JP7254719B2 - 薬物送達用のポリマーペースト組成物 - Google Patents

薬物送達用のポリマーペースト組成物 Download PDF

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JP7254719B2
JP7254719B2 JP2019566745A JP2019566745A JP7254719B2 JP 7254719 B2 JP7254719 B2 JP 7254719B2 JP 2019566745 A JP2019566745 A JP 2019566745A JP 2019566745 A JP2019566745 A JP 2019566745A JP 7254719 B2 JP7254719 B2 JP 7254719B2
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paste
plga
molecular weight
daltons
drug
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JP2020523303A (ja
JP2020523303A5 (cg-RX-API-DMAC7.html
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ケー． ジャクソン，ジョン
イー． グリーブ，マーチン
シュミット，ヴェロニカ
ケッシュ，クラウディア
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ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019566745A 2017-06-13 2018-06-13 薬物送達用のポリマーペースト組成物 Active JP7254719B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762518800P 2017-06-13 2017-06-13
US62/518,800 2017-06-13
PCT/CA2018/050714 WO2018227293A1 (en) 2017-06-13 2018-06-13 Polymeric paste compositions for drug delivery

Publications (3)

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JP2020523303A JP2020523303A (ja) 2020-08-06
JP2020523303A5 JP2020523303A5 (cg-RX-API-DMAC7.html) 2021-07-26
JP7254719B2 true JP7254719B2 (ja) 2023-04-10

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JP2019566745A Active JP7254719B2 (ja) 2017-06-13 2018-06-13 薬物送達用のポリマーペースト組成物

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US (2) US11167034B2 (cg-RX-API-DMAC7.html)
EP (1) EP3638311A4 (cg-RX-API-DMAC7.html)
JP (1) JP7254719B2 (cg-RX-API-DMAC7.html)
CN (1) CN110740752B (cg-RX-API-DMAC7.html)
AU (1) AU2018285975B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019026225A2 (cg-RX-API-DMAC7.html)
CA (1) CA3067269C (cg-RX-API-DMAC7.html)
WO (1) WO2018227293A1 (cg-RX-API-DMAC7.html)

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GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US20200155449A1 (en) 2015-11-16 2020-05-21 Medincell Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
AU2018285975B2 (en) * 2017-06-13 2023-11-16 The University Of British Columbia Polymeric paste compositions for drug delivery
WO2019071245A1 (en) 2017-10-06 2019-04-11 Foundry Therapeutics, Inc. IMPLANTABLE DEPOSITS FOR REGULATED RELEASE OF ANALGESICS TO TREAT POSTHOPERATIVE PAIN ASSOCIATED WITH ORTHOPEDIC SURGERY, AND RELATED DEVICES, SYSTEMS, AND METHODS
CN116650732A (zh) 2018-01-08 2023-08-29 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
US12458589B2 (en) 2018-05-12 2025-11-04 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
WO2020047013A1 (en) 2018-08-28 2020-03-05 Foundry Therapeutics, Inc. Polymer implants
CN119950395A (zh) * 2019-04-11 2025-05-09 铸造疗法股份有限公司 用于治疗癌症和相关症状和病症的治疗剂的局部、持续、受控释放的可植入贮存库
CA3167259A1 (en) * 2020-02-07 2021-08-12 Veronika SCHMITT Mucoadhesive polymeric drug delivery compositions and methods
WO2024168423A1 (en) * 2023-02-14 2024-08-22 1376683 B.C. Ltd Topical copolymer formulations for hydrophobic drug delivery
WO2025058571A1 (en) * 2023-09-15 2025-03-20 Agency For Science, Technology And Research Polymer composition comprising a thermogelling polymer and a tyrosine kinase inhibitor, and related methods thereof

Citations (6)

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JP2003517886A (ja) 1999-12-22 2003-06-03 サムヤン コーポレイション ドラッグデリバリーシステム用生分解性ブロック共重合体の液体組成物およびその製造方法
JP2005535638A (ja) 2002-06-28 2005-11-24 マクロメド・インコーポレーテッド 薬剤送達のための生物分解性ブロックコポリマー組成物
JP2007524628A (ja) 2003-06-26 2007-08-30 シヴィダ・インコーポレイテッド Ｉｎ−Ｓｉｔｕゲル化薬物輸送システム
JP2008501455A (ja) 2004-06-09 2008-01-24 シル テクノロジー ゲーエムベーハー インサイチュー硬化ペースト、その製造および使用
JP2011530568A (ja) 2008-08-12 2011-12-22 ノバルティス アーゲー 医薬組成物
JP2012529922A (ja) 2009-06-15 2012-11-29 アボット カーディオヴァスキュラー システムズ インコーポレイテッド ポリ（エチレングリコール）及びポリ（ラクチド−グリコリド）のブロックコポリマーを含む埋込型医療機器及びそのためのコーティング物

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Publication number Priority date Publication date Assignee Title
JP2003517886A (ja) 1999-12-22 2003-06-03 サムヤン コーポレイション ドラッグデリバリーシステム用生分解性ブロック共重合体の液体組成物およびその製造方法
JP2005535638A (ja) 2002-06-28 2005-11-24 マクロメド・インコーポレーテッド 薬剤送達のための生物分解性ブロックコポリマー組成物
JP2007524628A (ja) 2003-06-26 2007-08-30 シヴィダ・インコーポレイテッド Ｉｎ−Ｓｉｔｕゲル化薬物輸送システム
JP2008501455A (ja) 2004-06-09 2008-01-24 シル テクノロジー ゲーエムベーハー インサイチュー硬化ペースト、その製造および使用
JP2011530568A (ja) 2008-08-12 2011-12-22 ノバルティス アーゲー 医薬組成物
JP2012529922A (ja) 2009-06-15 2012-11-29 アボット カーディオヴァスキュラー システムズ インコーポレイテッド ポリ（エチレングリコール）及びポリ（ラクチド−グリコリド）のブロックコポリマーを含む埋込型医療機器及びそのためのコーティング物

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CN110740752A (zh) 2020-01-31
JP2020523303A (ja) 2020-08-06
US11167034B2 (en) 2021-11-09
CN110740752B (zh) 2023-11-17
WO2018227293A1 (en) 2018-12-20
AU2018285975B2 (en) 2023-11-16
CA3067269A1 (en) 2018-12-20
CA3067269C (en) 2024-01-09
US20200147223A1 (en) 2020-05-14
BR112019026225A2 (pt) 2020-06-30
EP3638311A1 (en) 2020-04-22
US20220152207A1 (en) 2022-05-19
EP3638311A4 (en) 2020-12-16
AU2018285975A1 (en) 2020-01-02

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