
BR112020003073A2 (pt) 2020-08-25
US11661410B2 (en) 2023-05-30
SG11202001090WA (en) 2020-03-30

Similar Documents

Publication Publication Date Title
JP7755632B2 (ja) 統合的ストレス経路のモジュレーター
US11713299B2 (en) Histone methyltransferase inhibitors
JP2024045176A (ja) メニン－ｍｌｌ相互作用の阻害剤
JP6894914B2 (ja) ヒストンメチルトランスフェラーゼ阻害剤
JP7267993B2 (ja) ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物
JP7225125B2 (ja) ヒストンメチルトランスフェラーゼ阻害剤としてのアザインドール化合物
US11584734B2 (en) Tricyclic compounds as histone methyltransferase inhibitors
OA19495A (en) Tricyclic compounds as Histone Methyltransferase inhibitors.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210812

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210812

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220714

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220823

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221121

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230120

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230322

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230420

R150 Certificate of patent or registration of utility model

Ref document number: 7267993

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150