JP7261538B2 - 乳房上皮幹細胞を増殖させるための培養培地 - Google Patents
乳房上皮幹細胞を増殖させるための培養培地 Download PDFInfo
- Publication number
- JP7261538B2 JP7261538B2 JP2017528101A JP2017528101A JP7261538B2 JP 7261538 B2 JP7261538 B2 JP 7261538B2 JP 2017528101 A JP2017528101 A JP 2017528101A JP 2017528101 A JP2017528101 A JP 2017528101A JP 7261538 B2 JP7261538 B2 JP 7261538B2
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- cells
- organoids
- cell
- breast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0631—Mammary cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021179965A JP7602446B2 (ja) | 2014-11-27 | 2021-11-04 | 乳房上皮幹細胞を増殖させるための培養培地 |
| JP2024072368A JP2024102169A (ja) | 2014-11-27 | 2024-04-26 | 乳房上皮幹細胞を増殖させるための培養培地 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1421094.2A GB201421094D0 (en) | 2014-11-27 | 2014-11-27 | Culture medium |
| GB1421094.2 | 2014-11-27 | ||
| PCT/EP2015/077988 WO2016083612A1 (en) | 2014-11-27 | 2015-11-27 | Culture medium for expanding breast epithelial stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179965A Division JP7602446B2 (ja) | 2014-11-27 | 2021-11-04 | 乳房上皮幹細胞を増殖させるための培養培地 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536827A JP2017536827A (ja) | 2017-12-14 |
| JP7261538B2 true JP7261538B2 (ja) | 2023-04-20 |
Family
ID=52349562
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528101A Active JP7261538B2 (ja) | 2014-11-27 | 2015-11-27 | 乳房上皮幹細胞を増殖させるための培養培地 |
| JP2021179965A Active JP7602446B2 (ja) | 2014-11-27 | 2021-11-04 | 乳房上皮幹細胞を増殖させるための培養培地 |
| JP2024072368A Pending JP2024102169A (ja) | 2014-11-27 | 2024-04-26 | 乳房上皮幹細胞を増殖させるための培養培地 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179965A Active JP7602446B2 (ja) | 2014-11-27 | 2021-11-04 | 乳房上皮幹細胞を増殖させるための培養培地 |
| JP2024072368A Pending JP2024102169A (ja) | 2014-11-27 | 2024-04-26 | 乳房上皮幹細胞を増殖させるための培養培地 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10961511B2 (enExample) |
| EP (2) | EP3224351B1 (enExample) |
| JP (3) | JP7261538B2 (enExample) |
| AU (1) | AU2015352350B2 (enExample) |
| DK (1) | DK3224351T3 (enExample) |
| ES (1) | ES2883159T3 (enExample) |
| GB (1) | GB201421094D0 (enExample) |
| PT (1) | PT3224351T (enExample) |
| WO (1) | WO2016083612A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| EP3061808B1 (en) | 2009-02-03 | 2020-08-12 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| TR201815226T4 (tr) | 2011-12-19 | 2018-11-21 | Koninklijke Nederlandse Akademie Van Wetenschappen | Birincil intestinal kültür modelindeki cftr fonksiyonunu ölçmek için hızlı ve nicel bir analiz. |
| US10597633B2 (en) | 2014-05-16 | 2020-03-24 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for organoids |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| CN116790476A (zh) | 2016-05-05 | 2023-09-22 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| GB201611982D0 (en) | 2016-07-11 | 2016-08-24 | Cellesce Ltd | Cell culture |
| EP3523418A4 (en) * | 2016-10-06 | 2020-06-17 | Transgenex Nanobiotech, Inc. | METHOD FOR THE EXPANSION OF CANCER STEM CELLS (CSC) |
| KR102546194B1 (ko) | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| KR102558606B1 (ko) | 2016-12-05 | 2023-07-26 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3630949A4 (en) | 2017-05-29 | 2021-03-10 | Stemcell Technologies Canada Inc. | COMPOSITIONS AND PROCESSES FOR OBTAINING ORGANOIDS |
| WO2019006111A1 (en) * | 2017-06-28 | 2019-01-03 | Rutgers, The State University Of New Jersey | ORGANOIDS DERIVED FROM A SINGLE MAMMARY CELL |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| TWI703215B (zh) * | 2017-12-28 | 2020-09-01 | 財團法人生物技術開發中心 | 用於預測藥物功效之活體外診斷方法 |
| AU2019242912B2 (en) | 2018-03-28 | 2025-07-17 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| WO2019199881A1 (en) * | 2018-04-09 | 2019-10-17 | Cedars-Sinai Medical Center | Methods for in vitro expansion of adult tissue stem cells |
| JP7506657B2 (ja) | 2018-07-26 | 2024-06-26 | チルドレンズ ホスピタル メディカル センター | 肝胆膵組織およびその作製方法 |
| US12428622B2 (en) | 2018-09-12 | 2025-09-30 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| BR112021006067A2 (pt) * | 2018-09-27 | 2021-07-20 | The Regents Of The University Of California | métodos de isolação e cultura de célula progenitora retinal humana |
| CA3116711A1 (en) * | 2018-10-16 | 2020-04-23 | Board Of Regents,The University Of Texas System | Compositions for and methods of producing tumor organoids |
| GB201819224D0 (en) | 2018-11-26 | 2019-01-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Hepatocyte expansion methods |
| GB201903573D0 (en) | 2019-03-15 | 2019-05-01 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for head and neck organoids |
| GB201906978D0 (en) | 2019-05-17 | 2019-07-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method using integrin agonist |
| JP7610533B2 (ja) | 2019-05-31 | 2025-01-08 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞の生成および拡大方法 |
| BR112022005225A2 (pt) * | 2019-09-19 | 2022-08-16 | Univ Northwestern | Meio de cultura econômico e protocolo para células-tronco pluripotentes induzidas humanas |
| JP2022551869A (ja) * | 2019-10-10 | 2022-12-14 | ユニバーシティー オブ ヒューストン システム | 重層上皮幹細胞のためのフィーダーベースおよびフィーダーフリーの幹細胞培養系ならびにそれらに関連した使用方法 |
| WO2021081253A1 (en) | 2019-10-22 | 2021-04-29 | Tempus Labs, Inc. | Systems and methods for predicting therapeutic sensitivity |
| CN112779209B (zh) * | 2019-11-08 | 2023-01-24 | 合肥中科普瑞昇生物医药科技有限公司 | 原代乳腺上皮细胞培养基、培养方法及其应用 |
| US11629385B2 (en) | 2019-11-22 | 2023-04-18 | Tempus Labs, Inc. | Tumor organoid culture compositions, systems, and methods |
| EP4070098B1 (en) | 2019-12-05 | 2025-12-24 | Tempus AI, Inc. | Large scale organoid analysis |
| CN111424015A (zh) * | 2019-12-10 | 2020-07-17 | 重庆康克唯生物科技有限公司 | 用于前列腺肿瘤细胞的培养基和三维培养方法 |
| CN113528425B (zh) * | 2020-04-15 | 2023-05-30 | 合肥中科普瑞昇生物医药科技有限公司 | 一种用于乳腺上皮肿瘤细胞的培养基和培养方法 |
| US11561178B2 (en) | 2020-04-20 | 2023-01-24 | Tempus Labs, Inc. | Artificial fluorescent image systems and methods |
| NL2027546B1 (en) * | 2021-02-11 | 2022-09-12 | Prinses Maxima Centrum Voor Kinderoncologie B V | Method of producing an organoid |
| CA3215516A1 (en) * | 2021-04-16 | 2022-10-20 | David ROWBOTHAM | Media and methods for growing mammary organoids |
| TWI794821B (zh) * | 2021-05-20 | 2023-03-01 | 國立陽明交通大學 | 用於在體外培養原代人類肺泡上皮細胞的方法 |
| CN117821380A (zh) * | 2021-07-05 | 2024-04-05 | 浙江大学 | Fgf7在制备促进干细胞体外扩增和维持表型的试剂中的应用 |
| CN114317442B (zh) * | 2022-01-07 | 2025-02-07 | 重庆嘉士腾医药有限公司 | 一种建立乳腺类器官或/和乳腺癌类器官的培养基及方法和应用 |
| WO2023137465A1 (en) * | 2022-01-13 | 2023-07-20 | BIOMILQ, Inc. | Optimization of live cell constructs for production of cultured milk product and methods of using the same |
| CN114591887B (zh) * | 2022-03-14 | 2022-10-14 | 杭州艾名医学科技有限公司 | 一种乳腺癌类器官培养液及制备方法和培养方法 |
| GB202204266D0 (en) | 2022-03-25 | 2022-05-11 | Stichting Hubrecht Organoid Tech | Methods for co-culturing genotoxic bacteria and organoids |
| EP4495227A1 (en) | 2023-07-18 | 2025-01-22 | HUB Organoids IP B.V. | Co-cultures of organoids and stromal cells |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012525148A (ja) | 2009-04-27 | 2012-10-22 | バイアサイト インク | 低分子サポート多能性細胞成育およびその方法 |
| WO2014066649A1 (en) | 2012-10-26 | 2014-05-01 | The Regents Of The University Of California | A strategy for engineering various 3d tissues, organoids and vasculature |
| JP2014516562A (ja) | 2011-06-10 | 2014-07-17 | コーニンクレッカ ネザーランド アカデミー ヴァン ウェテンシャッペン | 幹細胞のための培養培地 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09512910A (ja) | 1994-05-04 | 1997-12-22 | マウント・サイナイ・ホスピタル・コーポレイション | TGF−βスーパーファミリーのサイトカインの変調因子およびそのアッセイ方法 |
| EP0953633A1 (en) | 1998-04-28 | 1999-11-03 | Livercell L.L.C. | Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells |
| WO2000050049A2 (en) | 1999-02-24 | 2000-08-31 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Artificial salivary gland |
| US20030003088A1 (en) | 2001-05-03 | 2003-01-02 | Board Of Trustees Operating Michigan State University | Human pancreatic pluripotential stem cell line |
| AU2002367580A1 (en) | 2001-05-16 | 2003-09-22 | Tracy C. Grikscheit | Tissue-engineered organs |
| AU2002331669A1 (en) | 2001-08-23 | 2003-03-10 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
| CA2463914A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| WO2004050827A2 (en) | 2002-12-05 | 2004-06-17 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
| WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
| US20040229355A1 (en) | 2003-05-14 | 2004-11-18 | Board Of Regents University Of Texas System | Culture medium for long-term culture of hepatocytes |
| US20070010008A1 (en) | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
| WO2005040391A1 (en) | 2003-10-27 | 2005-05-06 | Murdoch Childrens Research Institute | Compositions and methods for differentiating stem cells |
| US20070036769A9 (en) | 2004-06-03 | 2007-02-15 | Linheng Li | BMP pathway methods and compositions |
| GB0413005D0 (en) | 2004-06-11 | 2004-07-14 | Coletica | Ligand |
| US8492148B2 (en) | 2005-02-23 | 2013-07-23 | Foundation For Biomedical Research & Innovation | Method for amplification of endothelial progenitor cell in vitro |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| WO2007030693A2 (en) | 2005-09-08 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| DK2420565T3 (en) | 2006-02-23 | 2017-12-04 | Viacyte Inc | APPLICABLE COMPOSITIONS AND METHODS FOR CULTIVATING DIFFERENTIBLE CELLS |
| US7989204B2 (en) | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
| US8628964B2 (en) | 2006-10-11 | 2014-01-14 | Drexel University | Fetal pulmonary cells and uses thereof |
| CA2664828A1 (en) | 2006-10-20 | 2008-04-24 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| US9251637B2 (en) | 2006-11-15 | 2016-02-02 | Bank Of America Corporation | Method and apparatus for using at least a portion of a one-time password as a dynamic card verification value |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| US20080233088A1 (en) | 2007-02-16 | 2008-09-25 | Varian Medical Systems Technologies, Inc. | Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation |
| EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
| JP2009195142A (ja) | 2008-02-20 | 2009-09-03 | Institute Of Physical & Chemical Research | 肝臓卵形細胞の取得方法 |
| CA2723648A1 (en) * | 2008-04-10 | 2009-10-15 | Piyush Gupta | Methods for identification and use of agents targeting cancer stem cells |
| WO2010011352A2 (en) * | 2008-07-25 | 2010-01-28 | The University Of Georgia Research Foundation, Inc. | Compositions for mesoderm derived isl1+ multipotent cells (imps), epicardial progenitor cells (epcs) and multipotent cxcr4+cd56+ cells (c56cs) and methods of use |
| WO2010016766A2 (en) | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| US9464275B2 (en) | 2008-08-21 | 2016-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Ex vivo culture, proliferation and expansion of intestinal epithelium |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP3061808B1 (en) | 2009-02-03 | 2020-08-12 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| EP2580320B1 (en) | 2010-06-14 | 2018-08-01 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| SG188666A1 (en) | 2010-09-30 | 2013-05-31 | Agency Science Tech & Res | Methods and reagents for detection and treatment of esophageal metaplasia |
| KR102482184B1 (ko) | 2010-12-22 | 2022-12-28 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| CA2839102A1 (en) | 2011-06-29 | 2013-01-03 | The Penn State Research Foundation | Compositions, methods and kits for treating leukemia |
| US20130052729A1 (en) | 2011-08-29 | 2013-02-28 | Olivier Pourquie | Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use |
| US9663573B2 (en) | 2011-10-05 | 2017-05-30 | Genentech, Inc. | Methods of treating liver conditions using Notch2 antagonists |
| GB201117469D0 (en) | 2011-10-10 | 2011-11-23 | Cell Guidance Systems Ltd | Culture media for pluripotent stem cells |
| JP6238445B2 (ja) | 2011-10-27 | 2017-11-29 | 国立大学法人 東京医科歯科大学 | 大腸上皮幹細胞の単離・培養技術と、これを用いた大腸上皮移植技術 |
| US20140302491A1 (en) | 2011-10-28 | 2014-10-09 | The Board Of Trustees Of The Leland Stanford Junior University | Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids |
| TR201815226T4 (tr) | 2011-12-19 | 2018-11-21 | Koninklijke Nederlandse Akademie Van Wetenschappen | Birincil intestinal kültür modelindeki cftr fonksiyonunu ölçmek için hızlı ve nicel bir analiz. |
| WO2014127170A1 (en) | 2013-02-13 | 2014-08-21 | Wake Forest University Health Sciences | Bioengineered liver constructs and methods relating thereto |
| WO2014127219A1 (en) | 2013-02-14 | 2014-08-21 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| AU2014218290B2 (en) | 2013-02-18 | 2020-03-12 | The Hospital For Sick Children | Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells |
| CA2905842C (en) | 2013-03-14 | 2023-02-21 | The Brigham And Women's Hospital, Inc. | Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor |
| PT3929207T (pt) | 2013-03-15 | 2024-10-21 | Univ Texas | Utilização do péptido fttftvt no tratamento de fibrose |
| CA3205855A1 (en) | 2013-04-16 | 2014-10-23 | Orbsen Therapeutics Limited | Medical use of syndecan-2 |
| US10597633B2 (en) | 2014-05-16 | 2020-03-24 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for organoids |
| US11920164B2 (en) | 2014-07-30 | 2024-03-05 | Yeda Research And Development Co. Ltd. | Media for culturing naive human pluripotent stem cells |
| EP3204489A4 (en) | 2014-10-08 | 2018-09-05 | Agency for Science, Technology and Research | Methods of differentiating stem cells into liver cell lineages |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| GB201610748D0 (en) | 2016-06-20 | 2016-08-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved diffrentation method |
-
2014
- 2014-11-27 GB GBGB1421094.2A patent/GB201421094D0/en not_active Ceased
-
2015
- 2015-11-27 ES ES15801830T patent/ES2883159T3/es active Active
- 2015-11-27 PT PT158018309T patent/PT3224351T/pt unknown
- 2015-11-27 WO PCT/EP2015/077988 patent/WO2016083612A1/en not_active Ceased
- 2015-11-27 EP EP15801830.9A patent/EP3224351B1/en active Active
- 2015-11-27 JP JP2017528101A patent/JP7261538B2/ja active Active
- 2015-11-27 DK DK15801830.9T patent/DK3224351T3/da active
- 2015-11-27 US US15/529,150 patent/US10961511B2/en active Active
- 2015-11-27 AU AU2015352350A patent/AU2015352350B2/en active Active
- 2015-11-27 EP EP21182510.4A patent/EP3950937A1/en active Pending
-
2021
- 2021-02-23 US US17/182,457 patent/US20210254017A1/en not_active Abandoned
- 2021-11-04 JP JP2021179965A patent/JP7602446B2/ja active Active
-
2024
- 2024-04-26 JP JP2024072368A patent/JP2024102169A/ja active Pending
- 2024-06-25 US US18/753,207 patent/US20250154472A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012525148A (ja) | 2009-04-27 | 2012-10-22 | バイアサイト インク | 低分子サポート多能性細胞成育およびその方法 |
| JP2014516562A (ja) | 2011-06-10 | 2014-07-17 | コーニンクレッカ ネザーランド アカデミー ヴァン ウェテンシャッペン | 幹細胞のための培養培地 |
| WO2014066649A1 (en) | 2012-10-26 | 2014-05-01 | The Regents Of The University Of California | A strategy for engineering various 3d tissues, organoids and vasculature |
Non-Patent Citations (1)
| Title |
|---|
| Pasic et al.,Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue,GENES & DEVELOPMENT,2011年,Vol.25, p.1641-1653 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2883159T3 (es) | 2021-12-07 |
| EP3224351B1 (en) | 2021-06-30 |
| PT3224351T (pt) | 2021-09-03 |
| US20170342385A1 (en) | 2017-11-30 |
| NZ732345A (en) | 2024-12-20 |
| EP3224351A1 (en) | 2017-10-04 |
| EP3950937A1 (en) | 2022-02-09 |
| JP2017536827A (ja) | 2017-12-14 |
| JP2022025124A (ja) | 2022-02-09 |
| JP2024102169A (ja) | 2024-07-30 |
| AU2015352350B2 (en) | 2021-07-29 |
| HK1245324A1 (zh) | 2018-08-24 |
| US20250154472A1 (en) | 2025-05-15 |
| JP7602446B2 (ja) | 2024-12-18 |
| US20210254017A1 (en) | 2021-08-19 |
| CA2968751A1 (en) | 2016-06-02 |
| US10961511B2 (en) | 2021-03-30 |
| AU2015352350A1 (en) | 2017-06-15 |
| DK3224351T3 (da) | 2021-08-23 |
| GB201421094D0 (en) | 2015-01-14 |
| WO2016083612A1 (en) | 2016-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7602446B2 (ja) | 乳房上皮幹細胞を増殖させるための培養培地 | |
| JP7319027B2 (ja) | 培養培地 | |
| US12331314B2 (en) | Culture method for organoids | |
| AU2020200515B2 (en) | Culture media for stem cells | |
| HK40069127A (en) | Culture medium for expanding breast epithelial stem cells | |
| CA2968751C (en) | Culture medium for expanding breast epithelial stem cells | |
| HK1245324B (en) | Culture medium for expanding breast epithelial stem cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180117 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20181126 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190925 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191007 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191227 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200706 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201001 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210104 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20210127 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210705 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20211104 |
|
| C116 | Written invitation by the chief administrative judge to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C116 Effective date: 20211117 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20211117 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211213 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20221031 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20221124 |
|
| C13 | Notice of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: C13 Effective date: 20221212 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230131 |
|
| C23 | Notice of termination of proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C23 Effective date: 20230213 |
|
| C03 | Trial/appeal decision taken |
Free format text: JAPANESE INTERMEDIATE CODE: C03 Effective date: 20230313 |
|
| C30A | Notification sent |
Free format text: JAPANESE INTERMEDIATE CODE: C3012 Effective date: 20230313 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230410 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7261538 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |